Molecular cloning of major histocompatibility complex class I cDNAs from Atlantic salmon (Salmo salar)

Molecular cloning of major histocompatibility complex class I cDNAs from Atlantic salmon (Salmo salar)

The major histocompatibility complex (Mhc) has attracted much attention because of its immense polymorphism, its importance in transplantation, and its indisputable role in disease susceptibility in humans and in animals. Previously, typical Mhc features reflected in allograft rejection and mixed le...

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Bibliographic Details
Published in:Immunogenetics (New York) Vol. 37; no. 6; pp. 469 - 473
Main Authors: GRIMHOLT, U, HORDVIK, I, FOSSE, F. M, OLSAKER, I, ENDRESEN, C, LIE, Ø
Format: Journal Article
Language:English
Published: Heidelberg Springer 01-02-1993
Berlin
Subjects:
Amino Acid Sequence
Animals
Antigens
Base Sequence
Biological and medical sciences
Brackish
Cloning, Molecular
DNA - genetics
Freshwater
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes, MHC Class I
Histocompatibility antigens (hla, h-2 and other systems)
Major Histocompatibility Complex
Marine
Membrane Proteins - genetics
Molecular immunology
Molecular Sequence Data
Phylogeny
Salmo salar
Salmon - genetics
Salmon - immunology
Sequence Alignment
Species Specificity
Nucleotide sequence
Phylogenetic tree
Biological evolution
Salmo salar
Major histocompatibility system
Sequence alignment
Homology
Vertebrata
Pisces
Molecular cloning
Comparative study
Class I histocompatibility antigen
Aminoacid sequence
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Summary:The major histocompatibility complex (Mhc) has attracted much attention because of its immense polymorphism, its importance in transplantation, and its indisputable role in disease susceptibility in humans and in animals. Previously, typical Mhc features reflected in allograft rejection and mixed leucocyte reactivity were the only indications that an Mhc also existed in teleost fish. The use of polymerase chain reaction (PCR) with degenerate oligonucleotides from conserved Mhc regions provided the first direct evidence for Mhc class I and class II genes in a fish, the teleost carp. The primary aim of our study was to isolate and characterize expressed Mhc molecules in Atlantic salmon, and thereby provide data for further studies on evolutionary and disease aspects of the Mhc and its polymorphism.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0093-7711
1432-1211
DOI:10.1007/bf00222473