Search Results - "FORLENZA, O. V"

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders by Forlenza, O. V, De-Paula, V. J. R, Diniz, B. S. O

“…Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. More recently, based on…”
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Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder by Soeiro-de-Souza, M. G., Dias, V. V., Figueira, M. L., Forlenza, O. V., Gattaz, W. F., Zarate Jr, C. A., Machado-Vieira, R.

“…Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Objective: Bipolar disorder (BD) likely involves, at a molecular and cellular level, dysfunctions…”
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Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment by Pereira, F S, Yassuda, M S, Oliveira, A M, Forlenza, O V

“…Previous studies have reported an association between executive dysfunction and the ability to perform activities of daily living (ADL)s among older adults…”
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Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges by De-Paula, V. J., Forlenza, O. V.

“…The hyperphosphorylation of tau is a central mechanism in the pathogenesis of Alzheimer’s disease (AD). Lithium is a potent inhibitor of glycogen synthase…”
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The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease by Forlenza, O V, Schaeffer, E L, Gattaz, W F

“…Phospholipase A(2) (PLA(2)) is a key enzyme in cerebral phospholipid metabolism. Preliminary post-mortem studies have shown that PLA(2) activity is decreased…”
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Systemic Inflammation and Multimodal Biomarkers in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease by Magalhães, T. N. C., Weiler, M., Teixeira, C. V. L., Hayata, T., Moraes, A. S., Boldrini, V. O., dos Santos, L. M., de Campos, B. M., de Rezende, T. J. R., Joaquim, H. P. G., Talib, L. L., Forlenza, O. V., Cendes, F., Balthazar, Marcio L. F.

“…There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer’s disease (AD) is neuroinflammation, which plays…”
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Psychiatric manifestations of neurocysticercosis: a study of 38 patients from a neurology clinic in Brazil by Forlenza, O V, Filho, A H, Nobrega, J P, dos Ramos Machado, L, de Barros, N G, de Camargo, C H, da Silva, M F

“…OBJECTIVE: To determine the frequency and features of psychiatric morbidity in a cross section of 38 outpatients with neurocysticercosis. METHODS: Diagnosis of…”
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A Selective Association between Central and Peripheral Lithium Levels in Remitters in Bipolar Depression: A 3T-(7) Li Magnetic Resonance Spectroscopy Study by Machado-Vieira, R, Otaduy, M C, Zanetti, M V, De Sousa, R T, Dias, V V, Leite, C C, Forlenza, O V, Busatto, G F, Soares, J C, Gattaz, W F

“…The objective of this study was to evaluate brain lithium levels using (7) Li magnetic resonance spectroscopy after 6 weeks of lithium therapy in bipolar…”
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Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer’s disease patients by Talib, L. L., Hototian, S. R., Joaquim, H. P. G., Forlenza, O. V., Gattaz, W. F.

“…Reduced phospholipase A2 (PLA2) activity and increased phosphorylation of glycogen synthase kinase 3B (GSK3B) participate in the production of beta-amyloid…”
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Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3β inhibition and in neurons by FORLENZA, O. V, SPINK, J. M, DAYANANDAN, R, ANDERTON, B. H, OLESEN, O. F, LOVESTONE, S

“…Muscarinic agonists alter the metabolism of amyloid precursor protein, leading to an increase in alpha -secretase cleavage and a decreased production of…”
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A Selective Association between Central and Peripheral Lithium Levels in Remitters in Bipolar Depression: A 3T-7Li Magnetic Resonance Spectroscopy Study by Machado-Vieira, R., Otaduy, M. C., Zanetti, M. V., De Sousa, R. T., Dias, V. V., Leite, C. C., Forlenza, O. V., Busatto, G. F., Soares, J. C., Gattaz, W. F.

“…Objective The objective of this study was to evaluate brain lithium levels using 7Li magnetic resonance spectroscopy after 6 weeks of lithium therapy in…”
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Cellular prion protein binds laminin and mediates neuritogenesis by Graner, Edgard, Mercadante, Adriana F, Zanata, Silvio M, Forlenza, Orestes V, Cabral, Ana L.B, Veiga, Silvio S, Juliano, Maria A, Roesler, Rafael, Walz, Roger, Minetti, Alejandra, Izquierdo, Ivan, Martins, Vilma R, Brentani, Ricardo R

“…Laminin (LN) plays a major role in neuronal differentiation, migration and survival. Here, we show that the cellular prion protein (PrPc) is a saturable,…”
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The neuroprotective effect of dental pulp cells in models of Alzheimer’s and Parkinson’s disease by Apel, C., Forlenza, O. V., de Paula, V. J. R., Talib, L. L., Denecke, B., Eduardo, C. P., Gattaz, W. F.

“…Aim of the present study was to investigate the neuroprotective effect of dental pulp cells (DPCs) in in vitro models of Alzheimer and Parkinson disease…”
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Phospholipase A2 activity in rat embryonic brain and in primary cultures of cortical neurons by Forlenza, O V, Schaeffer, E L, Gattaz, W F

“…We investigated, with the aid of a radio-enzymatic method, the developmental changes in the activity of 85 kDa calcium-dependent cytosolic phospholipase A(2)…”
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Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons by Mendes, C T, Gattaz, W F, Schaeffer, E L, Forlenza, O V

“…In neurons, phospholipase A2 (PLA2) plays a central role in the regulation of membrane phospholipid metabolism. We have addressed the pharmacological…”
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Antidepressant efficacy of sertraline and imipramine for the treatment of major depression in elderly outpatients by Forlenza, O V, Stoppe Júnior, A, Hirata, E S, Ferreira, R C

“…Most double-blind studies of efficacy and tolerability of sertraline as compared to tricyclics in the treatment of late-life major depression have used…”
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Platelet phospholipase A(2) activity in Alzheimer's disease and mild cognitive impairment by Gattaz, W F, Forlenza, O V, Talib, L L, Barbosa, N R, Bottino, C M C

“…Phospholipase A(2) (PLA(2)) controls the metabolism of phospholipids in cell membranes. In the brain, PLA(2) influences the processing of the amyloid precursor…”
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Post-operative delirium is associated with poor cognitive outcome and dementia by Wacker, Priscilla, Nunes, Paula V, Cabrita, Henrique, Forlenza, Orestes V

“…The objective of the present study is to evaluate the association between the occurrence of delirium and the cognitive outcome in elderly subjects. Hospital…”
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PSYCHIATRIC MORBIDITY AMONG THE ELDERLY IN A PRIMARY CARE SETTING-REPORT FROM A SURVEY IN SÃO PAULO, BRAZIL by ALMEIDA, OSVALDO P., FORLENZA, ORESTES V., LIMA, NEREIDA K. COSTA, BIGLIANI, VALÉRIA, ARCURI, SILVIA M., GENTILE, MARIÂNGELA, FARIA, MARA M., LOURENÇO, CIBELE C., MACHADO DE OLIVEIRA, DILMA A.

“…Brazil has been experiencing a steady increase in the elderly population during the past few years, and as a result old age health‐related problems are…”
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Cerebrospinal fluid biomarkers in Alzheimer's disease: Diagnostic accuracy and prediction of dementia by Forlenza, Orestes V, Radanovic, Marcia, Talib, Leda L, Aprahamian, Ivan, Diniz, Breno S, Zetterberg, Henrik, Gattaz, Wagner F

“…Abstract Introduction Guidelines for the use of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) establish that each…”
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