Search Results - "FORNEROD, M"

miR-139-5p controls translation in myeloid leukemia through EIF4G2 by Emmrich, S, Engeland, F, El-Khatib, M, Henke, K, Obulkasim, A, Schöning, J, Katsman-Kuipers, J E, Michel Zwaan, C, Pich, A, Stary, J, Baruchel, A, de Haas, V, Reinhardt, D, Fornerod, M, van den Heuvel-Eibrink, M M, Klusmann, J H

“…MicroRNAs (miRNAs) are crucial components of homeostatic and developmental gene regulation. In turn, dysregulation of miRNA expression is a common feature of…”
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miR-9 is a tumor suppressor in pediatric AML with t(8;21) by Emmrich, S, Katsman-Kuipers, J E, Henke, K, Khatib, M E, Jammal, R, Engeland, F, Dasci, F, Zwaan, C M, den Boer, M L, Verboon, L, Stary, J, Baruchel, A, de Haas, V, Danen-van Oorschot, A A, Fornerod, M, Pieters, R, Reinhardt, D, Klusmann, J H, van den Heuvel-Eibrink, M M

“…MicroRNAs (miRNAs) play a pivotal role in the regulation of hematopoiesis and development of leukemia. Great interest emerged in modulating miRNA expression…”
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MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML by Larmonie, N S D, Arentsen-Peters, T C J M, Obulkasim, A, Valerio, D, Sonneveld, E, Danen-van Oorschot, A A, de Haas, V, Reinhardt, D, Zimmermann, M, Trka, J, Baruchel, A, Pieters, R, van den Heuvel-Eibrink, M M, Zwaan, C M, Fornerod, M

“…In acute myeloid leukemia (AML), specific genomic aberrations induce aberrant methylation, thus directly influencing the transcriptional programing of leukemic…”
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A new function of ROD1 in nonsense-mediated mRNA decay by Brazão, T.F., Demmers, J., van IJcken, W., Strouboulis, J., Fornerod, M., Romão, L., Grosveld, F.G.

“…► ROD1 is involved in nonsense-mediated mRNA decay (NMD). ► ROD1 is shown to interact with core NMD factors, such as UPF1 and UPF2, and to share common…”
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C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation by Marneth, A E, Prange, K H M, Al Hinai, A S A, Bergevoet, S M, Tesi, N, Janssen-Megens, E M, Kim, B, Sharifi, N, Yaspo, M L, Kuster, J, Sanders, M A, Stoetman, E C G, Knijnenburg, J, Arentsen-Peters, T C J M, Zwaan, C M, Stunnenberg, H G, van den Heuvel-Eibrink, M M, Haferlach, T, Fornerod, M, Jansen, J H, Valk, P J M, van der Reijden, B A, Martens, J H A

“…Overexpression of the BRE ( brain and reproductive organ-expressed ) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we…”
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BCOR and BCORL1 mutations in pediatric acute myeloid leukemia by de Rooij, Jasmijn D E, van den Heuvel-Eibrink, Marry M, Hermkens, Malou C H, Verboon, Lonneke J, Arentsen-Peters, Susan T C J M, Fornerod, Maarten, Baruchel, Andre, Stary, Jan, Reinhardt, Dirk, de Haas, Valerie, Pieters, Rob, Zwaan, C Michel

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88 by Fornerod, Maarten, van Deursen, Jan, van Baal, Sjozef, Reynolds, Albert, Davis, Donna, Murti, K.Gopal, Fransen, Jack, Grosveld, Gerard

“…The oncogenic nucleoporin CAN/Nup214 is essential in vertebrate cells. Its depletion results in defective nuclear protein import, inhibition of messenger RNA…”
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Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis by Bonten, E, van der Spoel, A, Fornerod, M, Grosveld, G, d'Azzo, A

“…Neuraminidases (sialidases) have an essential role in the removal of terminal sialic acid residues from sialoglycoconjugates and are distributed widely in…”
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Cre-Mediated Site-Specific Translocation between Nonhomologous Mouse Chromosomes by van Deursen, J., Fornerod, M., van Rees, B., Grosveld, G.

