Search Results - "FLOYD, Eugenia"

Pathway analysis using random forests classification and regression by Pang, Herbert, Lin, Aiping, Holford, Matthew, Enerson, Bradley E., Lu, Bin, Lawton, Michael P., Floyd, Eugenia, Zhao, Hongyu

“…Motivation: Although numerous methods have been developed to better capture biological information from microarray data, commonly used single gene-based…”
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The Choice of Region of Interest Measures in Contrast-Enhanced Magnetic Resonance Image Characterization of Experimental Breast Tumors by Preda, Anda, Turetschek, Karl, Daldrup, Heike, Floyd, Eugenia, Novikov, Viktor, Shames, David M, Roberts, Timothy P. L, Carter, Wayne O, Brasch, Robert C

“…OBJECTIVES:The objectives of this study were to determine if magnetic resonance (MR) estimates of quantitative tissue microvascular characteristics from…”
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The Trp53 Hemizygous Mouse in Pharmaceutical Development: Points to Consider for Pathologists by Floyd, Eugenia, Mann, Peter, Long, Gerald, Ochoa, Ricardo

“…ILSI-HESI sponsored an international consortium for the evaluation of alternative models, including the Trp53+ /- mouse, for use in short-term carcinogenicity…”
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Development and Use of Biomarkers in Oncology Drug Development by Floyd, Eugenia, Mcshane, Teresa M.

“…Successful development and use of biomarkers will improve the productivity of oncology drug development. Recognition of the importance of biomarkers for…”
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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor by JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

“…Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach…”
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Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy by Beebe, Jean S, Jani, Jitesh P, Knauth, Elisabeth, Goodwin, Peter, Higdon, Carla, Rossi, Ann Marie, Emerson, Erling, Finkelstein, Martin, Floyd, Eugenia, Harriman, Shawn, Atherton, Jim, Hillerman, Steve, Soderstrom, Cathy, Kou, Kou, Gant, Tom, Noe, Mark C, Foster, Barb, Rastinejad, Farzan, Marx, Matthew A, Schaeffer, Tracey, Whalen, Pamela M, Roberts, W Gregory

“…Signaling through vascular endothelial growth factor (VEGF) receptors (VEGFRs) is a key pathway initiating endothelial cell proliferation and migration…”
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MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats by Fournier, Laure S, Novikov, Viktor, Lucidi, Vincenzo, Fu, Yanjun, Miller, Theodore, Floyd, Eugenia, Shames, David M, Brasch, Robert C

“…To prospectively evaluate the ability of macromolecular contrast medium (MMCM)-enhanced dynamic magnetic resonance (MR) imaging to depict vascular changes in…”
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MR imaging characterization of microvessels in experimental breast tumors by using a particulate contrast agent with histopathologic correlation by Turetschek, K, Huber, S, Floyd, E, Helbich, T, Roberts, T P, Shames, D M, Tarlo, K S, Wendland, M F, Brasch, R C

“…To define the diagnostic potential of magnetic resonance (MR) imaging enhanced with ultrasmall superparamagnetic iron oxide (USPIO) particles for the…”
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MRI monitoring of tumor response following angiogenesis inhibition in an experimental human breast cancer model by TURETSCHEK, Karl, PREDA, Anda, FLOYD, Eugenia, SHAMES, David M, NOVIKOV, Viktor, ROBERTS, Timothy P. L, WOOD, Jeanette M, YANJUN FU, CARTER, Wayne O, BRASCH, Robert C

“…The aim of this study was to evaluate the potential of dynamic magnetic resonance imaging (MRI) enhanced by macromolecular contrast agents to monitor…”
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Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model by Turetschek, Karl, Roberts, Timothy P. L., Floyd, Eugenia, Preda, Anda, Novikov, Viktor, Shames, David M., Carter, Wayne O., Brasch, Robert C.

“…The diagnostic potential of ultrasmall superparamagnetic iron oxide particles (USPIO) for quantitative tumor microvessel characterization was assessed by…”
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MRI assessment of microvascular characteristics in experimental breast tumors using a new blood pool contrast agent (MS-325) with correlations to histopathology by Turetschek, Karl, Floyd, Eugenia, Helbich, Thomas, Roberts, Timothy P.L., Shames, David M., Wendland, Michael F., Carter, Wayne O., Brasch, Robert C.

