Search Results - "FOSS, Joseph F."

An overview of the cannabinoid type 2 receptor system and its therapeutic potential by Bie, Bihua, Wu, Jiang, Foss, Joseph F, Naguib, Mohamed

“…This narrative review summarizes recent insights into the role of the cannabinoid type 2 (CB2) receptor as potential therapeutic target in neuropathic pain and…”
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Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models by Bie, Bihua, Wu, Jiang, Foss, Joseph F., Naguib, Mohamed

“…Microglia and complements appear to be involved in the synaptic and cognitive deficits in Alzheimer’s disease (AD), though the mechanisms remain elusive. In…”
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Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post-ischemic pain model of complex regional pain syndrome type I in rats by Xu, Jijun, Tang, Yuying, Xie, Mian, Bie, Bihua, Wu, Jiang, Yang, Hui, Foss, Joseph F., Yang, Bin, Rosenquist, Richard W., Naguib, Mohamed

“…Complex regional pain syndrome type 1 (CRPS‐I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully…”
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Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease by Wu, Jiang, Hocevar, Mark, Foss, Joseph F., Bie, Bihua, Naguib, Mohamed

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuroinflammation, extensive deposits of amyloid-β aggregates, and loss of memory and…”
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Amyloid Fibril–Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses by Wu, Jiang, Bie, Bihua, Foss, Joseph F., Naguib, Mohamed

“…The complement C1q plays a critical role in microglial phagocytosis of glutamatergic synapses and in the pathogenesis of neuroinflammation in Alzheimer’s…”
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Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial by Yuan, Chun-Su, Wei, Gang, Foss, Joseph F, O'Connor, Michael, Karrison, Theodore, Osinski, Joachim

“…Methylnaltrexone, the first peripheral opioid receptor antagonist, has the potential to prevent or reverse opioid-induced peripherally mediated side effects…”
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Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses by Bie, Bihua, Wu, Jiang, Foss, Joseph F., Naguib, Mohamed

“…Silent glutamatergic synapses lacking functional AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazoleproprionate) receptors exist in several brain regions including…”
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Medical Use of Marijuana: Truth in Evidence by Naguib, Mohamed, Foss, Joseph F.

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Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability by Viscusi, Eugene R., Gan, Tong J., Leslie, John B., Foss, Joseph F., Talon, Mark D., Du, Wei, Owens, Gay

“…Postoperative ileus (POI), a transient cessation of coordinated bowel function after surgery, is an important health care problem. The etiology of POI is…”
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A Review of the Potential Role of Methylnaltrexone in Opioid Bowel Dysfunction by Foss, Joseph F

“…Opioids are widely used analgesics in patients with advanced cancer. However, their effectiveness for pain relief is often limited by the most frequently…”
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Methylnaltrexone for Reversal of Constipation Due to Chronic Methadone Use: A Randomized Controlled Trial by Yuan, Chun-Su, Foss, Joseph F, O'Connor, Michael, Osinski, Joachim, Karrison, Theodore, Moss, Jonathan, Roizen, Michael F

“…CONTEXT Constipation is the most common chronic adverse effect of opioid pain medications in patients who require long-term opioid administration, such as…”
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Are Peripheral Opioid Antagonists the Solution to Opioid Side Effects? by Bates, John J., Foss, Joseph F., Murphy, Damian B.

“…Opioid medication is the mainstay of therapy for severe acute and chronic pain. Unfortunately, the side effects of these medications can affect patient comfort…”
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Development and use of methylnaltrexone, a peripherally acting opioid antagonist, to treat side effects related to opioid use by Yuan, Chun-Su, Foss, Joseph F., Williams, Wade A., Moss, Jonathan

“…Opioid medications are used extensively as potent analgesics for treating moderate to severe pain. Although opioids offer reliable pain relief, their use is…”
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Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial by Yuan, C S, Foss, J F, O'Connor, M, Toledano, A, Roizen, M F, Moss, J

“…Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood-brain barrier and the potential to antagonize the peripherally…”
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The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time by Yuan, Chun‐Su, Foss, Joseph F., Osinski, Joachim, Toledano, Alicia, Roizen, Michael F., Moss, Jonathan

“…Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood‐brain barrier that has the potential to antagonize the peripherally…”
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Effects of Low-Dose Morphine on Gastric Emptying in Healthy Volunteers by Yuan, Chun-Su, Foss, Joseph F., O'Connor, Michael, Roizen, Michael F., Moss, Jonathan

“…Appropriate preoperative pain therapy for patients undergoing surgery may be withheld due to the fear that opioids will inhibit gastric emptying and increase…”
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Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine by Yuan, Chun-Su, Foss, Joseph F, O'Connor, Michael, Osinski, Joachim, Roizen, Michael F, Moss, Jonathan

“…Opioid compounds are commonly used analgesics. After opioid administration, troublesome subjective effects, such as dysphoria, dizziness, nausea, and pruritus,…”
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Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study by Osinski, Joachim, Wang, Anbao, Wu, Ji An, Foss, Joseph F, Yuan, Chun-Su

“…A high-performance liquid chromatographic (HPLC) method with electrochemical detection and solid-phase extraction (SPE) using cartridges of weak…”
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Antagonism of gastrointestinal opioid effects by Yuan, Chun-Su, Foss, Joseph F.

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Antagonism of Gastrointestinal Opioid Effects by Yuan, Chun-Su, Foss, Joseph F.

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