Search Results - "FOSTER, Martyn"

IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice by Botelho, Fernando M, Bauer, Carla M T, Finch, Donna, Nikota, Jake K, Zavitz, Caleb C J, Kelly, Ashling, Lambert, Kristen N, Piper, Sian, Foster, Martyn L, Goldring, James J P, Wedzicha, Jadwiga A, Bassett, Jennifer, Bramson, Jonathan, Iwakura, Yoichiro, Sleeman, Matthew, Kolbeck, Roland, Coyle, Anthony J, Humbles, Alison A, Stämpfli, Martin R

“…Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality…”
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Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection by Divolis, Georgios, Synolaki, Evgenia, Doulou, Athanasia, Gavriil, Ariana, Giannouli, Christina C, Apostolidou, Anastasia, Foster, Martyn L, Matzuk, Martin M, Skendros, Panagiotis, Galani, Ioanna-Evdokia, Sideras, Paschalis

“…Pre-neutrophils, while developing in the bone marrow, transcribe the gene and synthesize Activin-A protein, which they store and release at the earliest stage…”
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Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma by Matschiner, Gabriele, Fitzgerald, Mary F., Moebius, Ulrich, Hohlbaum, Andreas M., Gille, Hendrik, Jensen, Kristian, Kirchfeld, Klaus, Rattenstetter, Barbara, Laforge, Alice, Bel Aiba, Rachida S., Ciccotosto, Joe, Nyugen, Hong, Foster, Martyn L., Snouwaert, John N., Nguyen, MyTrang, Koller, Beverly H., Matis, Louis, Anderson, Gary P., Olwill, Shane A.

“…Type 2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle, and immunocytes…”
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Tissue-Specific Stem Cell Differentiation in an in vitro Airway Model by Prytherch, Zoë, Job, Claire, Marshall, Hilary, Oreffo, Victor, Foster, Martyn, BéruBé, Kelly

“…The respiratory tract is the primary site of exposure to airborne compounds, with the bronchial epithelium providing one of the first lines of defence. A…”
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Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders by Hagan, Suzanne, Fyfe, Matthew C T, Ofori-Frimpong, Boatemaa, Oliver, Katherine, Foster, Martyn R, Sirohi, Sameer, Solanke, Yemisi, Doughty, Michael, Rowley, Adele, Taylor, Mike, Webber, Steve, Walshe, Claire A

“…The purpose of this study is to determine the potential of narrow spectrum kinase inhibitors (NSKIs) to treat inflammatory eye disorders. Human conjunctival…”
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Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody by Topping, Louise M, Thomas, Bethan L, Rhys, Hefin I, Tremoleda, Jordi L, Foster, Martyn, Seed, Michael, Voisin, Mathieu-Benoit, Vinci, Chiara, Law, Hannah L, Perretti, Mauro, Norling, Lucy V, Azevedo, Helena S, Nissim, Ahuva

“…The targeted delivery of therapies to diseased tissues offers a safe opportunity to achieve optimal efficacy while limiting systemic exposure. These…”
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Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases by van der Linden, Maarten, Kumari, Sangeeta, Montizaan, Daphne, van Dalen, Stephanie, Kip, Annemarie, Foster, Martyn, Reinieren-Beeren, Inge, Neubert, Elsa, Erpenbeck, Luise, Waaijenberg, Kelsy, Bruurmijn, Tirza, Te Poele, Rezie, van Zandvoort, Peter, Vink, Paul, Meldrum, Eric, van Es, Helmuth, Chirivi, Renato G S

“…Neutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases. Targeting the NETosis pathway has…”
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Airway wall expression of OX40/OX40L and interleukin-4 in asthma by Siddiqui, Salman, Mistry, Vijay, Doe, Camille, Stinson, Sally, Foster, Martyn, Brightling, Christopher

“…The costimulatory molecule OX40 and its ligand, OX40L, mediate key aspects of allergic airway inflammation in animal models of asthma, including eosinophilic…”
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Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis by Biancheri, Paolo, Foster, Martyn R, Fyfe, Matthew C T, MacDonald, Thomas T, Sirohi, Sameer, Solanke, Yemisi, Wood, Eleanor, Rowley, Adele, Webber, Steve, Walshe, Claire A

“…Kinases are key mediators of inflammation, highlighting the potential of kinase inhibitors as treatments for inflammatory disorders. Selective kinase…”
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CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans by Campbell, John D, Cho, Yan, Foster, Martyn L, Kanzler, Holger, Kachura, Melissa A, Lum, Jeremy A, Ratcliffe, Marianne J, Sathe, Atul, Leishman, Andrew J, Bahl, Ash, McHale, Mark, Coffman, Robert L, Hessel, Edith M

