Search Results - "FORTUNATO, STEPHEN J."

Amniotic Fluid Exosome Proteomic Profile Exhibits Unique Pathways of Term and Preterm Labor by Dixon, C Luke, Sheller-Miller, Samantha, Saade, George R, Fortunato, Stephen J, Lai, Andrew, Palma, Carlos, Guanzon, Dominic, Salomon, Carlos, Menon, Ramkumar

“…Our objective was to determine the amniotic fluid-derived exosomal proteomic profile in patients who had spontaneous preterm birth (PTB) or preterm premature…”
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Chorioamniotic membrane senescence: a signal for parturition? by Behnia, Faranak, MD, Taylor, Brandie D., PhD, Woodson, Michael, PhD, Kacerovsky, Marian, MD, PhD, Hawkins, Hal, MD, PhD, Fortunato, Stephen J., MD, Saade, George R., MD, Menon, Ramkumar, MS, PhD

“…Objective Senescence is an important biological phenomenon involved in both physiologic and pathologic processes. We propose that chorioamniotic membrane…”
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Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age by Parets, Sasha E, Conneely, Karen N, Kilaru, Varun, Fortunato, Stephen J, Syed, Tariq Ali, Saade, George, Smith, Alicia K, Menon, Ramkumar

“…Spontaneous preterm birth (PTB, <37 weeks gestation) is a major public health concern, and children born preterm have a higher risk of morbidity and mortality…”
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Infection and the role of inflammation in preterm premature rupture of the membranes by Menon, Ramkumar, MS, Fortunato, Stephen J., MD

“…Spontaneous preterm birth, caused by preterm labor (contractions before 37 weeks' gestation) or preterm premature rupture of the membranes (pPROM) (membrane…”
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Diversity in cytokine response to bacteria associated with preterm birth by fetal membranes by Menon, Ramkumar, PhD, Peltier, Morgan R., PhD, Eckardt, Judith, MD, Fortunato, Stephen J., MD

“…Objective This study compared cytokine and prostaglandin (PG) responses by fetal membranes stimulated with 4 different bacterial species associated with…”
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An overview of racial disparities in preterm birth rates: caused by infection or inflammatory response? by Menon, Ramkumar, Dunlop, Anne L, Kramer, Michael R, Fortunato, Stephen J, Hogue, Carol J

“…Infection has been hypothesized to be one of the factors associated with spontaneous preterm birth (PTB) and with the racial disparity in rates of PTB between…”
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Distinct pathophysiologic pathways induced by in vitro infection and cigarette smoke in normal human fetal membranes by Menon, Ramkumar, PhD, Fortunato, Stephen J., MD

“…Objective The purpose of this study was to document distinct pathways that are initiated by lipopolysaccharide and cigarette smoke stimulation of normal term…”
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Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants by Velez, Digna R, Fortunato, Stephen J, Thorsen, Poul, Lombardi, Salvatore J, Williams, Scott M, Menon, Ramkumar

“…Spontaneous preterm birth (<37 weeks gestation-PTB) occurs in approximately 12% of pregnancies in the United States, and is the largest contributor to neonatal…”
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Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes by Menon, Ramkumar, Yu, Jie, Basanta-Henry, Patrice, Brou, Lina, Berga, Sarah L, Fortunato, Stephen J, Taylor, Robert N

“…Rupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS) and…”
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Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans by Menon, Ramkumar, PhD, Camargo, M. Constanza, MS, Thorsen, Poul, MD, PhD, Lombardi, Salvatore J., MD, Fortunato, Stephen J., MD

“…Objective This study examined the differences in the inflammatory cytokine interleukin (IL)-6 and the immunoinhibitory cytokine IL-10 in the amniotic fluid of…”
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Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants by Menon, Ramkumar, Pearce, Brad, Velez, Digna R, Merialdi, Mario, Williams, Scott M, Fortunato, Stephen J, Thorsen, Poul

