Search Results - "FOX, Donald A"

Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice by He, Lihua, Perkins, Guy A, Poblenz, Ann T, Harris, Jeffrey B, Hung, Michael, Ellisman, Mark H, Fox, Donald A

“…Photoreceptor apoptosis and resultant visual deficits occur in humans and animals with inherited and disease-, injury-, and chemical-induced retinal…”
Get full text

The effect of physiologic aqueous solutions on the perovskite material lead-lanthanum-zirconium titanate (PLZT): potential retinotoxicity by Foster, William J., Meen, James K., Fox, Donald A.

“…Context: Perovskite compounds, including lead-lanthanum-zirconium titanate (PLZT), have wide technological application because of their unique physical…”
Get full text

Multiomics analyses reveal early metabolic imbalance and mitochondrial stress in neonatal photoreceptors leading to cell death in Pde6brd1/rd1 mouse model of retinal degeneration by Jiang, Ke, Mondal, Anupam Kumar, Adlakha, Yogita K, Gumerson, Jessica, Aponte, Angel, Gieser, Linn, Kim, Jung-Woong, Boleda, Alexis, Brooks, Matthew J, Nellissery, Jacob, Fox, Donald A, Balaban, Robert, Covian, Raul, Swaroop, Anand

“…Abstract Retinal diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. Mutations in over 200 genes can lead to…”
Get full text

The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases by Rueda, Elda M, Johnson, Jr, Jerry E, Giddabasappa, Anand, Swaroop, Anand, Brooks, Matthew J, Sigel, Irena, Chaney, Shawnta Y, Fox, Donald A

“…The homeostatic regulation of cellular ATP is achieved by the coordinated activity of ATP utilization, synthesis, and buffering. Glucose is the major substrate…”
Get full text

Gestational lead exposure in humans and experimental animals: Novel functional and morphological phenotype and late-onset retinal degeneration by Fox, Donald A

Get full text

Developmental origins of adult diseases and neurotoxicity: Epidemiological and experimental studies by Fox, Donald A., Grandjean, Philippe, de Groot, Didima, Paule, Merle G.

“…To date, only a small number of commercial chemicals have been tested and documented as developmental neurotoxicants. Moreover, an increasing number of…”
Get full text

Retinal and visual system: occupational and environmental toxicology by Fox, Donald A

“…Occupational chemical exposure often results in sensory systems alterations that occur without other clinical signs or symptoms. Approximately 3000 chemicals…”
Get more information

Photoreceptor Mitochondrial Reserve Capacity: Is It the Etiology for Differential Compartmental Vulnerability? by Fox, Donald A, Rueda, Elda M

Get full text

The History, Status, Gaps, and Future Directions of Neurotoxicology in China by Cai, Tongjian, Luo, Wenjing, Ruan, Diyun, Wu, Yi-Jun, Fox, Donald A, Chen, Jingyuan

“…Rapid economic development in China has produced serious ecological, environmental, and health problems. Neurotoxicity has been recognized as a major public…”
Get full text

Low-Level Human Equivalent Gestational Lead Exposure Produces Sex-Specific Motor and Coordination Abnormalities and Late-Onset Obesity in Year-Old Mice by Leasure, J. Leigh, Giddabasappa, Anand, Chaney, Shawntay, Johnson, Jerry E., Pothakos, Konstantinos, Lau, Yuen Sum, Fox, Donald A.

“…Background: Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational…”
Get full text

RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina by Poché, Ross A., Zhang, Min, Rueda, Elda M., Tong, Xuefei, McElwee, Melissa L., Wong, Leeyean, Hsu, Chih-Wei, Dejosez, Marion, Burns, Alan R., Fox, Donald A., Martin, James F., Zwaka, Thomas P., Dickinson, Mary E.

“…A fundamental principle governing organ size and function is the fine balance between cell proliferation and cell differentiation. Here, we identify RONIN…”
Get full text

Adult lead exposure increases blood-retinal permeability: A risk factor for retinal vascular disease by Shen, Xue-Feng, Huang, Ping, Fox, Donald A., Lin, Yan, Zhao, Zai-Hua, Wang, Wen, Wang, Ji-Ye, Liu, Xin-Qin, Chen, Jing-Yuan, Luo, Wen-Jing

“…•Lead exposure presents dose-dependent alternations in retina structure and BRB permeability.•Occludin and claudin-5 mediates the increased BRB…”
Get full text

Increased proliferation of late-born retinal progenitor cells by gestational lead exposure delays rod and bipolar cell differentiation by Chaney, Shawnta Y, Mukherjee, Shradha, Giddabasappa, Anand, Rueda, Elda M, Hamilton, W Ryan, Johnson, Jr, Jerry E, Fox, Donald A

“…Studies of neuronal development in the retina often examine the stages of proliferation, differentiation, and synaptic development, albeit independently. Our…”
Get full text

Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption by Perkins, Guy A, Scott, Ray, Perez, Alex, Ellisman, Mark H, Johnson, Jerry E, Fox, Donald A

“…Postnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision…”
Get full text

Low-Level Gestational Lead Exposure Increases Retinal Progenitor Cell Proliferation and Rod Photoreceptor and Bipolar Cell Neurogenesis in Mice by Giddabasappa, Anand, Hamilton, W. Ryan, Chaney, Shawntay, Xiao, Weimin, Johnson, Jerry E., Mukherjee, Shradha, Fox, Donald A.

“…Background: Gestational lead exposure (GLE) produces novel and persistent rod-mediated electroretinographic (ERG) supernormality in children and adult animals…”
Get full text

Gene–chemical interactions in the developing mammalian nervous system: Effects on proliferation, neurogenesis and differentiation by Fox, Donald A., Opanashuk, Lisa, Zharkovsky, Aleksander, Weiss, Bernie

“…The orderly formation of the nervous system requires a multitude of complex, integrated and simultaneously occurring processes. Neural progenitor cells expand…”
Get full text

Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses by Johnson, Jr, Jerry E, Perkins, Guy A, Giddabasappa, Anand, Chaney, Shawntay, Xiao, Weimin, White, Andrew D, Brown, Joshua M, Waggoner, Jenna, Ellisman, Mark H, Fox, Donald A

“…In conventional neurons, Ca2+ enters presynaptic terminals during an action potential and its increased local concentration triggers transient exocytosis. In…”
Get full text

Dynamics of the Rhomboid-like Protein RHBDD2 Expression in Mouse Retina and Involvement of Its Human Ortholog in Retinitis Pigmentosa by Ahmedli, Novruz B., Gribanova, Yekaterina, Njoku, Collins C., Naidu, Akash, Young, Alejandra, Mendoza, Emmanuel, Yamashita, Clyde K., Özgül, Riza Köksal, Johnson, Jerry E., Fox, Donald A., Farber, Debora B.

“…The novel rhomboid-like protein RHBDD2 is distantly related to rhomboid proteins, a group of highly specialized membrane-bound proteases that catalyze…”
Get full text

Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice by Fox, Donald A., Hamilton, W. Ryan, Johnson, Jerry E., Xiao, Weimin, Chaney, Shawntay, Mukherjee, Shradha, Miller, Diane B., O'Callaghan, James P.

“…Gestational lead exposure (GLE) produces supernormal scotopic electroretinograms (ERG) in children, monkeys and rats, and a novel retinal phenotype…”
Get full text

Neurodevelopmental basis of health and disease: The 14th meeting of the International Neurotoxicology Association by Llorens, Jordi, van Thriel, Christoph, Fox, Donald A., Lammers, Jan, Westerink, Remco H.S., de Groot, Didima M.G.

Get full text