Search Results - "FOUNTAIN, Scott"

Fit-for-purpose method development and validation for successful biomarker measurement by LEE, Jean W, DEVANARAYAN, Viswanath, ROGERS, James A, MILLHAM, Robert, O'BRIEN, Peter J, SAILSTAD, Jeff, KHAN, Masood, RAY, Chad, WAGNER, John A, BARRETT, Yu Chen, WEINER, Russell, ALLINSON, John, FOUNTAIN, Scott, KELLER, Stephen, WEINRYB, Ira, GREEN, Marie, DUAN, Larry

“…Despite major advances in modern drug discovery and development, the number of new drug approvals has not kept pace with the increased cost of their…”
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The 'blended' bioanalytical laboratory: the marriage of antibody- and instrument-based methods and expertise by Fountain, Scott T

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Clinical validation of an immunoaffinity LC–MS/MS assay for the quantification of a collagen type II neoepitope peptide: A biomarker of matrix metalloproteinase activity and osteoarthritis in human urine by Li, Wenlin (Wendy), Nemirovskiy, Olga, Fountain, Scott, Rodney Mathews, W., Szekely-Klepser, Gabriella

“…The degradation of type II collagen has been associated with the pathology of osteoarthritis (OA). Matrix metalloproteinases (MMPs) are enzymes that are…”
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The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma by Kindt, Erick, Szekely-Klepser, Gabriella, Fountain, Scott T.

“…A simple plasma extraction method coupled with liquid chromatography–tandem mass spectrometry (LC/MS/MS) detection was developed and validated for the analysis…”
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Quantification and Rapid Metabolite Identification in Drug Discovery Using API Time-of-Flight LC/MS by Zhang, Nanyan, Fountain, Scott T, Bi, Honggang, Rossi, David T

“…Liquid chromatography/mass spectrometry (LC/MS), utilizing a time-of-flight (TOF) mass analyzer, has been evaluated and applied to problems in bioanalysis for…”
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A validated LC/MS/MS method for the quantification of pyrrole-2,3,5-tricarboxylic acid (PTCA), a eumelanin specific biomarker, in human skin punch biopsies by Szekely-Klepser, Gabriella, Wade, Kimberly, Woolson, Dayna, Brown, Richard, Fountain, Scott, Kindt, Erick

“…A novel skin tissue extraction method coupled with liquid chromatography-tandem mass spectrometry (LC/MS/MS) detection was developed and validated for the…”
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Development and Validation of an LC/MS/MS Procedure for the Quantification of Endogenous myo-Inositol Concentrations in Rat Brain Tissue Homogenates by Kindt, Erick, Shum, Yin, Badura, Lori, Snyder, Peter J, Brant, Ashley, Fountain, Scott, Szekely-Klepser, Gabriella

“…myo-Inositol is being investigated as a biomarker to monitor disease states involving the central nervous system. We have developed and validated a…”
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LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels by Althaus, John S, Schmidt, Kari R, Fountain, Scott T, Tseng, Michael T, Carroll, Richard T, Galatsis, Paul, Hall, Edward D

“…3-Nitrotyrosine (3NT) is used as a biomarker of nitrative pathology caused by peroxynitrite (PN), myeloperoxidase (MPO)–, and/or eosinophil peroxidase…”
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Development and validation of a semi-automated method for l-dopa and dopamine in rat plasma using electrospray LC/MS/MS by Li, Wenlin, Rossi, David T, Fountain, Scott T

“…A semi-automated alumina-based extraction method for the determination of l-dopa and dopamine in plasma using liquid chromatography/mass spectrometry was…”
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Investigation of EDTA anticoagulant in plasma to improve the throughput of liquid chromatography/tandem mass spectrometric assays by Sadagopan, Nalini P., Li, Wenlin, Cook, Jack A., Galvan, Betsy, Weller, David L., Fountain, Scott T., Cohen, Lucinda H.

“…In this study, EDTA and heparin are compared as anticoagulants with respect to their efficiency in preventing clot formation in plasma samples that were…”
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A quantitative LC–MS/MS approach for monitoring 2′-fluoro-2′-deoxy-D-glucose uptake in tumor tissue by Li, Wenlin, Zhang, Cathy, Huser, Nanni, Ray, Chad, Fountain, Scott, Kindt, Erick

“…Develop a quantitative LC–MS/MS method for FDG, FDG-monophosphate, glucose and glucose-monophosphate in mouse tumor models to assist in validating the use of […”
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Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates by Ji, Chengjie, Li, Wenlin, Ren, Xiao-dan, El-Kattan, Ayman F, Kozak, Rouba, Fountain, Scott, Lepsy, Christopher

“…The primary challenge associated with the development of an LC/MS/MS-based assay for simultaneous determination of biogenic monoamine neurotransmitters such as…”
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Wavelength-specific resonance-enhanced multiphoton ionization for isomer discrimination via fragmentation and metastable analysis by Fountain, Scott T, Lubman, David M