“…To study pathophysiologic pathways in spontaneous preterm birth and possibly the racial disparity associating with maternal and fetal genetic variations, using…”
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Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth by Ryckman, Kelli K, Morken, Nils-Halvdan, White, Marquitta J, Velez, Digna R, Menon, Ramkumar, Fortunato, Stephen J, Magnus, Per, Williams, Scott M, Jacobsson, Bo

“…The purpose of this study was to identify associations between maternal and fetal genetic variants in candidate genes and spontaneous preterm birth (PTB) in a…”
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Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth by Menon, Ramkumar, PhD, Thorsen, Poul, MD, PhD, Vogel, Ida, MD, PhD, Jacobsson, Bo, MD, PhD, Morgan, Nicole, BA, Jiang, Lan, MS, Li, Chun, PhD, Williams, Scott M., PhD, Fortunato, Stephen J., MD

“…Objective Preterm birth rate in the United States is higher in blacks than whites. It has been hypothesized that a differential inflammatory response may…”
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Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro by Menon, Ramkumar, Boldogh, Istvan, Hawkins, Hal K, Woodson, Michael, Polettini, Jossimara, Syed, Tariq Ali, Fortunato, Stephen J, Saade, George R, Papaconstantinou, John, Taylor, Robert N

“…Preterm prelabor rupture of the membranes (pPROM) may lead to preterm births (PTBs). We investigated premature senescence of fetal membranes in women with…”
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Quantitative Proteomics by SWATH-MS of Maternal Plasma Exosomes Determine Pathways Associated With Term and Preterm Birth by Menon, Ramkumar, Dixon, Christopher Luke, Sheller-Miller, Samantha, Fortunato, Stephen J, Saade, George R, Palma, Carlos, Lai, Andrew, Guanzon, Dominic, Salomon, Carlos

“…Exosomes are membrane-bound nanovesicles that transport molecular signals between cells. This study determined changes in maternal plasma exosome proteomics…”
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Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birth by Fortunato, Stephen J., MD, Menon, Ramkumar, PhD, Velez, Digna R., PhD, Thorsen, Poul, MD, PhD, Williams, Scott M., PhD

“…Objective To understand the differences in genetic interactions among tumor necrosis factor-alpha, interleukin-6 and their receptor gene variants between black…”
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Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy by Richardson, Lauren S, K Kammala, Ananth, Costantine, Maged M, Fortunato, Stephen J, Radnaa, Enkhtuya, Kim, Sungjin, Taylor, Robert N, Han, Arum, Menon, Ramkumar

“…: To improve preclinical drug testing during pregnancy, we developed multiple microfluidic organ-on-chip (OOC) devices that represent the structure, functions,…”
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Perinatal Sepsis Caused by Williamsia serinedens Infection in a 31-Year-Old Pregnant Woman by Yassin, Atteyet F, Lombardi, Salvatore J, Fortunato, Stephen J, McNabb, Paul C, Carr, Mark B, Trabue, Christopher H

“…Williamsia serinedens has been isolated from soil but has not yet been implicated in human disease. We report the first case of perinatal sepsis caused by a…”
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Salivary proteinase activity: A potential biomarker for preterm premature rupture of the membranes by Menon, Ramkumar, McIntyre, J. Oliver, Matrisian, Lynn M., Fortunato, Stephen J.

“…The objective of this study was to design a method to identify patients at risk for preterm premature rupture of the membranes using a simple assay of salivary…”
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Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response by Kammala, Ananth Kumar, Mosebarger, Angela, Radnaa, Enkhtuya, Rowlinson, Emma, Vora, Natasha, Fortunato, Stephen J., Sharma, Surendra, Safarzadeh, Melody, Menon, Ramkumar

“…BackgroundFetal inflammatory response mediated by the influx of immune cells and activation of pro-inflammatory transcription factor NF-κB in feto-maternal…”
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