Search Results - "FOLEY, KEVIN P."

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction by Thevaranjan, Netusha, Puchta, Alicja, Schulz, Christian, Naidoo, Avee, Szamosi, J.C., Verschoor, Chris P., Loukov, Dessi, Schenck, Louis P., Jury, Jennifer, Foley, Kevin P., Schertzer, Jonathan D., Larché, Maggie J., Davidson, Donald J., Verdú, Elena F., Surette, Michael G., Bowdish, Dawn M.E.

“…Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated. We…”
Get full text

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation by Klip, Amira, Sun, Yi, Chiu, Tim Ting, Foley, Kevin P

“…Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by insulin-elicited signals that impart mobilization of GLUT4 glucose…”
Get more information

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4 by Cavallari, Joseph F., Fullerton, Morgan D., Duggan, Brittany M., Foley, Kevin P., Denou, Emmanuel, Smith, Brennan K., Desjardins, Eric M., Henriksbo, Brandyn D., Kim, Kalvin J., Tuinema, Brian R., Stearns, Jennifer C., Prescott, David, Rosenstiel, Philip, Coombes, Brian K., Steinberg, Gregory R., Schertzer, Jonathan D.

“…Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics, prebiotics, or probiotics can be limited by specificity…”
Get full text

RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice by Duggan, Brittany M, Cavallari, Joseph F, Foley, Kevin P, Barra, Nicole G, Schertzer, Jonathan D

“…Abstract Tyrosine kinase inhibitors (TKIs) used in cancer are also being investigated in diabetes. TKIs can improve blood glucose control in diabetic cancer…”
Get full text

The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice by McBride, Marin Jane, Foley, Kevin P, D'Souza, Donna M, Li, Yujin E, Lau, Trevor C, Hawke, Thomas J, Schertzer, Jonathan D

“…The mechanisms underpinning decreased skeletal muscle strength and slowing of movement during aging are ill-defined. "Inflammaging," increased inflammation…”
Get more information

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance by Foley, Kevin P., Zlitni, Soumaya, Denou, Emmanuel, Duggan, Brittany M., Chan, Rebecca W., Stearns, Jennifer C., Schertzer, Jonathan D.

“…The intestinal microbiota and insulin sensitivity are rapidly altered after ingestion of obesogenic diets. We find that changes in the composition of the fecal…”
Get full text

Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy by Ying, Weiwen, Du, Zhenjian, Sun, Lijun, Foley, Kevin P, Proia, David A, Blackman, Ronald K, Zhou, Dan, Inoue, Takayo, Tatsuta, Noriaki, Sang, Jim, Ye, Shuxia, Acquaviva, Jamie, Ogawa, Luisa Shin, Wada, Yumiko, Barsoum, James, Koya, Keizo

“…Targeted inhibition of the molecular chaperone Hsp90 results in the simultaneous blockade of multiple oncogenic signaling pathways and has, thus, emerged as an…”
Get full text

Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance by Henriksbo, Brandyn D, Lau, Trevor C, Cavallari, Joseph F, Denou, Emmanuel, Chi, Wendy, Lally, James S, Crane, Justin D, Duggan, Brittany M, Foley, Kevin P, Fullerton, Morgan D, Tarnopolsky, Mark A, Steinberg, Gregory R, Schertzer, Jonathan D

“…Statins reduce lipid levels and are widely prescribed. Statins have been associated with an increased incidence of type 2 diabetes, but the mechanisms are…”
Get full text

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses by Yu, Jong W, Hoffman, Sandy, Beal, Allison M, Dykon, Angela, Ringenberg, Michael A, Hughes, Anna C, Dare, Lauren, Anderson, Amber D, Finger, Joshua, Kasparcova, Viera, Rickard, David, Berger, Scott B, Ramanjulu, Joshi, Emery, John G, Gough, Peter J, Bertin, John, Foley, Kevin P

“…CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this…”
Get full text

Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1 by Chi, Wendy, Dao, Dyda, Lau, Trevor C, Henriksbo, Brandyn D, Cavallari, Joseph F, Foley, Kevin P, Schertzer, Jonathan D

“…Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to…”
Get full text

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction by Thevaranjan, Netusha, Puchta, Alicja, Schulz, Christian, Naidoo, Avee, Szamosi, J.C., Verschoor, Chris P., Loukov, Dessi, Schenck, Louis P., Jury, Jennifer, Foley, Kevin P., Schertzer, Jonathan D., Larché, Maggie J., Davidson, Donald J., Verdú, Elena F., Surette, Michael G., Bowdish, Dawn M.E.

