Search Results - "FORNARO, Lorenzo"

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis by Crea, Francesco, Fornaro, Lorenzo, Bocci, Guido, Sun, Lei, Farrar, William L., Falcone, Alfredo, Danesi, Romano

“…Tumor angiogenesis and metastatic spreading are two highly interconnected phenomena, which contribute to cancer-associated deaths. Thus, the identification of…”
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Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer by Del Re, Marzia, Vivaldi, Caterina, Rofi, Eleonora, Vasile, Enrico, Miccoli, Mario, Caparello, Chiara, d’Arienzo, Paolo Davide, Fornaro, Lorenzo, Falcone, Alfredo, Danesi, Romano

“…Pancreatic cancer (PDAC) is still lacking of reliable markers to monitor tumor response. CA 19-9 is the only biomarker approved, despite it has several…”
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Pembrolizumab versus paclitaxel for previously treated PD-L1-positive advanced gastric or gastroesophageal junction cancer: 2-year update of the randomized phase 3 KEYNOTE-061 trial by Fuchs, Charles S., Özgüroğlu, Mustafa, Bang, Yung-Jue, Di Bartolomeo, Maria, Mandala, Mario, Ryu, Min-Hee, Fornaro, Lorenzo, Olesinski, Tomasz, Caglevic, Christian, Chung, Hyun C., Muro, Kei, Van Cutsem, Eric, Elme, Anneli, Thuss-Patience, Peter, Chau, Ian, Ohtsu, Atsushi, Bhagia, Pooja, Wang, Anran, Shih, Chie-Schin, Shitara, Kohei

“…Background In the phase 3 KEYNOTE-061 study (cutoff: 10/26/2017), pembrolizumab did not significantly prolong OS vs paclitaxel as second-line (2L) therapy in…”
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The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib by Caputo, Francesco, Dadduzio, Vincenzo, Tovoli, Francesco, Bertolini, Giulia, Cabibbo, Giuseppe, Cerma, Krisida, Vivaldi, Caterina, Faloppi, Luca, Rizzato, Mario Domenico, Piscaglia, Fabio, Celsa, Ciro, Fornaro, Lorenzo, Marisi, Giorgia, Conti, Fabio, Silvestris, Nicola, Silletta, Marianna, Lonardi, Sara, Granito, Alessandro, Stornello, Caterina, Massa, Valentina, Astara, Giorgio, Delcuratolo, Sabina, Cascinu, Stefano, Scartozzi, Mario, Casadei-Gardini, Andrea

“…The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC)…”
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The prognostic nutritional index predicts survival and response to first‐line chemotherapy in advanced biliary cancer by Salati, Massimiliano, Filippi, Roberto, Vivaldi, Caterina, Caputo, Francesco, Leone, Francesco, Salani, Francesca, Cerma, Krisida, Aglietta, Massimo, Fornaro, Lorenzo, Sperti, Elisa, Di Maio, Massimo, Ortega, Cinzia, Fenocchio, Elisabetta, Lombardi, Pasquale, Cagnazzo, Celeste, Depetris, Ilaria, Gelsomino, Fabio, Spallanzani, Andrea, Santini, Daniele, Silvestris, Nicola, Aprile, Giuseppe, Roviello, Giandomenico, Scartozzi, Mario, Cascinu, Stefano, Casadei‐Gardini, Andrea

“…Background An accurate risk‐stratification is key to optimize the benefit‐to‐risk ratio of palliative treatment in advanced biliary cancer. We aimed at…”
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Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial by Masi, Gianluca, Dr, Loupakis, Fotios, MD, Salvatore, Lisa, MD, Fornaro, Lorenzo, MD, Cremolini, Chiara, MD, Cupini, Samanta, MD, Ciarlo, Andrea, MD, Del Monte, Francesca, PhD, Cortesi, Enrico, MD, Amoroso, Domenico, MD, Granetto, Cristina, MD, Fontanini, Gabriella, Prof, Sensi, Elisa, MD, Lupi, Cristiana, MD, Andreuccetti, Michele, CTA, Falcone, Alfredo, MD