“…CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to…”
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Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis by Krausz, Sarah, Garcia, Samuel, Ambarus, Carmen A, de Launay, Daphne, Foster, Martyn, Naiman, Brian, Iverson, William, Connor, Jane R, Sleeman, Matthew A, Coyle, Anthony J, Hamann, Jorg, Baeten, Dominique, Tak, Paul P, Reedquist, Kris A

“…Angiopoietin (Ang)-1 and Ang-2, and their shared receptor Tie2, are expressed in rheumatoid arthritis (RA) synovial tissue, but the cellular targets of Ang…”
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Isolation and characterisation of potential respiratory syncytial virus receptor(s) on epithelial cells by Malhotra, Rajneesh, Ward, Malcolm, Bright, Helen, Priest, Richard, Foster, Martyn R., Hurle, Michael, Blair, Eddie, Bird, Michael

“…Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in infancy, early childhood and the elderly. RSV infections respond poorly…”
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Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E2 production by HODGES, Rebecca J, JENKINS, R. Gisli, MCANULTY, Robin J, WHEELER-JONES, Caroline P. D, COPEMAN, Danielle M, BOTTOMS, Stephen E, BELLINGAN, Geoffrey J, NANTHAKUMAR, Carmel B, LAURENT, Geoffrey J, HART, Stephen L, FOSTER, Martyn L

“…Levels of prostaglandin E 2 (PGE 2 ), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been…”
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Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats by Bolton, Sarah J, Pinnion, Kate, Oreffo, Victor, Foster, Martyn, Pinkerton, Kent E

“…Continuous exposure to tobacco smoke (TS) is a key cause of chronic obstructive pulmonary disease (COPD), a complex multifactorial disease that is difficult to…”
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Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation Activity by Belvisi, Maria G, Wicks, Sharon L, Battram, Clifford H, Bottoms, Stephen E. W, Redford, Jane E, Woodman, Paul, Brown, Thomas J, Webber, Stephen E, Foster, Martyn L

“…Glucocorticoids (GCs) are the mainstay of asthma therapy; however, major side effects limit their therapeutic use. GCs influence the expression of genes either…”
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Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells by Beck, Lisa A, Tancowny, Brian, Brummet, Mary E, Asaki, S. Yukiko, Curry, Stephanie L, Penno, Margaret B, Foster, Martyn, Bahl, Ash, Stellato, Cristiana

“…The function of chemokine receptors on structural cells is only partially known. We previously reported the expression of a functional CCR3 receptor on airway…”
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Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma by Belvisi, Maria G, Bundschuh, Daniela S, Stoeck, Michael, Wicks, Sharon, Underwood, Stephen, Battram, Clifford H, Haddad, El-Bdaoui, Webber, Stephen E, Foster, Martyn L

“…Ciclesonide is a novel, inhaled corticosteroid under development for the treatment of asthma. Ciclesonide is activated to desisobutyryl-ciclesonide (des-CIC)…”
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Role of p38 MAP kinase in LPS‐induced airway inflammation in the rat by Haddad, El‐Bdaoui, Birrell, Mark, McCluskie, Kerryn, Ling, Andrea, Webber, Stephen E, Foster, Martyn L, Belvisi, Maria G

“…We investigated the effect of the p38 kinase inhibitor SB 203580 on airway inflammation induced by aerosolized lipopolysaccharide (LPS) in male Wistar rats. SB…”
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Differential Effects of Ebselen on Neutrophil Recruitment, Chemokine, and Inflammatory Mediator Expression in a Rat Model of Lipopolysaccharide-Induced Pulmonary Inflammation by Haddad, El-Bdaoui, McCluskie, Kerryn, Birrell, Mark A, Dabrowski, Dominika, Pecoraro, Michela, Underwood, Steve, Chen, Bei, De Sanctis, George T, Webber, Steve E, Foster, Martyn L, Belvisi, Maria G

“…We postulated that the seleno-organic compound ebselen would attenuate neutrophil recruitment and activation after aerosolized challenge with endotoxin (LPS)…”
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Modulation of β1-integrins on hemopoietic progenitor cells after allergen challenge in asthmatic subjects by Catalli, Adriana E., PhD, Thomson, Jennifer V., BSc, Babirad, Irene M., BSc, Duong, MyLinh, MD, Doyle, Tracey M., BSc, Howie, Karen J., BSc, Newbold, Paul, PhD, Craggs, Richard I., PhD, Foster, Martyn, PhD, Gauvreau, Gail M., PhD, O'Byrne, Paul M., MD, Sehmi, Roma, PhD

“…Background Mobilization of hemopoietic progenitor cells from the bone marrow (BM) is a feature of inflammatory asthmatic responses. Understanding the…”
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