Search Results - "FOKKENS, Wytske J"

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells by Mjösberg, Jenny, Bernink, Jochem, Golebski, Korneliusz, Karrich, Julien J., Peters, Charlotte P., Blom, Bianca, te Velde, Anje A., Fokkens, Wytske J., van Drunen, Cornelis M., Spits, Hergen

“…Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue…”
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Highlights in the advances of chronic rhinosinusitis by Xu, Xinni, Reitsma, Sietze, Wang, De Yun, Fokkens, Wytske J.

“…Chronic rhinosinusitis (CRS) is a complex upper airway inflammatory disease with a broad spectrum of clinical variants. As our understanding of the disease…”
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Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma by Breiteneder, Heimo, Peng, Ya‐Qi, Agache, Ioana, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Traidl‐Hoffmann, Claudia, Nadeau, Kari, O'Hehir, Robyn E., O'Mahony, Liam, Pfaar, Oliver, Torres, Maria J., Wang, De‐Yun, Zhang, Luo, Akdis, Cezmi A.

“…Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the…”
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Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 by Mjösberg, Jenny M, Trifari, Sara, Crellin, Natasha K, Peters, Charlotte P, van Drunen, Cornelis M, Piet, Berber, Fokkens, Wytske J, Cupedo, Tom, Spits, Hergen

“…Mice have lineage-negative IL-7Rα + (innate lymphoid) cells that contribute to type 2 immunity. Spits and colleagues identify a similar CRTH2 + CD161 +…”
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Local allergic rhinitis: Concept, pathophysiology, and management by Rondón, Carmen, MD, PhD, Campo, Paloma, MD, PhD, Togias, Alkis, MD, PhD, Fokkens, Wytske J., MD, PhD, Durham, Stephen R., MD, PhD, Powe, Desmond G., PhD, Mullol, Joaquim, MD, PhD, Blanca, Miguel, MD, PhD

“…Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy characterized by local production of specific IgE (sIgE)…”
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Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis by Bergmann, Karl-Christian, MD, Demoly, Pascal, MD, PhD, Worm, Margitta, MD, Fokkens, Wytske J., MD, PhD, Carrillo, Teresa, MD, PhD, Tabar, Ana I., MD, PhD, Nguyen, Hélène, PharmD, Montagut, Armelle, Zeldin, Robert K., MD

“…Background Preliminary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in adults with allergic rhinitis. Objectives…”
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Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care by Breiteneder, Heimo, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J., Traidl‐Hoffmann, Claudia, Nadeau, Kari, O’Hehir, Robyn E., O’Mahony, Liam, Pfaar, Oliver, Torres, Maria J., Wang, De Yun, Zhang, Luo, Akdis, Cezmi A.

“…The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease…”
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IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation by Golebski, Korneliusz, Ros, Xavier R., Nagasawa, Maho, van Tol, Sophie, Heesters, Balthasar A., Aglmous, Hajar, Kradolfer, Chantal M. A., Shikhagaie, Medya M., Seys, Sven, Hellings, P. W., van Drunen, Cornelis M., Fokkens, Wytske J., Spits, Hergen, Bal, Suzanne M.

“…Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue…”
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Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients by Fong, Stephanie A, Drilling, Amanda, Morales, Sandra, Cornet, Marjolein E, Woodworth, Bradford A, Fokkens, Wytske J, Psaltis, Alkis J, Vreugde, Sarah, Wormald, Peter-John

“…infections are prevalent amongst chronic rhinosinusitis (CRS) sufferers. Many strains form biofilms, leading to treatment failure. Lytic bacteriophages…”
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Endotyping of non-allergic, allergic and mixed rhinitis patients using a broad panel of biomarkers in nasal secretions by Segboer, Christine L, Fokkens, Wytske J, Terreehorst, Ingrid, van Drunen, Cornelis M

“…Endotyping chronic rhinitis has proven hardest for the subgroup of non-allergic rhinitis (NAR) patients. While IgE-related inflammation is typical for allergic…”
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European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis by Gevaert, Philippe, De Craemer, Jarno, Bachert, Claus, Blauwblomme, Manon, Chaker, Adam, Cingi, Cemal, Hellings, Peter W., Hopkins, Claire, Hox, Valérie, Fokkens, Wytske J., Klimek, Ludger, Lund, Valerie, Mösges, Ralph, Mullol, Joaquim, Pfaar, Oliver, Scadding, Glenis, Tomazic, Peter Valentin, Van Zele, Thibaut, Vlaminck, Stephan, Wagenmann, Martin, Toppila‐Salmi, Sanna, Alobid, Isam

“…Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also for monitoring the response to therapy…”
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Endotype‐driven treatment in chronic upper airway diseases by De Greve, Glynnis, Hellings, Peter W., Fokkens, Wytske J., Pugin, Benoit, Steelant, Brecht, Seys, Sven F.

