Search Results - "FLYNN, Gordon L"

Absorption of polyethylene glycols 600 through 2000 : the molecular weight dependence of gastrointestinal and nasal absorption by DONOVAN, M. D, FLYNN, G. L, AMIDON, G. L

“…Polyethylene glycols (PEGs) 600, 1000, and 2000 were used to study the molecular weight permeability dependence in the rat nasal and gastrointestinal mucosa…”
Get full text

Release of Hydrocortisone from a Cream Matrix: Dependency of Release on Suspension Concentration and Measurement of Solubility and Diffusivity by Pillai, Radhakrishnan, Shah, Vinod, Abriola, Linda, Caetano, Pedro, Flynn, Gordon L.

“…The principal object of the present research was to investigate the sensitivity of drug release from a semisolid system to the manner of its preparation and to…”
Get full text

Penetration of minoxidil from ethanol/propylene glycol solutions: effect of application volume and occlusion by Tata, S, Flynn, G L, Weiner, N D

“…We have previously established that the relative concentrations of propylene glycol and ethanol as a binary solvent system have a significant effect on the…”
Get more information

Percutaneous absorption and dermal delivery of cyclosporin A by Choi, H K, Flynn, G L, Amidon, G L

“…The present study deals with attempts to deliver cyclosporin A into the deeper skin and some of the fundamental reasons why this proves so difficult. Because…”
Get more information

Transdermal Prodrug Concepts : Permeation of Buprenorphine and Its Alkyl Esters through Hairless Mouse Skin and Influence of Vehicles by IMOTO, Hirofumi, ZHOU, ZiQi, STINCHCOMB, Audra L., FLYNN, Gordon L.

“…In vitro skin permeation of buprenorphine (BUP) and three of its alkyl ester prodrugs was evaluated using hairless mouse skin. The three esters selected were…”
Get full text

Systemic uptake and clearance of chloroform by hairless rats following dermal exposure. I. Brief exposure to aqueous solutions by Islam, M S, Zhao, L, Zhou, J, Dong, L, McDougal, J N, Flynn, G L

“…The systemic uptake of chloroform from dilute aqueous solutions into live hairless rats under conditions simulating dermal environmental exposure was studied…”
Get more information

Physicochemical characterization of the human nail: permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum by Walters, K A, Flynn, G L, Marvel, J R

“…In order to develop a basic concept of the permeability of the human nail plate and thus create a better understanding of the toxic potentials and therapeutic…”
Get more information

Physicochemical characterization of the human nail: solvent effects on the permeation of homologous alcohols by Walters, K A, Flynn, G L, Marvel, J R

“…To assess how vehicles might influence permeation through human nail, the diffusion of homologous alcohols (methanol to decanol) administered as neat liquids…”
Get more information

Hydration and Percutaneous Absorption: I. Influence of Hydration on Alkanol Permeation Through Hairless Mouse Skin by Behl, Charanjit R., Flynn, Gordon L., Kurihara, Tamie, Harper, Nancy, Smith, Ward, Higuchi, William I., Ho, Norman F.H., Pierson, Carl L.

“…A method to study the influence of hydration on skin permeability where the skin is immersed in saline for up to 30hr and under circumstances where a steady…”
Get full text

Permeation of mouse skin and silicone rubber membranes by phenols: relationship to in vitro partitioning by Jetzer, W E, Huq, A S, Ho, N F, Flynn, G L, Duraiswamy, N, Condie, Jr, L

“…A discrepancy has been noted in the relationship between the relative skin permeabilities of phenols and their lipophilicities as expressed in commonly used…”
Get more information

Penetration of the human nail plate: the effects of vehicle pH on the permeation of miconazole by Walters, K A, Flynn, G L, Marvel, J R

“…In order to assess the relative permeability of the nail plate to ionized and unionized drugs the permeation of miconazole at varying pH has been followed as a…”
Get more information

Bioequivalence of topical dermatological dosage forms : Methods of evaluation of bioequivalence by SHAH, V. P, FLYNN, G. L, MARTY, J.-P, PERSHING, L. K, SCHAEFER, H, SEQUEIRA, J. A, SHRIVASTAVA, S. P, WILKIN, J, WILLIAMS, R. L, YACOBI, A, MAIBACH, H. I, BON, C, FLEISCHER, N. M, FRANZ, T. J, KAPLAN, S. A, KAWAMOTO, J, LESKO, L. J

Get full text

Physiocochemical Characterization of the Human Nail: I. Pressure Sealed Apparatus for Measuring Nail Plate Permeabilities by Walters, Kenneth A., Flynn, Gordon L., Marvel, John R.

“…Diffusion characteristics of the nail plate are necessary in providing the baselines for rational topical management of nail infections. In order to develop…”
Get full text

Transfollicular drug delivery by LAUER, A. C, LIEB, L. M, RAMACHANDRAN, C, FLYNN, G. L, WEINER, N. D

“…The hair follicle, hair shaft, and sebaceous gland collectively form what is recognized as the pilosebaceous unit. This complex, three-dimensional structure…”
Get full text

Assessment of value and applications of in vitro testing of topical dermatological drug products by FLYNN, G. L, SHAH, V. P, SWARBRICK, J, WANG, J. C. T, YACOBI, A, ZATZ, J. L, TENJARLA, S. N, CORBO, M, DEMAGISTRIS, D, FELDMAN, T. G, FRANZ, T. J, MIRAN, D. R, PEARCE, D. M, SEQUEIRA, J. A

“…The FDA recently issued a guidance covering practices of scaleup and post approval changes with semisolids (SUPAC-SS). This guidance outlines the steps that…”
Get full text

Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate III: Permeability differences of vidarabine and n-pentanol in components of hairless mouse skin by Yu, C D, Higuchi, W I, Ho, N F, Fox, J L, Flynn, G L

“…The permeation behavior of 3H-vidarabine (3H-9-beta-D-ara-binofuranosyladenine) and 14C-n-pentanol through different strata of hairless mouse skin was studied…”
Get more information

Physicochemical characterization and solubility analysis of thalidomide and its N-alkyl analogs by GOOSEN, Colleen, LAING, Timothy J, PLESSIS, Jeanetta Du, GOOSEN, Theunis C, FLYNN, Gordon L

“…The present study was primarily aimed at exploring the feasibility of improving percutaneous delivery via chemical manipulation of the thalidomide molecule to…”
Get full text

Uptake of chloroform by skin on brief exposures to the neat liquid by Islam, M S, Zhao, L, McDougal, J N, Flynn, G L

“…The uptake of chloroform into hairless rat's stratum corneum after application of the neat solvent directly to the skin has been studied. Tape stripping was…”
Get more information

Controlled transdermal delivery of fentanyl: characterizations of pressure-sensitive adhesives for matrix patch design by Roy, S D, Gutierrez, M, Flynn, G L, Cleary, G W

“…Transdermal delivery of fentanyl from various adhesive matrix formulations to achieve a steady-state skin flux was investigated. For this purpose, various…”
Get more information

Reversible Formation and Hydrolysis of Phthaloyl and Succinyl Monophosphates in Aqueous Solution by Higuchi, Takeru, Flynn, Gordon L, Shah, Ashok C

Get full text