Search Results - "FOLEY, Louise H"

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors by Foley, Louise H, Palermo, Robert, Dunten, Pete, Wang, Ping

“…The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human…”
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C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase by Pietranico, Sherrie L., Foley, Louise H., Huby, Nicholas, Yun, Weiya, Dunten, Pete, Vermeulen, John, Wang, Ping, Toth, Katherine, Ramsey, Gwendolyn, Gubler, Mary-Lou, Wertheimer, Stanley J.

“…Enzyme and cellular assay results for a number of new modifications on the C-8 aminobenzyl unit are reported. Pyrazole sulfonic acid amide analogs are shown to…”
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Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands by Crompton, Anne M., Foley, Louise H., Wood, Alexander, Roscoe, William, Stokoe, David, McCormick, Frank, Symons, Marc, Bollag, Gideon

“…Rho family GTPases play roles in cytoskeletal organization and cellular transformation. Tiam1 is a member of the Dbl family of guanine nucleotide exchange…”
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Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover…”
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X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines by FOLEY, Louise H, PING WANG, DUNTEN, Pete, RAMSEY, Gwendolyn, GUBLER, Mary-Lou, WERTHEIMER, Stanley J

“…The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The…”
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Biomimetic synthesis of dibromophakellin by Foley, Louise H, Buechi, George

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Investigation of the formation of methyl 2-cyano-2-[(trimethylsilyl)oxy]-4-oxopentanoate from methyl 2,4-dioxopentanoate. A clarification of the pathway for the reaction of trimethylsilyl cyanide with enolized .beta.-diketones by Foley, Louise H

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X‐ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin by Dunten, Pete, Kammlott, Ursula, Crowther, Robert, Levin, Wayne, Foley, Louise H., Wang, Ping, Palermo, Robert

“…A new class of matrix metalloproteinase (MMP) inhibitors has been identified by screening a collection of compounds against stromelysin. The inhibitors,…”
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The synthesis and biological testing of 2,2-dimethylpenam sulfone by Foley, L H, Weigele, M

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Ascorbic Acid Chemistry. A Novel LiAlH 4 Reduction Product and its Rearrangement by Foley, Louise H., Wang, Ping

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High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine by MIWA, M, EDA, H, URA, M, OUCHI, K. F, KEITH, D. D, FOLEY, L. H, ISHITSUKA, H

“…2'-Deoxy-2'-methylidenecytidine (DMDC) is a new 2'-deoxycytidine (dCyd) antimetabolite. The present study compared its antitumor activities with those of…”
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Ascorbic Acid Chemistry. A Novel LiAlH4 Reduction Product and its Rearrangement by Foley, Louise H., Wang, Ping

“…Reaction of 1 with LiAlH 4 affords the chiral monobenzyloxy diol, 5(S), 6-0-isopropylidene-4(R)-hydroxyl-2-benzyloxy-2-hexenol. Evidence is provided to support…”
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Inhibitors of Farnesyltransferase and Ras Processing Peptidase by Hall, C.C., Watkins, J.D., Ferguson, S.B., Foley, L.H., Georgopapadakou, N.H.

“…Four analogs of the carboxy terminus of unprocessed p21Ras processing protein were evaluated as inhibitors of the p21Ras farnesyltransferase and peptidase…”
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Covalent modification of the interleukin‐5 receptor by isothiazolones leads to inhibition of the binding of interleukin‐5 by Devos, René, Guisez, Yves, Plaetinck, Geert, Cornelis, Sigrid, Tavernier, Jan, Heyden, José, Foley, Louise H., Scheffler, Julie E.

“…Using a fusion protein of the human interleukin‐5‐receptor α chain (hILSRα) and the human IgG Cγ3 chain (hIL5Rα‐hγ3), we have developed a solid‐phase assay for…”
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