“…Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect…”
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Prevalence and impact of nasal hyperreactivity in chronic rhinosinusitis by Doulaptsi, Maria, Steelant, Brecht, Prokopakis, Emmanuel, Ierodiakonou, Despo, Tsinaslanidou, Zinovia, Cools, Leen, Pugin, Benoit, Milioni, Athanasia, Van Gerven, Laura, Fokkens, Wytske J., Constantinidis, Jiannis, Hellings, Peter W.

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Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases by van der Ploeg, Esmee K, Golebski, Korneliusz, van Nimwegen, Menno, Fergusson, Joannah R, Heesters, Balthasar A, Martinez-Gonzalez, Itziar, Kradolfer, Chantal M A, van Tol, Sophie, Scicluna, Brendon P, de Bruijn, Marjolein J W, de Boer, Geertje M, Tramper-Stranders, Gerdien A, Braunstahl, Gert-Jan, van IJcken, Wilfred F J, Nagtegaal, A Paul, van Drunen, Cornelis M, Fokkens, Wytske J, Huylebroeck, Danny, Spits, Hergen, Hendriks, Rudi W, Stadhouders, Ralph, Bal, Suzanne M

“…Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been implicated in various immune disorders. In the mouse, circulatory…”
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Challenges in the Management of Inverted Papilloma: A Review of 72 Revision Cases by Adriaensen, Gwijde F. J. P. M., Lim, Keng-Hua, Georgalas, Christos, Reinartz, Susanne M., Fokkens, Wytske J.

“…Objectives/Hypothesis We report on the treatment outcome of endoscopically managed sinonasal inverted papilloma, focusing on revision cases. Our aim was to…”
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Specific Induction of TSLP by the Viral RNA Analogue Poly(I:C) in Primary Epithelial Cells Derived from Nasal Polyps by Golebski, Korneliusz, van Tongeren, Joost, van Egmond, Danielle, de Groot, Esther J, Fokkens, Wytske J, van Drunen, Cornelis M

“…Chronic rhinosinusitis with nasal polyposis is an inflammatory disease that, although not directly linked to allergy, often displays a Th2-skewed inflammation…”
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ICON: chronic rhinosinusitis by Bachert, Claus, Pawankar, Ruby, Zhang, Luo, Bunnag, Chaweewan, Fokkens, Wytske J, Hamilos, Daniel L, Jirapongsananuruk, Orathai, Kern, Robert, Meltzer, Eli O, Mullol, Joaquim, Naclerio, Robert, Pilan, Renata, Rhee, Chae-Seo, Suzaki, Harumi, Voegels, Richard, Blaiss, Michael

“…Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its…”
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The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression by Wagener, Ariane H, Zwinderman, Aeilko H, Luiten, Silvia, Fokkens, Wytske J, Bel, Elisabeth H, Sterk, Peter J, van Drunen, Cornelis M

“…The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these…”
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Defining appropriateness criteria for endoscopic sinus surgery during management of uncomplicated adult chronic rhinosinusitis: a RAND/UCLA appropriateness study by Rudmik, Luke, Soler, Zachary M., Hopkins, Claire, Schlosser, Rodney J., Peters, Anju, White, Andrew A., Orlandi, Richard R., Fokkens, Wytske J., Douglas, Richard, Smith, Timothy L.

“…Background Appropriate indications for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical…”
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How to be a good reviewer: A step‐by‐step guide for approaching peer review of a scientific manuscript by Sedaghat, Ahmad R., Bernal‐Sprekelsen, Manuel, Fokkens, Wytske J., Smith, Timothy L., Stewart, Michael G., Johnson, Romaine F.

“…Objectives The peer review process is critical to maintaining quality, reliability, novelty, and innovation in the scientific literature. However, the teaching…”
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