Get full text

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells by Sun, Yi, Chiu, Tim T, Foley, Kevin P, Bilan, Philip J, Klip, Amira

“…Rab-GTPases are important molecular switches regulating intracellular vesicle traffic, and we recently showed that Rab8A and Rab13 are activated by insulin in…”
Get full text

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance by Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff‐Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D

“…Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of…”
Get full text

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non―Small Cell Lung Cancer by SHIMAMURA, Takeshi, PERERA, Samanthi A, SINHA, Papiya, CAREY, Christopher D, BORGMAN, Christa L, JIMENEZ, John-Paul, MEYERSON, Matthew, WEIWEN YING, BARSOUM, James, WONG, Kwok-Kin, SHAPIRO, Geoffrey I, FOLEY, Kevin P, JIM SANG, RODIG, Scott J, INOUE, Takayo, LIANG CHEN, DANAN LI, CARRETERO, Julian, LI, Yu-Chen

“…We describe the anticancer activity of ganetespib, a novel non-geldanamycin heat shock protein 90 (HSP90) inhibitor, in non-small cell lung cancer (NSCLC)…”
Get full text

Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia by Duggan, Brittany M., Foley, Kevin P., Henriksbo, Brandyn D., Cavallari, Joseph F., Tamrakar, Akhilesh K., Schertzer, Jonathan D.

“…Inflammation underpins aspects of insulin resistance and dysglycemia. Microbiota-derived cell wall components such as muropeptides or endotoxin can trigger…”
Get full text

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance by Tamrakar, Akhilesh K, Schertzer, Jonathan D, Chiu, Tim T, Foley, Kevin P, Bilan, Philip J, Philpott, Dana J, Klip, Amira

“…Insulin resistance is associated with chronic low-grade inflammation in vivo, largely mediated by activated innate immune cells. Cytokines and pathogen-derived…”
Get full text

Gut microbiota impairs insulin clearance in obese mice by Foley, Kevin P., Zlitni, Soumaya, Duggan, Brittany M., Barra, Nicole G., Anhê, Fernando F., Cavallari, Joseph F., Henriksbo, Brandyn D., Chen, Cassandra Y., Huang, Michael, Lau, Trevor C., Plante, Roxanne, Schwab, Michael, Marette, André, Schertzer, Jonathan D.

“…Hyperinsulinemia can be both a cause and consequence of obesity and insulin resistance. Hyperinsulinemia can result from increased insulin secretion and/or…”
Get full text

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles by Boguslavsky, Shlomit, Chiu, Tim, Foley, Kevin P, Osorio-Fuentealba, Cesar, Antonescu, Costin N, Bayer, K Ulrich, Bilan, Philip J, Klip, Amira

“…GLUT4-containing vesicles cycle between the plasma membrane and intracellular compartments. Insulin promotes GLUT4 exocytosis by regulating GLUT4 vesicle…”
Get full text

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage by Klei, Linda R., Hu, Dong, Panek, Robert, Alfano, Danielle N., Bridwell, Rachel E., Bailey, Kelly M., Oravecz-Wilson, Katherine I., Concel, Vincent J., Hess, Emily M., Van Beek, Matthew, Delekta, Phillip C., Gu, Shufang, Watkins, Simon C., Ting, Adrian T., Gough, Peter J., Foley, Kevin P., Bertin, John, McAllister-Lucas, Linda M., Lucas, Peter C.

“…Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment,…”
Get full text

The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors by Lin, Tzu-Yin, Bear, Misty, Du, Zhenjian, Foley, Kevin P, Ying, Weiwen, Barsoum, James, London, Cheryl

“…Objective Mutations of the receptor tyrosine kinase Kit occur in several human and canine cancers. While Kit inhibitors have activity in the clinical setting,…”
Get full text