“…A new contrast medium, MS‐325, was compared to albumin‐(Gd‐DTPA)30 in 18 chemically induced rat breast tumors based on quantitative estimates of microvascular…”
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Acute Drug-Induced Vascular Injury in Beagle Dogs: Pathology and Correlating Genomic Expression by Enerson, Bradley E., Lin, Aiping, Lu, Bin, Zhao, Hongyu, Lawton, Michael P., Floyd, Eugenia

“…Acute vascular injury that leads to vascular inflammation is a common finding in the preclinical toxicity testing of drugs in rats and dogs. However, the…”
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Magnetic resonance characterization of tumor microvessels in experimental breast tumors using a slow clearance blood pool contrast agent (carboxymethyldextran-A2-Gd-DOTA) with histopathological correlation by Preda, Anda, Novikov, Viktor, Möglich, Martina, Floyd, Eugenia, Turetschek, Karl, Shames, David M, Roberts, Timothy P L, Corot, Claire, Carter, Wayne O, Brasch, Robert C

“…Carboxymethyldextran (CMD)-A2-Gd-DOTA, a slow clearance blood pool contrast agent with a molecular weight of 52.1 kDa, designed to have intravascular residence…”
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Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology by Turetschek, Karl, Floyd, Eugenia, Shames, David M., Roberts, Timothy P.L., Preda, Anda, Novikov, Viktor, Corot, Claire, Carter, Wayne O., Brasch, Robert C.

“…The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW = 6.47 kDa) for the MR assessment of microvessel characteristics was…”
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The Trp53 hemizygous mouse in pharmaceutical development: Points to consider for pathologists : Genetically altered models as replacements for the conventional mouse bioassay: Challenges for pathologists in drug development by FLOYD, Eugenia, MANN, Peter, LONG, Gerald, OCHOA, Ricardo

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The anti-tumor activity of anti-CTLA-4 is mediated through its induction of IFN gamma by Paradis, T J, Floyd, E, Burkwit, J, Cole, S H, Brunson, B, Elliott, E, Gilman, S, Gladue, R P

“…The T-cell-specific receptor, CTLA-4, has been demonstrated to be a potent negative regulator of lymphocyte activation, the functional significance of which…”
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MRI monitoring of tumor response to a novel VEGF tyrosine kinase inhibitor in an experimental breast cancer model by Turetschek, Karl, Preda, Anda, Floyd, Eugenia, Shames, David M, Novikov, Viktor, Roberts, Timothy P L, Wood, Jeanette M, Fu, Yanjun, Carter, Wayne O, Brasch, Robert C

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Dynamic MRI enhanced with albumin-(Gd-DTPA)30 or ultrasmall superparamagnetic iron oxide particles (NC100150 injection) for the measurement of microvessel permeability in experimental breast tumors by Turetschek, Karl, Huber, Sabine, Helbich, Thomas, Floyd, Eugenia, Tarlo, Kirk S, Roberts, Timothy P L, Shames, David M, Wendland, Michael F, Brasch, Robert C

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Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy1 by BEEBE, Jean S, JANI, Jitesh P, ATHERTON, Jim, HILLERMAN, Steve, SODERSTROM, Cathy, KOU KOU, GANT, Tom, NOE, Mark C, FOSTER, Barb, RASTINEJAD, Farzan, MARX, Matthew A, SCHAEFFER, Tracey, KNAUTH, Elisabeth, WHALEN, Pamela M, ROBERTS, W. Gregory, GOODWIN, Peter, HIGDON, Carla, ROSSI, Ann Marie, EMERSON, Erling, FINKELSTEIN, Martin, FLOYD, Eugenia, HARRIMAN, Shawn

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The anti-tumor activity of anti-CTLA-4 is mediated through its induction of IFNy by PARADIS, Timothy J, FLOYD, Eugenia, BURKWIT, Jeff, COLE, Susan H, BRUNSON, Brandon, ELLIOTT, Eileen, GILMAN, Steven, GLADUE, Ronald P

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