Search Results - "FOROUD, T"

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study by Ramanan, V K, Risacher, S L, Nho, K, Kim, S, Swaminathan, S, Shen, L, Foroud, T M, Hakonarson, H, Huentelman, M J, Aisen, P S, Petersen, R C, Green, R C, Jack, C R, Koeppe, R A, Jagust, W J, Weiner, M W, Saykin, A J

“…Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in Alzheimer’s disease (AD) pathogenesis with a significant genetic…”
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Genetic risk for schizophrenia and psychosis in Alzheimer disease by DeMichele-Sweet, M A A, Weamer, E A, Klei, L, Vrana, D T, Hollingshead, D J, Seltman, H J, Sims, R, Foroud, T, Hernandez, I, Moreno-Grau, S, Tárraga, L, Boada, M, Ruiz, A, Williams, J, Mayeux, R, Lopez, O L, Sibille, E L, Kamboh, M I, Devlin, B, Sweet, R A

“…Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with…”
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Inflammatory profile discriminates clinical subtypes in LRRK2‐associated Parkinson's disease by Brockmann, K., Schulte, C., Schneiderhan‐Marra, N., Apel, A., Pont‐Sunyer, C., Vilas, D., Ruiz‐Martinez, J., Langkamp, M., Corvol, J.‐C., Cormier, F., Knorpp, T., Joos, T. O., Bernard, A., Gasser, T., Marras, C., Schüle, B., Aasly, J. O., Foroud, T., Marti‐Masso, J. F., Brice, A., Tolosa, E., Berg, D., Maetzler, W.

“…Background and purpose The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2) is highly variable, suggesting a strong…”
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Genome-wide association study of CSF biomarkers Aβ1-42, t-tau, and p-tau181p in the ADNI cohort by KIM, S, SWAMINATHAN, S, CRAIG, D. W, DECHAIRO, B. M, AISEN, P. S, PETERSEN, R. C, WEINER, M. W, SAYKIN, A. J, SHEN, L, RISACHER, S. L, NHO, K, FOROUD, T, SHAW, L. M, TROJANOWSKI, J. Q, POTKIN, S. G, HUENTELMAN, M. J

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ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry by Bierut, L J, Goate, A M, Breslau, N, Johnson, E O, Bertelsen, S, Fox, L, Agrawal, A, Bucholz, K K, Grucza, R, Hesselbrock, V, Kramer, J, Kuperman, S, Nurnberger, J, Porjesz, B, Saccone, N L, Schuckit, M, Tischfield, J, Wang, J C, Foroud, T, Rice, J P, Edenberg, H J

“…A coding variant in alcohol dehydrogenase 1B ( ADH1B ) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces…”
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The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences by Meyers, J. L., Chorlian, D. B., Bigdeli, T. B., Johnson, E. C., Aliev, F., Agrawal, A., Almasy, L., Anokhin, A., Edenberg, H. J., Foroud, T., Goate, A., Kamarajan, C., Kinreich, S., Nurnberger, J., Pandey, A. K., Pandey, G., Plawecki, M. H., Salvatore, J. E., Zhang, J., Fanous, A., Porjesz, B.

“…Neurodevelopmental abnormalities in neural connectivity have been long implicated in the etiology of schizophrenia (SCZ); however, it remains unclear whether…”
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Genome-wide association study of bipolar disorder in European American and African American individuals by Smith, E N, Bloss, C S, Badner, J A, Barrett, T, Belmonte, P L, Berrettini, W, Byerley, W, Coryell, W, Craig, D, Edenberg, H J, Eskin, E, Foroud, T, Gershon, E, Greenwood, T A, Hipolito, M, Koller, D L, Lawson, W B, Liu, C, Lohoff, F, McInnis, M G, McMahon, F J, Mirel, D B, Murray, S S, Nievergelt, C, Nurnberger, J, Nwulia, E A, Paschall, J, Potash, J B, Rice, J, Schulze, T G, Scheftner, W, Panganiban, C, Zaitlen, N, Zandi, P P, Zöllner, S, Schork, N J, Kelsoe, J R

