Search Results - "FODSTAD, Ø"

Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells by Song, B, Wang, Y, Xi, Y, Kudo, K, Bruheim, S, Botchkina, G I, Gavin, E, Wan, Y, Formentini, A, Kornmann, M, Fodstad, O, Ju, J

“…In this study, high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in…”
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Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis by Srivastava, S K, Bhardwaj, A, Arora, S, Tyagi, N, Singh, A P, Carter, J E, Scammell, J G, Fodstad, Ø, Singh, S

“…Background: FKBP51 is overexpressed in melanoma and impacts tumour cell properties. However, its comprehensive role in melanoma pathogenesis and underlying…”
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Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c by Nygren, M K, Tekle, C, Ingebrigtsen, V A, Mäkelä, R, Krohn, M, Aure, M R, Nunes-Xavier, C E, Perälä, M, Tramm, T, Alsner, J, Overgaard, J, Nesland, J M, Borgen, E, Børresen-Dale, A-L, Fodstad, Ø, Sahlberg, K K, Leivonen, S-K

“…Background: B7-H3, an immunoregulatory protein, is overexpressed in several cancers and is often associated with metastasis and poor prognosis. Here, our aim…”
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Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth by Zhao, Y H, Zhou, M, Liu, H, Ding, Y, Khong, H T, Yu, D, Fodstad, O, Tan, M

“…ErbB2 has been shown to activate signaling molecules that may regulate glucose metabolism. However, there is no evidence reported to directly link ErbB2 to…”
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Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin by Andersson, Y, Engebraaten, O, Juell, S, Aamdal, S, Brunsvig, P, Fodstad, Ø, Dueland, S

“…Background: A phase I trial was performed to determine the maximum tolerated dose (MTD), safety, pharmacokinetics and immunogenicity of the anti-EpCAM…”
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Detection and Clinical Importance of Micrometastatic Disease by Pantel, Klaus, Cote, Richard J., Fodstad, Øystein

“…Metastatic relapse in patients with solid tumors is caused by systemic preoperative or perioperative dissemination of tumor cells. The presence of individual…”
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Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo by Andersson, Y, Engebraaten, O, Fodstad, Ø

“…Background: The clinical use of immunotoxins (ITs) has been hampered by hepatotoxicity, and the induction of a strong human-anti-IT response. The human-anti-IT…”
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Clinically proven markers of metastasis predict metastatic spread of human melanoma cells engrafted in scid mice by THIES, A, MAUER, S, FODSTAD, O, SCHUMACHER, U

“…Metastasis formation is a complex process and as such can only be modelled in vivo. As markers indicating metastatic spread in syngenic mouse models differ…”
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Disseminated tumour cells as a prognostic biomarker in colorectal cancer by Flatmark, K, Borgen, E, Nesland, J M, Rasmussen, H, Johannessen, H-O, Bukholm, I, Rosales, R, Hårklau, L, Jacobsen, H J, Sandstad, B, Boye, K, Fodstad, Ø

“…Background: The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively…”
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Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase‐polymerase chain reaction assays used to detect micrometastatic tumor cells by Ruud, Paal, Fodstad, Øystein, Hovig, Eivind

“…In many recent publications, it has been claimed that reverse transcriptase‐polymerase chain reaction (RT‐PCR) assays involving genes with tissue‐restricted…”
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Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16) by Rappa, G, Shyam, K, Lorico, A, Fodstad, O, Sartorelli, A C

“…We have previously reported that the antibiotic novobiocin enhanced the toxicity of the anticancer agent etoposide (VP-16) to several drug-sensitive and…”
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76P B7-H3 immune checkpoint protein expression is associated with immune exhaustion, overall survival and metastasis in clear cell renal cell carcinoma by Nunes-Xavier, C.E., Emaldi, M., Øyjord, T., Larrinaga, G., Errarte, P., Angulo, J.C., Llarena, R., Mælandsmo, G.M., Fodstad, Ø., Pulido, R., López, J.I.

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Clinical significance of disseminated tumour cells in non-small cell lung cancer by Kongsgaard, A, Borgen, E, Mælandsmo, G M, Flatmark, K, Le, H, Josefsen, D, Solvoll, I, Schirmer, C B, Helland, Å, Jørgensen, L, Brustugun, O T, Fodstad, Ø, Boye, K

“…Background: Early-stage non-small cell lung cancer (NSCLC) patients have a high risk of disease relapse despite curatively intended surgical resection, and the…”
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Preclinical phase II studies in human tumor xenografts: a European multicenter follow-up study by Langdon, S P, Hendriks, H R, Braakhuis, B J, Pratesi, G, Berger, D P, Fodstad, O, Fiebig, H H, Boven, E

“…The EORTC New Drug Development Office has initiated a multicenter collaborative program to evaluate the use of human tumor xenografts to predict phase II…”
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Photochemical internalization : A novel technology for delivery of macromolecules into cytosol by BERG, K, SELBO, P. K, RODAL, G. H, RODAL, S. K, HØGSET, A, PRASMICKAITE, L, TJELLE, T. E, SANDVIG, K, MOAN, J, GAUDERNACK, G, FODSTAD, Ø, KJØLSRUD, S, ANHOLT, H

“…The therapeutic usefulness of macromolecules, such as in gene therapy, is often limited by an inefficient transfer of the macromolecule to the cytosol and a…”
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Phase II preclinical drug screening in human tumor xenografts : a first european multicenter collaborative study by BOVEN, E, WINOGRAD, B, BERGER, D. P, DUMONT, M. P, BRAAKHUIS, B. J. M, FODSTAD, Ø, LANGDON, S, FIEBIG, H. H

“…In a European joint project carried out in 6 laboratories a disease-oriented program was set up consisting of a panel of 7 tumor types, each represented by 4…”
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Immunoregulatory Protein B7-H3 Promotes Growth and Decreases Tumor Cell Sensitivity to Anti-Cancer Agents by Nunes-Xavier, C., Flem-Karlsen, K., Tekle, C., Fodstad, Ø

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Primary neural stem progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma by Lorico, A, Mercapide, J, Soloduschko, V, Alexeyev, M, Fodstad, O, Rappa, G

“…Despite recent technical improvements in surgical excision techniques and adjuvant radio- and chemotherapy, the clinical outcome of patients with grade IV…”
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Targeted therapy with immunotoxins in a nude rat model for leptomeningeal growth of human small cell lung cancer by MYKLEBUST, A. T, GODAL, A, FODSTAD, Ø

“…Metastasis to the central nervous system in patients with small cell lung cancer is not uncommon, and a fraction of the cases have leptomeningeal disease for…”
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Site‐specific experimental metastasis patterns of two human breast cancer cell lines in nude rats by Engebraaten, Olav, Fodstad, Øystein

“…Animal models for breast cancer metastasis are valuable tools for studying mechanisms of metastasis and for pre‐clinical testing of anti‐metastatic therapy…”
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