“…Summary Background The FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) regimen has been shown to be better than FOLFIRI (fluorouracil,…”
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Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist? by Vivaldi, Caterina, Catanese, Silvia, Massa, Valentina, Pecora, Irene, Salani, Francesca, Santi, Stefano, Lencioni, Monica, Vasile, Enrico, Falcone, Alfredo, Fornaro, Lorenzo

“…Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICI) have…”
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Molecular profile and its clinical impact of IDH1 mutated versus IDH1 wild type intrahepatic cholangiocarcinoma by Rimini, Margherita, Fabregat-Franco, Carles, Burgio, Valentina, Lonardi, Sara, Niger, Monica, Scartozzi, Mario, Rapposelli, Ilario Giovanni, Aprile, Giuseppe, Ratti, Francesca, Pedica, Federica, Verdaguer, Helena, Rizzato, Mario, Nichetti, Federico, Lai, Eleonora, Cappetta, Alessandro, Macarulla, Teresa, Fassan, Matteo, De Braud, Filippo, Pretta, Andrea, Simionato, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Fornaro, Lorenzo, Cascinu, Stefano, Casadei-Gardini, Andrea

“…IDH1 -mutated cholangiocarcinomas (CCAs) are an interesting group of neoplasia with particular behavior and therapeutic implications. The aim of the present…”
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Results of the observational prospective RealFLOT study by Giommoni, Elisa, Lavacchi, Daniele, Tirino, Giuseppe, Fornaro, Lorenzo, Iachetta, Francesco, Pozzo, Carmelo, Satolli, Maria Antonietta, Spallanzani, Andrea, Puzzoni, Marco, Stragliotto, Silvia, Sisani, Michele, Formica, Vincenzo, Giovanardi, Filippo, Strippoli, Antonia, Prisciandaro, Michele, Di Donato, Samantha, Pompella, Luca, Pecora, Irene, Romagnani, Alessandra, Fancelli, Sara, Brugia, Marco, Pillozzi, Serena, De Vita, Ferdinando, Antonuzzo, Lorenzo

“…Background Perioperative FLOT (5-fluorouracil, oxaliplatin and docetaxel) has recently become the gold standard treatment for fit patients with operable…”
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Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation by Fornaro, Lorenzo, Vivaldi, Caterina, Lin, Dong, Xue, Hui, Falcone, Alfredo, Wang, Yuzhuo, Crea, Francesco, Bootman, Martin D

“…T-type calcium channels (TTCCs) mediate calcium influx across the cell membrane. TTCCs regulate numerous physiological processes including cardiac pacemaking…”
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A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study by Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Raffaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, Mazzaferro, Vincenzo

“…Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1-3). The only potential curative treatment is surgical…”
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Comprehensive pharmacogenetic analysis of DPYD, UGT, CDA, and ABCB1 polymorphisms in pancreatic cancer patients receiving mFOLFIRINOX or gemcitabine plus nab-paclitaxel by Vivaldi, Caterina, Crucitta, Stefania, Catanese, Silvia, Cucchiara, Federico, Arrigoni, Elena, Pecora, Irene, Rofi, Eleonora, Fornaro, Lorenzo, Salani, Francesca, Massa, Valentina, Vasile, Enrico, Morganti, Riccardo, Danesi, Romano, Del Re, Marzia

“…Modified FOLFIRINOX (mFOLFIRINOX) and gemcitabine + nab-paclitaxel (GemNab) regimens represent a standard treatment in advanced pancreatic cancer (aPC). DPYD…”
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Correction to: A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY tract cancers (BTC) at high risk for recurrence: PURITY study by Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Rafaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, Mazzaferro, Vincenzo