“…To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals…”
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Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset by NICHOLS, W. C, PANKRATZ, N, MAREK, D. K, PAUCIULO, M. W, ELSAESSER, V. E, HALTER, C. A, RUDOLPH, A, WOJCIESZEK, J, PFEIFFER, R. F, FOROUD, T

“…To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD)…”
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Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100 by Schneider, B P, Li, L, Shen, F, Miller, K D, Radovich, M, O'Neill, A, Gray, R J, Lane, D, Flockhart, D A, Jiang, G, Wang, Z, Lai, D, Koller, D, Pratt, J H, Dang, C T, Northfelt, D, Perez, E A, Shenkier, T, Cobleigh, M, Smith, M L, Railey, E, Partridge, A, Gralow, J, Sparano, J, Davidson, N E, Foroud, T, Sledge, G W

“…Background: Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting…”
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Genome-wide association study identifies a novel locus for cannabis dependence by Agrawal, A, Chou, Y-L, Carey, C E, Baranger, D A A, Zhang, B, Sherva, R, Wetherill, L, Kapoor, M, Wang, J-C, Bertelsen, S, Anokhin, A P, Hesselbrock, V, Kramer, J, Lynskey, M T, Meyers, J L, Nurnberger, J I, Rice, J P, Tischfield, J, Bierut, L J, Degenhardt, L, Farrer, L A, Gelernter, J, Hariri, A R, Heath, A C, Kranzler, H R, Madden, P A F, Martin, N G, Montgomery, G W, Porjesz, B, Wang, T, Whitfield, J B, Edenberg, H J, Foroud, T, Goate, A M, Bogdan, R, Nelson, E C

“…Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of…”
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The Alzheimer's Disease Sequencing Project: Study design and sample selection by Beecham, Gary W, Bis, J C, Martin, E R, Choi, S-H, DeStefano, A L, van Duijn, C M, Fornage, M, Gabriel, S B, Koboldt, D C, Larson, D E, Naj, A C, Psaty, B M, Salerno, W, Bush, W S, Foroud, T M, Wijsman, E, Farrer, L A, Goate, A, Haines, J L, Pericak-Vance, Margaret A, Boerwinkle, E, Mayeux, R, Seshadri, S, Schellenberg, G

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Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease by HAUGARVOLL, K, RADEMAKERS, R, GUIDI, M, RIBOLDAZZI, G, BROWN, L, WALTER, U, BENECKE, R, BERG, D, GASSER, T, THEUNS, J, PALS, P, CRAS, P, KACHERGUS, J. M, DE DEYN, P. Paul, ENGELBORGHS, S, PICKUT, B, UITTI, R. J, FOROUD, T, NICHOLS, W. C, HAGENAH, J, KLEIN, C, SAMII, A, ZABETIAN, C. P, NUYTEMANS, K, BONIFATI, V, VAN BROECKHOVEN, C, FARRER, M. J, WSZOLEK, Z. K, ROSS, O. A, GIBSON, J. M, TAN, E.-K, GAIG, C, TOLOSA, E, GOLDWURM, S

“…Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson disease (PD). Several dominantly inherited pathogenic substitutions have…”
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Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP) by Reitz, C, Tosto, G, Vardarajan, B, Rogaeva, E, Ghani, M, Rogers, R S, Conrad, C, Haines, J L, Pericak-Vance, M A, Fallin, M D, Foroud, T, Farrer, L A, Schellenberg, G D, George-Hyslop, P S, Mayeux, R

“…Genetic variants in the sortilin-related receptor ( SORL1 ) and the sortilin-related vacuolar protein sorting 10 (VPS10) domain-containing receptor 1 ( SORCS1…”
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An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry by Meyers, J L, Zhang, J, Wang, J C, Su, J, Kuo, S I, Kapoor, M, Wetherill, L, Bertelsen, S, Lai, D, Salvatore, J E, Kamarajan, C, Chorlian, D, Agrawal, A, Almasy, L, Bauer, L, Bucholz, K K, Chan, G, Hesselbrock, V, Koganti, L, Kramer, J, Kuperman, S, Manz, N, Pandey, A, Seay, M, Scott, D, Taylor, R E, Dick, D M, Edenberg, H J, Goate, A, Foroud, T, Porjesz, B

