Search Results - "FLETCHER, Paul J"

Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus by Abela, Andrew R., Browne, Caleb J., Sargin, Derya, Prevot, Thomas D., Ji, Xiao Dong, Li, Zhaoxia, Lambe, Evelyn K., Fletcher, Paul J.

“…Anxiety disorders may be mediated in part by disruptions in serotonin (5-hydroxytryptamine, 5-HT) system function. Behavioral measures of approach-avoidance…”
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From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists by Higgins, Guy A, Sellers, Edward M, Fletcher, Paul J

“…Highlights • We propose drug abuse/addiction as a therapeutic target for 5-HT2C receptor agonists. • 5-HT2C agonists may exert anti-obesity and anti-addictive…”
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A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects by Su, Ping, Li, Shupeng, Chen, Sheng, Lipina, Tatiana V., Wang, Min, Lai, Terence K.Y., Lee, Frankie H.F., Zhang, Hailong, Zhai, Dongxu, Ferguson, Stephen S.G., Nobrega, José N., Wong, Albert H.C., Roder, John C., Fletcher, Paul J., Liu, Fang

“…Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these…”
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Opposing effects of 5-HT2A and 5-HT2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test by FLETCHER, Paul J, TAMPAKERAS, Maria, SINYARD, Judy, HIGGINS, Guy A

“…Rationale Serotonin (5-HT) has been linked to impulsivity with recent data suggesting that different receptor sub-types exert opposing influences on this…”
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Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects by Liu, Fang, Pei, Lin, Li, Shupeng, Wang, Min, Diwan, Mustansir, Anisman, Hymie, Fletcher, Paul J, Nobrega, José N

“…We report that coupling between dopamine D1 and D2 receptors was markedly increased in postmortem brain of subjects suffering from major depression…”
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The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control by HIGGINS, Guy A, SILENIEKS, Leo B, ROSSMANN, Anne, RIZOS, Zoe, NOBLE, Kevin, SOKO, Ashlie D, FLETCHER, Paul J

“…Lorcaserin ((1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine HCl) is a selective 5-HT(2C) receptor agonist with clinical efficacy in phase-III…”
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Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice by Browne, Caleb J, Ji, Xiaodong, Higgins, Guy A, Fletcher, Paul J, Harvey-Lewis, Colin

“…Converging lines of behavioral, electrophysiological, and biochemical evidence suggest that 5-HT2C receptor signaling may bidirectionally influence…”
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Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors : Comparing aripiprazole to other antipsychotics in animal models by NATESAN, Sridhar, RECKLESS, Greg E, NOBREGA, José N, FLETCHER, Paul J, KAPUR, Shitij

“…The novel antipsychotic aripiprazole requires high (>90%) striatal D2 receptor occupancy (D2RO) to be clinically active, but despite its high D2RO it does not…”
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Impulsive action in the 5-choice serial reaction time test in 5-HT2C receptor null mutant mice by Fletcher, Paul J., Soko, Ashlie D., Higgins, Guy A.

“…Rationale Depletion of brain serotonin (5-HT) results in impulsive behaviour as measured by increased premature responding in the five-choice serial reaction…”
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Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB by Hasbi, Ahmed, Perreault, Melissa L, Shen, Maurice Y F, Fan, Theresa, Nguyen, Tuan, Alijaniaram, Mohammed, Banasikowski, Tomek J, Grace, Anthony A, O'Dowd, Brian F, Fletcher, Paul J, George, Susan R

“…A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but…”
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Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats by Zack, Martin, Featherstone, Robert E, Mathewson, Sarah, Fletcher, Paul J

“…Addiction is considered to be a brain disease caused by chronic exposure to drugs. Sensitization of brain dopamine (DA) systems partly mediates this effect…”
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Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice by Feldcamp, Laura, Doucet, Jean-Sebastien, Pawling, Judy, Fadel, Marc P., Fletcher, Paul J., Maunder, Robert, Dennis, James W., Wong, Albert H.C.

“…•Mgat5−/− mice show a less depression-like phenotype.•Mgat5−/− mice have higher bone density and lower blood glucose levels.•Cortical neuron spine density is…”
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Abnormalities in brain structure and behavior in GSK-3alpha mutant mice by Kaidanovich-Beilin, Oksana, Lipina, Tatiana V, Takao, Keizo, van Eede, Matthijs, Hattori, Satoko, Laliberté, Christine, Khan, Mustafa, Okamoto, Kenichi, Chambers, John W, Fletcher, Paul J, MacAulay, Katrina, Doble, Bradley W, Henkelman, Mark, Miyakawa, Tsuyoshi, Roder, John, Woodgett, James R

“…Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related…”
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Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization by Wang, Min, Pei, Lin, Fletcher, Paul J, Kapur, Shitij, Seeman, Philip, Liu, Fang

“…All antipsychotics work via dopamine D2 receptors (D2Rs), suggesting a critical role for D2Rs in psychosis; however, there is little evidence for a change in…”
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Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test by Rahbarnia, Arya, Li, Zhaoxia, Fletcher, Paul J.

“…RATIONALENeuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by the serotonin (5-HT)…”
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The effects of the 5-HT2c receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists by FLETCHER, Paul J, SINYARD, Judy, HIGGINS, Guy A

“…Rationale: The 5-HT2C receptor modulates mesolimbic dopamine (DA) function and the expression of DA-dependent behaviors, including stimulant-induced…”
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Insulin Resistance and Decreased Glucose-Stimulated Insulin Secretion After Acute Olanzapine Administration by CHINTOH, Araba F, MANN, Steve W, LAM, Loretta, LAM, Carol, COHN, Tony A, FLETCHER, Paul J, NOBREGA, Jose N, GIACCA, Adria, REMINGTON, Gary

“…The newer atypical antipsychotics, as a class, have been associated with an increased risk of weight gain and metabolic abnormalities. The mechanisms…”
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Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential by Higgins, Guy A., Fletcher, Paul J., Shanahan, William R.

“…The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification, was approved by the FDA in 2012 for weight management. It has…”
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Assessing the stability of responding of male mice in the touchscreen 5 choice serial reaction time task: Focus on premature responding by Rahbarnia, Arya, Abela, Andrew R, Fletcher, Paul J

“…The five-choice serial reaction time task (5CSRTT) is a test of attention that provides a well-validated ancillary measure of impulsive action, measured by…”
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Effects of 5-HT depletion in the frontal cortex or nucleus accumbens on response inhibition measured in the 5-choice serial reaction time test and on a DRL schedule by Fletcher, Paul J., Chambers, John W., Rizos, Zoë, Chintoh, Araba F.

“…Previous work has shown that global depletion of brain serotonin (5-HT) using the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) increases impulsive like…”
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