Search Results - "FLINT, Mike"

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses by Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.

“…GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It…”
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In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses by Lo, Michael K., Shi, Pei-Yong, Chen, Yen-Liang, Flint, Mike, Spiropoulou, Christina F.

“…There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV),…”
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Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus by Welch, Stephen R., Scholte, Florine E.M., Flint, Mike, Chatterjee, Payel, Nichol, Stuart T., Bergeron, Éric, Spiropoulou, Christina F.

“…Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne orthonairovirus, causes a severe hemorrhagic disease in humans (Crimean-Congo hemorrhagic fever,…”
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Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing by Shrivastava-Ranjan, Punya, Flint, Mike, Bergeron, Éric, McElroy, Anita K, Chatterjee, Payel, Albariño, César G, Nichol, Stuart T, Spiropoulou, Christina F

“…Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and limited effective treatments. Statins, widely used…”
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A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus by Flint, Mike, Chatterjee, Payel, Lin, David L., McMullan, Laura K., Shrivastava-Ranjan, Punya, Bergeron, Éric, Lo, Michael K., Welch, Stephen R., Nichol, Stuart T., Tai, Andrew W., Spiropoulou, Christina F.

“…There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus…”
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25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation by Shrivastava-Ranjan, Punya, Bergeron, Éric, Chakrabarti, Ayan K, Albariño, César G, Flint, Mike, Nichol, Stuart T, Spiropoulou, Christina F

“…Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene…”
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Host mTORC1 Signaling Regulates Andes Virus Replication by McNulty, Shannon, Flint, Mike, Nichol, Stuart T, Spiropoulou, Christina F

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Hepatitis C Virus Glycoproteins Mediate pH-Dependent Cell Entry of Pseudotyped Retroviral Particles by Hsu, Mayla, Zhang, Jie, Flint, Mike, Logvinoff, Carine, Cheng-Mayer, Cecilia, Rice, Charles M., McKeating, Jane A.

“…HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5…”
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Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity by Yates, Mary K, Chatterjee, Payel, Flint, Mike, Arefeayne, Yafet, Makuc, Damjan, Plavec, Janez, Spiropoulou, Christina F, Seley-Radtke, Katherine L

“…Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of…”
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Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses by FLINT, Mike, McMULLAN, Laura K, DODD, Kimberl A, BIRD, Brian H, KHRISTOVA, Marina L, NICHOL, Stuart T, SPIROPOULOU, Christina F

“…No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical…”
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A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile by Donald, Robert G K, Flint, Mike, Kalyan, Narender, Johnson, Erik, Witko, Susan E, Kotash, Cheryl, Zhao, Ping, Megati, Shakuntala, Yurgelonis, Irina, Lee, Phillip Kwok, Matsuka, Yury V, Severina, Elena, Deatly, Anne, Sidhu, Mini, Jansen, Kathrin U, Minton, Nigel P, Anderson, Annaliesa S

“…The Clostridium difficile toxins A and B are primarily responsible for symptoms of C. difficile associated disease and are prime targets for vaccine…”
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Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells by Chiang, Cheng-Feng, Flint, Mike, Lin, Jin-Mann S, Spiropoulou, Christina F

“…Andes virus (ANDV) is the major cause of hantavirus pulmonary syndrome (HPS) in South America. Despite a high fatality rate (up to 40%), no vaccines or…”
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Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524) by Lo, Michael K, Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R, Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T, Hostetler, Karl Y, Montgomery, Joel M, Spiropoulou, Christina F

“…The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients…”
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Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture by Shrivastava-Ranjan, Punya, Lo, Michael K, Chatterjee, Payel, Flint, Mike, Nichol, Stuart T, Montgomery, Joel M, O'Keefe, Barry R, Spiropoulou, Christina F

“…Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics…”
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Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform by Welch, Stephen R, Spengler, Jessica R, Genzer, Sarah C, Chatterjee, Payel, Flint, Mike, Bergeron, Éric, Montgomery, Joel M, Nichol, Stuart T, Albariño, César G, Spiropoulou, Christina F

“…Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we…”
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The Major Determinant of Attenuation in Mice of the Candid1 Vaccine for Argentine Hemorrhagic Fever Is Located in the G2 Glycoprotein Transmembrane Domain by ALBARINO, César G, BIRD, Brian H, CHAKRABARTI, Ayan K, DODD, Kimberly A, FLINT, Mike, BERGERON, Eric, WHITE, David M, NICHOL, Stuart T

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Diverse CD81 Proteins Support Hepatitis C Virus Infection by FLINT, Mike, VON HAHN, Thomas, JIE ZHANG, FARQUHAR, Michelle, JONES, Christopher T, BALFE, Peter, RICE, Charles M, MCKEATING, Jane A

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Optimization of Molecular Approaches to Genogroup Neisseria meningitidis Carriage Isolates and Implications for Monitoring the Impact of New Serogroup B Vaccines by Rojas, Eduardo, Hoyos, Johanna, Oldfield, Neil J, Lee, Philip, Flint, Mike, Jones, C Hal, Ala'Aldeen, Dlawer A A, Jansen, Kathrin U, Anderson, Annaliesa S

“…The reservoir for Neisseria meningitidis (Nm) is the human oropharynx. Implementation of Nm serogroup C (NmC) glycoconjugate vaccines directly reduced NmC…”
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Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81 by Flint, Mike, Maidens, Catherine, Loomis-Price, Larry D., Shotton, Christine, Dubuisson, Jean, Monk, Peter, Higginbottom, Adrian, Levy, Shoshana, McKeating, Jane A.

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The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis by Quinn, Elizabeth R., Chan, Chunghuang Hubert, Hadlock, Kenneth G., Foung, Steven K.H., Flint, Mike, Levy, Shoshana

“…Hepatitis C virus (HCV) infection is associated with extrahepatic B-cell lymphoproliferative disorders. To determine whether a viral antigen drives this B-cell…”
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