“…A study found that resonance-enhanced multiphoton ionization (REMPI) at two wavelengths can be used to produce fragmentation from which isomers can be…”
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11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation by Islam, Rafiq, Briscoe, Chad, Bower, Joseph, Cape, Stephanie, Arnold, Mark, Hayes, Roger, Warren, Mark, Karnik, Shane, Stouffer, Bruce, Xiao, Yi Qun, van der Strate, Barry, Sikkema, Daniel, Fang, Xinping, Tudoroniu, Ariana, Tayyem, Rabab, Brant, Ashley, Spriggs, Franklin, Barry, Colin, Khan, Masood, Keyhani, Anahita, Zimmer, Jennifer, Caturla, Maria Cruz, Couerbe, Philippe, Khadang, Ardeshir, Bourdage, James, Datin, Jim, Zemo, Jennifer, Hughes, Nicola, Fatmi, Saadya, Sheldon, Curtis, Fountain, Scott, Satterwhite, Christina, Colletti, Kelly, Vija, Jenifer, Yu, Mathilde, Stamatopoulos, John, Lin, Jenny, Wilfahrt, Jim, Dinan, Andrew, Ohorodnik, Susan, Hulse, James, Patel, Vimal, Garofolo, Wei, Savoie, Natasha, Brown, Michael, Papac, Damon, Buonarati, Mike, Hristopoulos, George, Beaver, Chris, Boudreau, Nadine, Williard, Clark, Liu, Yansheng, Ray, Gene, Warrino, Dominic, Xu, Allan, Green, Rachel, Hayward-Sewell, Joanne, Marcelletti, John, Sanchez, Christina, Kennedy, Michael, Charles, Jessica St, Bouhajib, Mohammed, Nehls, Corey, Tabler, Edward, Tu, Jing, Joyce, Philip, Iordachescu, Adriana, DuBey, Ira, Lindsay, John, Yamashita, Jim, Wells, Edward

“…The 11th Global CRO Council Closed Forum was held in Universal City, CA, USA on 3 April 2017. Representatives from international CRO members offering…”
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How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential by KRAYNOV, Eugenia, MARTIN, Steven W, AWWAD, Michel, WANG, Diane, HURST, Susan, FAHMI, Odette A, DOWTY, Martin, CRONENBERGER, Carol, LOI, Cho-Ming, KUANG, Bing, FIELDS, Owen, FOUNTAIN, Scott

“…Increasing use of therapeutic proteins (TPs) in polypharmacy settings calls for more in-depth understanding of the biological interactions that can lead to…”
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Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD by Neubert, Hendrik, Fountain, Scott, King, Lindsay, Clark, Tracey, Weng, Yan, O'Hara, Denise M, Li, Wenlin, Leung, Sheldon, Ray, Chad, Palandra, Joe, Ocaña, Mireia Fernández, Chen, Jianqing, Ji, Chengjie, Wang, Mengmeng, Long, Kimberly, Gorovits, Boris, Fluhler, Eric

“…Contemporary drug discovery leverages quantitative modeling and simulation with increasing emphasis, both to gain deeper knowledge of drug targets and…”
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How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential: TABLE 1 by Kraynov, Eugenia, Martin, Steven W., Hurst, Susan, Fahmi, Odette A., Dowty, Martin, Cronenberger, Carol, Loi, Cho-Ming, Kuang, Bing, Fields, Owen, Fountain, Scott, Awwad, Michel, Wang, Diane

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Ion fragmentation activated by matrix-assisted laser desorption/ionization in an ion-trap/reflectron time-of-flight device by Fountain, S T, Lee, H, Lubman, D M

“…An ion-trap storage/reflectron time-of-flight mass spectrometer has been used to study the decay of large ions following activation by matrix-assisted laser…”
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11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation by Islam, Rafiq, Briscoe, Chad, Bower, Joseph, Cape, Stephanie, Arnold, Mark, Hayes, Roger, Warren, Mark, Karnik, Shane, Stouffer, Bruce, Xiao, Yi Qun, van der Strate, Barry, Sikkema, Daniel, Fang, Xinping, Tudoroniu, Ariana, Tayyem, Rabab, Brant, Ashley, Spriggs, Franklin, Barry, Colin, Khan, Masood, Keyhani, Anahita, Zimmer, Jennifer, Caturla, Maria Cruz, Couerbe, Philippe, Khadang, Ardeshir, Bourdage, James, Datin, Jim, Zemo, Jennifer, Hughes, Nicola, Fatmi, Saadya, Sheldon, Curtis, Fountain, Scott, Satterwhite, Christina, Colletti, Kelly, Vija, Jenifer, Yu, Mathilde, Stamatopoulos, John, Lin, Jenny, Wilfahrt, Jim, Dinan, Andrew, Ohorodnik, Susan, Hulse, James, Patel, Vimal, Garofolo, Wei, Savoie, Natasha, Brown, Michael, Papac, Damon, Buonarati, Mike, Hristopoulos, George, Beaver, Chris, Boudreau, Nadine, Williard, Clark, Liu, Yansheng, Ray, Gene, Warrino, Dominic, Xu, Allan, Green, Rachel, Hayward-Sewell, Joanne, Marcelletti, John, Sanchez, Christina, Kennedy, Michael, Charles, Jessica St, Bouhajib, Mohammed, Nehls, Corey, Tabler, Edward, Tu, Jing, Joyce, Philip, Iordachescu, Adriana, DuBey, Ira, Lindsay, John, Yamashita, Jim, Wells, Edward

“…The 11th Global CRO Council Closed Forum was held in Universal City, CA, USA on 3 April 2017. Representatives from international CRO members offering…”
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Activation and fragmentation of peptides in time-of-flight mass spectrometry using optical and non-optical ionization sources by Fountain, Scott Timothy

“…Four ionization sources, including electron impact (EI), vacuum ultraviolet (VUV), resonance-enhanced multiphoton ionization (REMPI), and matrix-assisted laser…”
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