“…Chromosome rearrangements, such as large deletions, inversions, or translocations, mediate migration of large DNA segments within or between chromosomes, which…”
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The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA by VON LINDERN, M, FORNEROD, M, VAN BAAL, S, JAEGLE, M, DE WIT, T, BUIJS, A, GROSVELD, G

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition by Fortes, P, Bilbao-Cortés, D, Fornerod, M, Rigaut, G, Raymond, W, Séraphin, B, Mattaj, I W

“…The characterization of a novel yeast-splicing factor, Luc7p, is presented. The LUC7 gene was identified by a mutation that causes lethality in a yeast strain…”
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Analysis of rare driving events in pediatric acute myeloid leukemia by Noort, Sanne, Oosterwijk, Jolieke van, Ma, Jing, Garfinkle, Elizabeth A R, Nance, Stephanie, Walsh, Michael, Song, Guangchun, Reinhardt, Dirk, Pigazzi, Martina, Locatelli, Franco, Hasle, Henrik, Abrahamsson, Jonas, Jarosova, Marie, Kelaidi, Charikleia, Polychronopoulou, Sophia, Van den Heuvel-Eibrink, Marry M, Fornerod, Maarten, Gruber, Tanja A, Zwaan, C Michel

“…Elucidating genetic aberrations in pediatric acute myeloid leukemia (AML) provides insight in biology and may impact on risk-group stratification and clinical…”
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t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients by Sandahl, Julie Damgaard, Coenen, Eva A, Forestier, Erik, Harbott, Jochen, Johansson, Bertil, Kerndrup, Gitte, Adachi, Souichi, Auvrignon, Anne, Beverloo, H Berna, Cayuela, Jean-Michel, Chilton, Lucy, Fornerod, Maarten, de Haas, Valérie, Harrison, Christine J, Inaba, Hiroto, Kaspers, Gertjan J L, Liang, Der-Cherng, Locatelli, Franco, Masetti, Riccardo, Perot, Christine, Raimondi, Susana C, Reinhardt, Katarina, Tomizawa, Daisuke, von Neuhoff, Nils, Zecca, Marco, Zwaan, C Michel, van den Heuvel-Eibrink, Marry M, Hasle, Henrik

“…Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the…”
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals by Fornerod, Maarten, Ohno, Mutsuhito, Yoshida, Minoru, Mattaj, Iain W.

“…CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression…”
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Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia by de Rooij, Jasmijn D E, Beuling, Eva, van den Heuvel-Eibrink, Marry M, Obulkasim, Askar, Baruchel, André, Trka, Jan, Reinhardt, Dirk, Sonneveld, Edwin, Gibson, Brenda E S, Pieters, Rob, Zimmermann, Martin, Zwaan, C Michel, Fornerod, Maarten

“…IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia…”
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Nup358/RanBP2 Attaches to the Nuclear Pore Complex via Association with Nup88 and Nup214/CAN and Plays a Supporting Role in CRM1-Mediated Nuclear Protein Export by Bernad, Rafael, van der Velde, Hella, Fornerod, Maarten, Pickersgill, Helen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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C-terminal BRE overexpression in 11q23-rearranged and t by Jansen, J H, Prange, K H M, Arentsen-Peters, T C J M, van der Reijden, B A, Bergevoet, S M, Valk, P J M, Marneth, A E, Tesi, N, Sanders, M A, Stoetman, E C G, Al Hinai, A S A, Janssen-Megens, E M, Knijnenburg, J, Zwaan, C M, Sharifi, N, Haferlach, T, Kuster, J, van den Heuvel-Eibrink, M M, Martens, J H A, Yaspo, M L, Kim, B, Fornerod, M, Stunnenberg, H G

“…Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we…”
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Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358 by Engelsma, Dieuwke, Bernad, Rafael, Calafat, Jero, Fornerod, Maarten

“…Leucine‐rich nuclear export signals (NESs) mediate rapid nuclear export of proteins via interaction with CRM1. This interaction is stimulated by RanGTP but…”
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Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 by Trotman, Lloyd C, Mosberger, Nicole, Fornerod, Maarten, Stidwill, Robert P, Greber, Urs F

“…Adenovirus type 2 (Ad2) imports its DNA genome through the nuclear pore complex (NPC) of cells in interphase for viral production. Here we identify the…”
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Translation controls the expression level of chimaeric reporter gene by Hensgens, L.A.M. (Leiden Univ. (Netherlands). Inst. of Molecular Plant Sciences), Fornerod, M.W.J, Rueb, S, Winkler, A.A, Veen, S. van der, Schilperoort, R.A

“…Transcriptional and translational fusions between the reading frame of the beta-D-glucuronidase gene (gusA) and the 2' as well as the 1' promoter of mannopine…”
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