Search Results - "FLYNN, Sean T"

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists by JOHNSON, Dale J, FORBES, Ian T, MURKITT, Graham S, LUCAS, Adam J, MOOKHERJEE, Claudette R, WATSON, Jeannette M, GARTLON, Jane E, BRADFORD, Andrea M, BROWN, Fiona, WATSON, Steve P, GARZYA, Vincenzo, STEVENSON, Graeme I, WALKER, Graham R, MUDHAR, Harminder S, FLYNN, Sean T, WYMAN, Paul A, SMITH, Paul W

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists…”
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Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands—Part II by Ward, Simon E., Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M., Wyman, Paul A.

“…A series of 5-(piperidinylethyloxy)quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously…”
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Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part II by Ward, Simon E, Eddershaw, Peter, Flynn, Sean T, Gordon, Laurie, Lovell, Peter J, Moore, Susan H, Scott, Claire M, Smith, Paul W, Thewlis, Kevin M, Wyman, Paul A

“…A series of 5-(piperidinylethyloxy)quinoline 5-HT(1) receptor ligands have been studied by elaboration of the series of dual 5-HT(1)-SSRIs reported previously…”
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Identification of a potent and selective 5-HT1B receptor antagonist by WYMAN, Paul A, MARSHALL, Howard R, FLYNN, Sean T, KING, Ron J, THOMPSON, Mervyn, SMITH, Paul W, HADLEY, Michael S, PRICE, Gary W, SCOTT, Claire M, DAWSON, Lee A

“…An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a…”
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogs of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase by Coates, William J, Connolly, Brendan, Dhanak, Dashyant, Flynn, Sean T, Worby, Angela

“…The synthesis and phosphodiesterase (PDE) inhibitory profile of a series of imidazopyridines, including sulmazole and isomazole, on separated PDE isoenzymes…”
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M 1 agonists by Johnson, Dale J., Forbes, Ian T., Watson, Steve P., Garzya, Vincenzo, Stevenson, Graeme I., Walker, Graham R., Mudhar, Harminder S., Flynn, Sean T., Wyman, Paul A., Smith, Paul W., Murkitt, Graham S., Lucas, Adam J., Mookherjee, Claudette R., Watson, Jeannette M., Gartlon, Jane E., Bradford, Andrea M., Brown, Fiona

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M 1…”
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Studies on a series of potent, orally bioavailable, 5-HT 1 receptor ligands—Part II by Ward, Simon E., Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M., Wyman, Paul A.

“…SAR studies on a series of substituted phenyl piperazines and piperidines are described. Several examples are disclosed as potent 5-HT 1 receptor ligands and…”
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Studies on a series of potent, orally bioavailable, 5.HT1receptor ligands-Part II by WARD, Simon E, EDDERSHAW, Peter, FLYNN, Sean T, GORDON, Laurie, LOVELL, Peter J, MOORE, Susan H, SCOTT, Claire M, SMITH, Paul W, THEWLIS, Kevin M, WYMAN, Paul A

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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M sub(1) agonists by Johnson, Dale J, bes, Ian T, Watson, Steve P, Garzya, Vincenzo, Stevenson, Graeme I, Walker, Graham R, Mudhar, Harminder S, Flynn, Sean T, Wyman, Paul A, Smith, Paul W, Murkitt, Graham S, Lucas, Adam J, Mookherjee, Claudette R, Watson, Jeannette M, Gartlon, Jane E, Bradford, Andrea M, Brown, Fiona

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M sub(1)…”
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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core by Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher

“…Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model. The discovery of a series of novel and orally…”
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Identification of a potent and selective 5-HT 1B receptor antagonist by Wyman, Paul A., Marshall, Howard R., Flynn, Sean T., King, Ron J., Thompson, Mervyn, Smith, Paul W., Hadley, Michael S., Price, Gary W., Scott, Claire M., Dawson, Lee A.

“…Introduction of cis-2,6-dimethyl substitution onto the piperazine ring of a mixed 5-HT 1ABD receptor antagonist offers a combination of both excellent…”
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2-(alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 by BOYD, H. F, FLYNN, S. T, SMITH, S. A, STANSFIELD, I. G, TEW, D. G, THEOBALD, C. J, HICKEY, D. M. B, IFE, R. J, JONES, M, LEACH, C. A, MACPHEE, C. H, MILLINER, K. J, RAWLINGS, D. A, SLINGSBY, B. P

“…Starting from two weakly active hits from high throughput screening, a novel series of 2-(alkylthio)-pyrimidin-4-ones with high potency and selectivity for…”
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2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A 2 by Boyd, Helen F., Flynn, Sean T., Hickey, Deirdre M.B., Ife, Robert J., Jones, Martin, Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Rawlings, D.Anthony, Slingsby, Brian P., Smith, Stephen A., Stansfield, Ian G., Tew, David G., Theobald, Colin J.

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N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A 2 by Boyd, Helen F., Fell, Stephen C.M., Flynn, Sean T., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Porter, Rod A., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Tew, David G., Theobald, Colin J., Whittaker, Caroline M.

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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