Search Results - "FLIERS, Eric"

Thyroid function in critically ill patients by Fliers, Eric, Prof, Bianco, Antonio C, Prof, Langouche, Lies, PhD, Boelen, Anita, Dr

“…Summary Patients in the intensive care unit (ICU) typically present with decreased concentrations of plasma tri-iodothyronine, low thyroxine, and normal range…”
Get full text

The classic pathways of thyroid hormone metabolism by van der Spek, Anne H., Fliers, Eric, Boelen, Anita

“…Thyroid hormones (TH) are crucial for growth and development and play an important role in energy homeostasis. Although serum TH levels are relatively constant…”
Get full text

MECHANISMS IN ENDOCRINOLOGY: Beyond the fixed setpoint of the hypothalamus–pituitary–thyroid axis by Fliers, Eric, Kalsbeek, Andries, Boelen, Anita

“…The hypothalamus–pituitary–thyroid (HPT) axis represents a classical example of an endocrine feedback loop. This review discusses dynamic changes in HPT axis…”
Get full text

The molecular basis of the non-thyroidal illness syndrome by de Vries, Emmely M, Fliers, Eric, Boelen, Anita

“…The ‘sick euthyroid syndrome’ or ‘non-thyroidal illness syndrome’ (NTIS) occurs in a large proportion of hospitalized patients and comprises a variety of…”
Get full text

Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats by Opperhuizen, Anne-Loes, Stenvers, Dirk J., Jansen, Remi D., Foppen, Ewout, Fliers, Eric, Kalsbeek, Andries

“…Aims/hypothesis Exposure to light at night (LAN) has increased dramatically in recent decades. Animal studies have shown that chronic dim LAN induced obesity…”
Get full text

Gut microbiota and metabolites in the pathogenesis of endocrine disease by Fenneman, Aline C, Rampanelli, Elena, Yin, Yue S, Ames, Jesse, Blaser, Martin J, Fliers, Eric, Nieuwdorp, Max

“…Type 1 diabetes (T1D) and Hashimoto's thyroiditis (HT) are the two most common autoimmune endocrine diseases that have rising global incidence. These diseases…”
Get more information

2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism by Persani, Luca, Brabant, Georg, Dattani, Mehul, Bonomi, Marco, Feldt-Rasmussen, Ulla, Fliers, Eric, Gruters, Annette, Maiter, Dominique, Schoenmakers, Nadia, van Trotsenburg, A.S. Paul

“…Objectives: Central hypothyroidism (CeH) is a rare form of hypothyroidism characterized by insufficient thyroid stimulation due to disturbed pituitary and/or…”
Get full text

Effects of Intracerebroventricular Administration of Neuropeptide Y on Metabolic Gene Expression and Energy Metabolism in Male Rats by Su, Yan, Foppen, Ewout, Fliers, Eric, Kalsbeek, Andries

“…Neuropeptide Y (NPY) is an important neurotransmitter in the control of energy metabolism. Several studies have shown that obesity is associated with increased…”
Get full text

Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review by van Dijk, Myrthe M, Smits, Iris H, Fliers, Eric, Bisschop, Peter H

“…In pregnant women with Graves' disease, maternal thyrotropin receptor antibodies (TRAb) can cross the placenta and induce fetal or neonatal thyrotoxicosis…”
Get more information

TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold by Zhang, Zhi, Boelen, Anita, Kalsbeek, Andries, Fliers, Eric

“…Thyroid hormone (TH) plays a key role in regulating body temperature in mammals. Cold exposure stimulates the hypothalamus-pituitary-thyroid (HPT) axis at the…”
Get full text

Clues for Polygenic Inheritance of Pituitary Stalk Interruption Syndrome From Exome Sequencing in 20 Patients by Zwaveling-Soonawala, Nitash, Alders, Marielle, Jongejan, Aldo, Kovačič, Lidija, Duijkers, Floor A, Maas, Saskia M, Fliers, Eric, van Trotsenburg, A S Paul, Hennekam, Raoul C

