Search Results - "FLOROS, Joanna"

Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants by Floros, Joanna, Tsotakos, Nikolaos

“…The human and genes encode the surfactant protein A1 (SP-A1) and SP-A2, respectively, and they have been identified with significant genetic and epigenetic…”
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The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0) by Thorenoor, Nithyananda, Floros, Joanna

“…Human surfactant protein (SP)-A1 and SP-A2 exhibit differential qualitative and quantitative effects on the alveolar macrophage (AM), including a differential…”
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Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions by Floros, Joanna, Thorenoor, Nithyananda, Tsotakos, Nikolaos, Phelps, David S.

“…The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect survival after infection in mice and in lung transplant patients. SP-A…”
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Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure by Wang, Guirong, Umstead, Todd M, Hu, Sanmei, Mikerov, Anatoly N, Phelps, David S, Floros, Joanna

“…Surfactant protein A (SP-A) plays critical roles in host defense, regulation of inflammation and surfactant metabolism in the lung. The human SP-A locus…”
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Childhood asthma: causes, risks, and protective factors; a role of innate immunity by Noutsios, Georgios T, Floros, Joanna

“…Childhood asthma is an umbrella of multifactorial diseases with similar clinical features such as mast cell and eosinophil infiltration causing airway hyper…”
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Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae by Thorenoor, Nithyananda, Kawasawa, Yuka Imamura, Gandhi, Chintan K, Floros, Joanna

“…Surfactant protein A (SP-A) in addition to its surfactant-related functions interacts with alveolar macrophages (AM), the guardian cells of innate immunity in…”
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The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue by Phelps, David S., Chinchilli, Vernon M., Yang, Lili, Shearer, Debra, Weisz, Judith, Zhang, Xuesheng, Floros, Joanna

“…Using the Toponome Imaging System (TIS), a serial immunostainer, we studied the patterns of expression of multiple markers in alveolar macrophages (AM) from…”
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Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences by Thorenoor, Nithyananda, Kawasawa, Yuka Imamura, Gandhi, Chintan K, Zhang, Xuesheng, Floros, Joanna

“…In humans there are two surfactant protein A (SP-A) functional genes and encoding innate immune molecules, SP-A1 and SP-A2, respectively, with numerous genetic…”
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Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice by Depicolzuane, Lynnlee, Phelps, David S, Floros, Joanna

“…Pulmonary surfactant proteins have many roles in surfactant- related functions and innate immunity. One of these proteins is the surfactant protein A (SP-A)…”
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Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival by Thorenoor, Nithyananda, Umstead, Todd M, Zhang, Xuesheng, Phelps, David S, Floros, Joanna

“…Surfactant protein A (SP-A) is involved in lung innate host defense and surfactant-related functions. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2…”
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Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis by Lin, Zhenwu, Thorenoor, Nithyananda, Wu, Rongling, DiAngelo, Susan L, Ye, Meixia, Thomas, Neal J, Liao, Xiaojie, Lin, Tony R, Warren, Stuart, Floros, Joanna

“…Surfactant proteins (SP) are involved in surfactant function and innate immunity in the human lung. Both lung function and innate immunity are altered in CF,…”
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Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences by Thorenoor, Nithyananda, Zhang, Xuesheng, Umstead, Todd M, Scott Halstead, E, Phelps, David S, Floros, Joanna

“…Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A…”
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Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis by Abbasi, Ata, Chen, Chixiang, Gandhi, Chintan K., Wu, Rongling, Pardo, Annie, Selman, Moises, Floros, Joanna

“…Surfactant proteins (SPs) are important for normal lung function and innate immunity of the lungs and their genes have been identified with significant genetic…”
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Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection by Phelps, David S, Chinchilli, Vernon M, Zhang, Xuesheng, Shearer, Debra, Weisz, Judith, Floros, Joanna

“…Surfactant protein-A (SP-A) plays a critical role in lung innate immunity by regulating alveolar macrophages (AM), expression of inflammatory mediators, and…”
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High-throughput DNA methylation profiling using universal bead arrays by Bibikova, Marina, Lin, Zhenwu, Zhou, Lixin, Chudin, Eugene, Garcia, Eliza Wickham, Wu, Bonnie, Doucet, Dennis, Thomas, Neal J, Wang, Yunhua, Vollmer, Ekkehard, Goldmann, Torsten, Seifart, Carola, Jiang, Wei, Barker, David L, Chee, Mark S, Floros, Joanna, Fan, Jian-Bing

“…We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the…”
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Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure by Thorenoor, Nithyananda, Phelps, David S, Floros, Joanna

“…Human SP-A1 and SP-A2, encoded by and , and their genetic variants differentially impact alveolar macrophage (AM) functions and regulation, including the…”
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SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children by Gandhi, Chintan K, Thomas, Neal J, Meixia, Ye, Spear, Debbie, Fu, Chenqi, Zhou, Shouhao, Wu, Rongling, Keim, Garrett, Yehya, Nadir, Floros, Joanna

“…We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after acute respiratory failure (ARF) in previously healthy children with…”
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Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children by Depicolzuane, Lynnlee C., Roberts, Catherine M., Thomas, Neal J., Anderson-Fears, Keenan, Liu, Dajiang, Barbosa, João Paulo Pereira, Souza, Felipe Rodrigues, Pimentel, André Silva, Floros, Joanna, Gandhi, Chintan K.

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection-related hospitalization in the first year of life. Surfactant…”
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Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome by Noutsios, George T, Thorenoor, Nithyananda, Zhang, Xuesheng, Phelps, David S, Umstead, Todd M, Durrani, Faryal, Floros, Joanna

“…Pulmonary surfactant protein A (SP-A) plays an important role in surfactant metabolism and lung innate immunity. In humans there are two proteins, SP-A1 and…”
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Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data by Nalian, Armen, Umstead, Todd M, Yang, Ching-Hui, Silveyra, Patricia, Thomas, Neal J, Floros, Joanna, McCormack, Francis X, Chroneos, Zissis C

“…Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens,…”
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