Search Results - "FOWLER, C. J"

The endocannabinoid system – current implications for drug development by Fowler, C. J.

“…In this review, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a focus on the treatment of pain. Amongst…”
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Monoacylglycerol lipase – a target for drug development? by Fowler, CJ

“…The endocannabinoid (eCB) system is involved in processes as diverse as control of appetite, perception of pain and the limitation of cancer cell growth and…”
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Second consensus statement on the diagnosis of multiple system atrophy by GILMAN, S, WENNING, G. K, KAUFMANN, H, KLOCKGETHER, T, LEES, A, POEWE, W, QUINN, N, REVESZ, T, ROBERTSON, D, SANDRONI, P, SEPPI, K, VIDAILHET, M, LOW, P. A, BROOKS, D. J, MATHIAS, C. J, TROJANOWSKI, J. Q, WOOD, N. W, COLOSIMO, C, DÜRR, A, FOWLER, C. J

“…A consensus conference on multiple system atrophy (MSA) in 1998 established criteria for diagnosis that have been accepted widely. Since then, clinical,…”
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The micturition switch and its forebrain influences by Griffiths, D. J., Fowler, C. J.

“…Dr DeGroat and Wickens has reviewed the central neural mechanisms controlling the lower urinary tract with a major focus on the brain stem circuitry that…”
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The contribution of cyclooxygenase‐2 to endocannabinoid metabolism and action by Fowler, C J

“…The development of sensitive analytical methods for measurement of endocannabinoids, their metabolites, and related lipids, has underlined the complexity of…”
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Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis by Kavia, RBC, De Ridder, D, Constantinescu, CS, Stott, CG, Fowler, CJ

“…Background: Bladder dysfunction is a common feature of multiple sclerosis (MS). Objective: In this study we aimed to assess the efficacy, tolerability and…”
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Insula and amygdala resting‐state functional connectivity differentiate bipolar from unipolar depression by Ambrosi, E., Arciniegas, D. B., Madan, A., Curtis, K. N., Patriquin, M. A., Jorge, R. E., Spalletta, G., Fowler, J. C., Frueh, B. C., Salas, R.

“…Objective Distinguishing depressive episodes due to bipolar disorder (BD) or major depressive disorder (MDD) solely on clinical grounds is challenging. We…”
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A UK consensus on the management of the bladder in multiple sclerosis by Fowler, C J, Panicker, J N, Drake, M, Harris, C, Harrison, S C W, Kirby, M, Lucas, M, Macleod, N, Mangnall, J, North, A, Porter, B, Reid, S, Russell, N, Watkiss, K, Wells, M

“…Bladder symptoms in multiple sclerosis (MS) are common and distressing but also highly amenable to treatment. A meeting of stakeholders involved in patients’…”
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The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1 by Fowler, CJ, Naidu, PS, Lichtman, A, Onnis, V

“…Mandarin translation of Although the dominant approach to drug development is the design of compounds selective for a given target, compounds targeting more…”
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Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids by Thors, L, Belghiti, M, Fowler, C J

“…Background and purpose: Recent studies have demonstrated that the naturally occurring isoflavone compounds genistein and daidzein inhibit the hydrolysis of…”
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Lack of selectivity of URB602 for 2‐oleoylglycerol compared to anandamide hydrolysis in vitro by Vandevoorde, S, Jonsson, K‐O, Labar, G, Persson, E, Lambert, D M, Fowler, C J

“…Background and purpose: Two compounds, URB602 and URB754, have been reported in the literature to be selective inhibitors of monoacylglycerol lipase, although…”
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Inhibition of monoacylglycerol lipase by troglitazone, N‐arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays by Björklund, E, Norén, E, Nilsson, J, Fowler, CJ

“…BACKGROUND AND PURPOSE Drugs used clinically usually have a primary mechanism of action, but additional effects on other biological targets can contribute to…”
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Brain responses to changes in bladder volume and urge to void in healthy men by Athwal, B. S., Berkley, K. J., Hussain, I., Brennan, A., Craggs, M., Sakakibara, R., Frackowiak, R. S. J., Fowler, C. J.

“…Knowledge of how changes in bladder volume and the urge to void affect brain activity is important for understanding brain mechanisms that control urinary…”
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An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis by Brady, C M, DasGupta, R, Dalton, C, Wiseman, O J, Berkley, K J, Fowler, C J

“…The majority of patients with multiple sclerosis (MS) develop troublesome lower urinary tract symptoms (LUTS). Anecdotal reports suggest that cannabis may…”
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EAU Guidelines on Chronic Pelvic Pain by Fall, M., Baranowski, A.P., Fowler, C.J., Lepinard, V., Malone-Lee, J.G., Messelink, E.J., Oberpenning, F., Osborne, J.L., Schumacher, S.

“…On behalf of the European Association of Urology (EAU) guidelines for diagnosis, therapy and follow-up of chronic pelvic pain patients were established…”
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The role of the human bladder lamina propria myofibroblast by Wiseman, O.J., Fowler, C.J., Landon, D.N.

“…OBJECTIVES To describe the ultrastructure and relationship to nerves of the myofibroblast in the human bladder lamina propria, and discuss its possible role in…”
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Rescue from failed growth factor and or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience by Fowler, C J, Dunn, A, Hayes-Lattin, B, Hansen, K, Hansen, L, Lanier, K, Nelson, V, Kovacsovics, T, Leis, J, Calandra, G, Maziarz, R T

“…Auto-SCT has been shown to be a potentially curative treatment for a variety of hematological malignancies. Auto-SCT is dependent on the successful…”
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Interaction of ligands for the peroxisome proliferator‐activated receptor γ with the endocannabinoid system by Lenman, A, Fowler, C J

“…Background and purpose: There is good evidence that agents interacting with the endocannabinoid system in the body can also interact with the peroxisome…”
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Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine by Szabo, Steven T., Fowler, J.C., Froeliger, Brett, Lee, Tong H.

“…•Changes in nicotinic neurotransmission may play a role in cocaine behavioral sensitization.•Locomotor stimulation by nicotine increases during early cocaine…”
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Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension by Hussain, I F, Brady, C M, Swinn, M J, Mathias, C J, Fowler, C J

“…OBJECTIVES To assess the efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and parkinsonism due either to Parkinson's disease…”
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