Search Results - "FLIER, J. S"

What's in a name? In search of leptin's physiologic role by FLIER, J. S

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Leptin by Ahima, R S, Flier, J S

“…The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in…”
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A Transgenic Model of Visceral Obesity and the Metabolic Syndrome by Masuzaki, Hiroaki, Paterson, Janice, Shinyama, Hiroshi, Morton, Nicholas M., Mullins, John J., Seckl, Jonathan R., Flier, Jeffrey S.

“…The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce visceral obesity and diabetes,…”
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Role of leptin in the neuroendocrine response to fasting by Ahima, R.S, Prabakaran, D, Mantzoros, C, Qu, D, Lowell, B, Maratos-Flier, E, Flier, J.S

“…A total deficiency in or resistance to the protein leptin causes severe obesity. As leptin levels rise with increasing adiposity in rodents and man, it is…”
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Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation by UOTANI, S, BJØRBAEK, C, TORNØE, J, FLIER, J. S

“…Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. S Uotani , C Bjørbaek…”
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Mice lacking melanin-concentrating hormone are hypophagic and lean by Maratos-Flier, Eleftheria, Shimada, Masako, Tritos, Nicholas A, Lowell, Bradford B, Flier, Jeffrey S

“…Feeding is influenced by hypothalamic neuropeptides that promote (orexigenic peptides) or inhibit feeding. Of these, neuropeptide Y (NPY) in the arcuate…”
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Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function by Ahima, R S, Prabakaran, D, Flier, J S

“…Leptin is thought to regulate energy balance through effects on food intake and thermogenesis. In addition, leptin may serve as a mediator of the…”
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Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways by Nillni, E A, Vaslet, C, Harris, M, Hollenberg, A, Bjørbak, C, Flier, J S

“…The hypothalamic-pituitary-thyroid axis is down-regulated during starvation, and falling levels of leptin are a critical signal for this adaptation, acting to…”
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Leptin accelerates the onset of puberty in normal female mice by Ahima, R S, Dushay, J, Flier, S N, Prabakaran, D, Flier, J S

“…The fat-derived hormone, leptin, is proposed to serve as an adipostatic signal to the brain to reduce food intake and body weight. In addition to its effects…”
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α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors by Robins, S.C., Stewart, I., McNay, D.E., Taylor, V., Giachino, C., Goetz, M., Ninkovic, J., Briancon, N., Maratos-Flier, E., Flier, J.S., Kokoeva, M.V., Placzek, M.

“…Emerging evidence suggests that new cells, including neurons, can be generated within the adult hypothalamus, suggesting the existence of a local neural…”
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Unraveling the central nervous system pathways underlying responses to leptin by Elmquist, Joel K, Maratos-Flier, Eleftheria, Saper, Clifford B, Flier, Jeffrey S

“…Here we summarize recent progress in the biology of leptin, concentrating on its central nervous system (CNS) actions. The product of the ob gene, leptin is a…”
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Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice by Mantzoros, C S, Qu, D, Frederich, R C, Susulic, V S, Lowell, B B, Maratos-Flier, E, Flier, J S

“…Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. C S Mantzoros , D…”
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Editorial: leptin as a therapeutic agent--trials and tribulations by Mantzoros, C S, Flier, J S

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BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY by Lowell, MD, PhD, B. B, Flier, MD, J. S

“…Brown adipose tissue is distinguished by its unique capacity for uncoupled mitochondrial respiration, which is highly regulated by sympathetic nerve activity…”
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Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids by Vidal-Puig, A J, Considine, R V, Jimenez-Liñan, M, Werman, A, Pories, W J, Caro, J F, Flier, J S

“…The peroxisome proliferator activated receptor (PPAR gamma) plays a key role in adipogenesis and adipocyte gene expression and is the receptor for the…”
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Regulation of PPAR gamma gene expression by nutrition and obesity in rodents by Vidal-Puig, A, Jimenez-Liñan, M, Lowell, B B, Hamann, A, Hu, E, Spiegelman, B, Flier, J S, Moller, D E

“…The orphan nuclear receptor, peroxisome proliferator-activated receptor (PPAR) gamma, is implicated in mediating expression of fat-specific genes and in…”
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Leptin activates neurons in ventrobasal hypothalamus and brainstem by ELMQUIST, J. K, AHIMA, R. S, MARATOS-FLIER, E, FLIER, J. S, SAPER, C. B

“…Leptin is a circulating protein secreted by adipocytes which has profound feeding, metabolic, and neuroendocrine effects. Leptin receptors have been localized…”
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Leptin concentrations in relation to body mass index and the tumor necrosis factor-α system in humans by MANTZOROS, C. S, MOSCHOS, S, AVRAMOPOULOS, I, KAKLAMANI, V, LIOLIOS, A, DOULGERAKIS, D. E, GRIVEAS, I, KATSILAMBROS, N, FLIER, J. S

“…The expression of leptin, an adipocyte-derived protein whose circulating levels reflect energy stores, can be induced by tumor necrosis factor (TNF)alpha in…”
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Leptin concentrations in the polycystic ovary syndrome by MANTZOROS, C. S, DUNAIF, A, FLIER, J. S

“…The polycystic ovary syndrome (PCOS) is characterized by menstrual disturbances, chronic anovulation and hyperandrogenism and is associated with insulin…”
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Leptin expression and action: new experimental paradigms by Flier, J.S. (Beth Israel Deaconess Medical Center, Boston, MA.)

“…An exciting new era in nutritional physiology and obesity research has been ushered in by the identification of the ob gene through positional cloning and the…”
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