“…Abstract Context Pituitary stalk interruption syndrome (PSIS) consists of a small/absent anterior pituitary lobe, an interrupted/absent pituitary stalk, and an…”
Get full text

Feeding during the resting phase causes profound changes in physiology and desynchronization between liver and muscle rhythms of rats by Opperhuizen, Anne-Loes, Wang, Dawei, Foppen, Ewout, Jansen, Remi, Boudzovitch-Surovtseva, Olga, de Vries, Janneke, Fliers, Eric, Kalsbeek, Andries

“…Shiftworkers run an increased risk of developing metabolic disorders, presumably as a result of disturbed circadian physiology. Eating at a time‐of‐day that is…”
Get full text

Hypothyroidism: The difficulty in attributing symptoms to their underlying cause by Jansen, Heleen I, Boelen, Anita, Heijboer, Annemieke C, Bruinstroop, Eveline, Fliers, Eric

“…Common symptoms of overt hypothyroidism are non-specific and include fatigue, lethargy, and dry skin. Although the diagnosis is considered to be…”
Get full text

The role of the autonomic nervous liver innervation in the control of energy metabolism by Yi, Chun-Xia, la Fleur, Susanne E., Fliers, Eric, Kalsbeek, Andries

“…Despite a longstanding research interest ever since the early work by Claude Bernard, the functional significance of autonomic liver innervation, either…”
Get full text

Protocol for a double-blinded randomised controlled trial to assess the effect of faecal microbiota transplantations on thyroid reserve in patients with subclinical autoimmune hypothyroidism in the Netherlands: the IMITHOT trial by Fenneman, Aline C, Rampanelli, Elena, van der Spek, Anne H, Fliers, Eric, Nieuwdorp, Max

“…Background Hashimoto’s thyroiditis (HT) is a common endocrine autoimmune disease affecting roughly 5% of the general population and involves life-long…”
Get full text

Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function by van der Spek, Anne H, Surovtseva, Olga V, Jim, Kin Ki, van Oudenaren, Adri, Brouwer, Matthijs C, Vandenbroucke-Grauls, Christina M J E, Leenen, Pieter J M, van de Beek, Diederik, Hernandez, Arturo, Fliers, Eric, Boelen, Anita

“…Innate immune cells, including macrophages, have recently been identified as target cells for thyroid hormone. We hypothesized that optimal intracellular…”
Get full text

Novel neural pathways for metabolic effects of thyroid hormone by Fliers, Eric, Klieverik, Lars P, Kalsbeek, Andries

“…The relation between thyrotoxicosis, the clinical syndrome resulting from exposure to excessive thyroid hormone concentrations, and the sympathetic nervous…”
Get full text

Circadian disruption and SCN control of energy metabolism by Kalsbeek, Andries, Scheer, Frank A., Perreau-Lenz, Stephanie, La Fleur, Susanne E., Yi, Chun-Xia, Fliers, Eric, Buijs, Ruud M.

“…In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy…”
Get full text

Quality of life, daily functioning, and symptoms in hypothyroid patients on thyroid replacement therapy: A Dutch survey by Molewijk, Ellen, Fliers, Eric, Dreijerink, Koen, van Dooren, Ad, Heerdink, Rob

“…[Display omitted] •Hypothyroid patients on thyroid replacement therapy (n = 1000–1200):•had large-sized impairments of quality of life (QoL) vs controls,•had…”
Get full text

The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity by van Galen, Katy A., Booij, Jan, Schrantee, Anouk, Adriaanse, Sofie M., Unmehopa, Unga A., Fliers, Eric, Schwartz, Gary J., DiLeone, Ralph J., ter Horst, Kasper W., la Fleur, Susanne E., Serlie, Mireille J.

“…Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy…”
Get full text