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Concordance of microsatellite instability and mismatch repair status in paired biopsies and surgical specimens of resectable gastroesophageal adenocarcinoma: time for a call to action by Fornaro, Lorenzo, Lonardi, Sara, Catanese, Silvia, Nappo, Floriana, Pietrantonio, Filippo, Pellino, Antonio, Angerilli, Valentina, Signorini, Francesca, Salani, Francesca, Murgioni, Sabina, Neculaescu, Ioana Ancuta, Bruno, Rossella, Vivaldi, Caterina, Ricagno, Gianmarco, Masi, Gianluca, Bergamo, Francesca, Ugolini, Clara, Fassan, Matteo

“…Background Reliability of mismatch repair proteins and microsatellite instability assessment is essential in order to define treatment strategy and identify…”
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Impact of Aspirin on clinical outcome in advanced HCC patients receiving sorafenib and regorafenib by Casadei-Gardini, Andrea, Rovesti, Giulia, Dadduzio, Vincenzo, Vivaldi, Caterina, Lai, Eleonora, Lonardi, Sara, Fornaro, Lorenzo, Pretta, Andrea, Zagonel, Vittorina, Bernardini, Laura, Astara, Giorgio, D'Amico, Francesco E., Masi, Gianluca, Rimini, Margherita, Scartozzi, Mario, Cascinu, Stefano

“…The aim of our retrospective study is to evaluate the prognostic significance of aspirin in patients with advanced HCC treated with sorafenib. 304 patients…”
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Survival trends over 20 years in patients with advanced cholangiocarcinoma: Results from a national retrospective analysis of 922 cases in Italy by Casadei-Gardini, Andrea, Leone, Francesco, Brandi, Giovanni, Scartozzi, Mario, Silvestris, Nicola, Santini, Daniele, Faloppi, Luca, Aglietta, Massimo, Satolli, Maria Antonietta, Rizzo, Alessandro, Lonardi, Sara, Aprile, Giuseppe, Fornaro, Lorenzo

“…Cholangiocarcinoma is a rare group of tumors that involve the hepatic biliary tree. Prognosis for patients with cholangiocarcinoma remains dismal. Herein, we…”
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Evolving Landscape in Liver Transplantation for Hepatocellular Carcinoma: From Stage Migration to Immunotherapy Revolution by Cesario, Silvia, Genovesi, Virginia, Salani, Francesca, Vasile, Enrico, Fornaro, Lorenzo, Vivaldi, Caterina, Masi, Gianluca

“…Liver transplantation (LT) represents the primary curative option for HCC. Despite the extension of transplantation criteria and conversion with down-staging…”
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Sarcopenia in gastric cancer: when the loss costs too much by Ongaro, Elena, Buoro, Vanessa, Cinausero, Marika, Caccialanza, Riccardo, Turri, Annalisa, Fanotto, Valentina, Basile, Debora, Vitale, Maria Grazia, Ermacora, Paola, Cardellino, Giovanni Gerardo, Nicoletti, Laura, Fornaro, Lorenzo, Casadei-Gardini, Andrea, Aprile, Giuseppe

“…Sarcopenia is a complex syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Malignancy is a major determinant of…”
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The prognostic role of hemoglobin levels in patients undergoing concurrent chemo-radiation for anal cancer by Franco, Pierfrancesco, Montagnani, Francesco, Arcadipane, Francesca, Casadei, Chiara, Andrikou, Kalliopi, Martini, Stefania, Iorio, Giuseppe Carlo, Scartozzi, Mario, Mistrangelo, Massimiliano, Fornaro, Lorenzo, Cassoni, Paola, Cascinu, Stefano, Ricardi, Umberto, Casadei Gardini, Andrea

“…Concurrent chemo-radiation (CT-RT) is a standard therapy for squamous cell carcinoma of anal canal. Different clinical and biological factors may potentially…”
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Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review by Fornaro, Lorenzo, Caparello, Chiara, Vivaldi, Caterina, Rotella, Virginia, Musettini, Gianna, Falcone, Alfredo, Baldini, Editta, Masi, Gianluca

“…Despite advances in the management of patients with locally advanced,non-metastatic rectal adenocarcinoma(LARC),prognosis remains largely unsatisfactory due to…”
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