“…Fast beta (20–28 Hz) electroencephalogram (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders characterized by…”
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Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment by Nho, K, Corneveaux, J J, Kim, S, Lin, H, Risacher, S L, Shen, L, Swaminathan, S, Ramanan, V K, Liu, Y, Foroud, T, Inlow, M H, Siniard, A L, Reiman, R A, Aisen, P S, Petersen, R C, Green, R C, Jack, C R, Weiner, M W, Baldwin, C T, Lunetta, K, Farrer, L A, Furney, S J, Lovestone, S, Simmons, A, Mecocci, P, Vellas, B, Tsolaki, M, Kloszewska, I, Soininen, H, McDonald, B C, Farlow, M R, Ghetti, B, Huentelman, M J, Saykin, A J

“…Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the…”
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Correction: Genetic risk for schizophrenia and psychosis in Alzheimer disease by DeMichele-Sweet, M. A. A., Weamer, E. A., Klei, L., Vrana, D. T., Hollingshead, D. J., Seltman, H. J., Sims, R., Foroud, T., Hernandez, I., Moreno-Grau, S., Tárraga, L., Boada, M., Ruiz, A., Williams, J., Mayeux, R., Lopez, O. L., Sibille, E. L., Kamboh, M. I., Devlin, B., Sweet, R. A.

“…A number of collaborators were not acknowledged for their contribution to this published article. The acknowledgements that were missing in this published…”
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Association of the κ-opioid system with alcohol dependence by XUEI, X, DICK, D, TISCHFIELD, J, KUPERMAN, S, PORJESZ, B, BEGLEITER, H, FOROUD, T, EDENBERG, H. J, FLURY-WETHERILL, L, TIAN, H.-J, AGRAWAL, A, BIERUT, L, GOATE, A, BUCHOLZ, K, SCHUCKIT, M, NURNBERGER, J

“…Opioid receptors and their endogenous peptide ligands play important roles in the reward and reinforcement of drugs such as heroin, cocaine, and alcohol. The…”
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Singleton deletions throughout the genome increase risk of bipolar disorder by Zhang, D, Cheng, L, Qian, Y, Alliey-Rodriguez, N, Kelsoe, J R, Greenwood, T, Nievergelt, C, Barrett, T B, McKinney, R, Schork, N, Smith, E N, Bloss, C, Nurnberger, J, Edenberg, H J, Foroud, T, Sheftner, W, Lawson, W B, Nwulia, E A, Hipolito, M, Coryell, W, Rice, J, Byerley, W, McMahon, F, Schulze, T G, Berrettini, W, Potash, J B, Belmonte, P L, Zandi, P P, McInnis, M G, Zöllner, S, Craig, D, Szelinger, S, Koller, D, Christian, S L, Liu, C, Gershon, E S

“…An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with…”
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FASTKD2 is associated with memory and hippocampal structure in older adults by Ramanan, V K, Nho, K, Shen, L, Risacher, S L, Kim, S, McDonald, B C, Farlow, M R, Foroud, T M, Gao, S, Soininen, H, Kłoszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Lovestone, S, Aisen, P S, Petersen, R C, Jack, C R, Shaw, L M, Trojanowski, J Q, Weiner, M W, Green, R C, Toga, A W, De Jager, P L, Yu, L, Bennett, D A, Saykin, A J

“…Memory impairment is the cardinal early feature of Alzheimer’s disease, a highly prevalent disorder whose causes remain only partially understood. To identify…”
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Saccades in presymptomatic and early stages of Huntington disease by BLEKHER, T, JOHNSON, S. A, WOJCIESZEK, J, FOROUD, T, MARSHALL, J, WHITE, K, HUI, S, WEAVER, M, GRAY, J, YEE, R, STOUT, J. C, BERISTAIN, X

“…To evaluate quantitative measures of eye movements as possible biomarkers in prediagnostic and early stages of Huntington disease (HD). The study sample (n =…”
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