Search Results - "FLETCHER, Christopher D"

Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics by Schaefer, Inga-Marie, Fletcher, Christopher DM, Hornick, Jason L

“…The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex…”
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Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma by Antonescu, Cristina R., Le Loarer, Francois, Mosquera, Juan-Miguel, Sboner, Andrea, Zhang, Lei, Chen, Chun-Liang, Chen, Hsiao-Wei, Pathan, Nursat, Krausz, Thomas, Dickson, Brendan C., Weinreb, Ilan, Rubin, Mark A., Hameed, Meera, Fletcher, Christopher D. M.

“…Conventional epithelioid hemangioendotheliomas (EHE) have a distinctive morphologic appearance and are characterized by a recurrent t(1;3) translocation,…”
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PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies by CHEN, Benjamin J, CHAPUY, Bjoern, RODIG, Scott J, OUYANG, Jing, SUN, Heather H, ROEMER, Margaretha G. M, XU, Mina L, HONGBO YU, FLETCHER, Christopher D. M, FREEMAN, Gordon J, SHIPP, Margaret A

“…Programmed cell death ligand 1 (PD-L1) is an immunomodulatory molecule expressed by antigen-presenting cells and select tumors that engages receptors on T…”
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Loss of expression of YAP1 C-terminus as an ancillary marker for epithelioid hemangioendothelioma variant with YAP1-TFE3 fusion and other YAP1-related vascular neoplasms by Anderson, William J., Fletcher, Christopher D.M., Hornick, Jason L.

“…Epithelioid hemangioendothelioma (EHE) with YAP1-TFE3 fusion is a recently characterized distinctive variant of EHE that accounts for a small subset (<5%) of…”
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Inflammatory myofibroblastic tumor : Comparison of clinicopathologic, histologic, and immunohistochemical features including alk expression in atypical and aggressive cases by COFFIN, Cheryl M, HORNICK, Jason L, FLETCHER, Christopher D. M

“…Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. In this study, we report a subset of IMTs with histologic atypia…”
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Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST) by Atiq, Mazen A., Davis, Jessica L., Hornick, Jason L., Dickson, Brendan C., Fletcher, Christopher D.M., Fletcher, Jonathan A., Folpe, Andrew L., Mariño-Enríquez, Adrián

“…Mesenchymal tumors driven by NTRK fusions are clinically and morphologically heterogeneous. With an increasing number of clinicopathological entities being…”
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MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma by DOYLE, Leona A, MÖLLER, Emely, DAL CIN, Paola, FLETCHER, Christopher D. M, MERTENS, Fredrik, HORNICK, Jason L

“…Low-grade fibromyxoid sarcoma (LGFMS) is a distinctive fibroblastic neoplasm that is characterized by alternating collagenous and myxoid areas, deceptively…”
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Pseudomyogenic Hemangioendothelioma: A Distinctive, Often Multicentric Tumor With Indolent Behavior by HORNICK, Jason L, FLETCHER, Christopher D. M

“…A 1992 report described 5 keratin-positive spindle cell neoplasms with multifocal presentation in a single limb, which were proposed at that time to be a…”
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Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma by Shanmugam, Vignesh, Griffin, Gabriel K., Jacobsen, Eric D., Fletcher, Christopher D. M., Sholl, Lynette M., Hornick, Jason L.

“…Recent studies have demonstrated recurrent activating mutations involving the classical MAPK and PI3K signaling pathways in a large proportion of histiocytic…”
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Loss of INI1 Expression is Characteristic of Both Conventional and Proximal-type Epithelioid Sarcoma by HORNICK, Jason L, DAL CIN, Paola, FLETCHER, Christopher D. M

“…INI1 (hSNF5/SMARCB1), a member of the SWI/SNF chromatin remodeling complex located on chromosome 22q11.2, is deleted or/or mutated in strictly defined…”
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Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases by Sioletic, Stefano, Dal Cin, Paola, Fletcher, Christopher D M, Hornick, Jason L

“…Aims:  Occasional cases of well‐differentiated and dedifferentiated liposarcoma (LPS) contain myxoid stroma, leading to confusion with other sarcomas. The aim…”
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Monoclonal Antibody DOG1.1 Shows Higher Sensitivity Than KIT in the Diagnosis of Gastrointestinal Stromal Tumors, Including Unusual Subtypes by LIEGL, Bernadette, HORNICK, Jason L, CORLESS, Christopher L, FLETCHER, Christopher D. M

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Approximately 85% of GISTs harbor activating…”
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Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pathologic entities by Specht, Katja, Sung, Yun-Shao, Zhang, Lei, Richter, Günther H. S., Fletcher, Christopher D., Antonescu, Cristina R.

“…Round cell sarcomas harboring CIC‐DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to…”
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Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1—a consensus overview by Miettinen, Markku M., Antonescu, Cristina R., Fletcher, Christopher D.M., Kim, Aerang, Lazar, Alexander J., Quezado, Martha M., Reilly, Karlyne M., Stemmer-Rachamimov, Anat, Stewart, Douglas R., Viskochil, David, Widemann, Brigitte, Perry, Arie

“…Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST)…”
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PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells by Hofvander, Jakob, Jo, Vickie Y., Fletcher, Christopher D. M., Puls, Florian, Flucke, Uta, Nilsson, Jenny, Magnusson, Linda, Mertens, Fredrik

“…Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. PHF1 encodes plant…”
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A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma by Walther, Charles, Tayebwa, Johnbosco, Lilljebjörn, Henrik, Magnusson, Linda, Nilsson, Jenny, von Steyern, Fredrik Vult, Øra, Ingrid, Domanski, Henryk A, Fioretos, Thoas, Nord, Karolin H, Fletcher, Christopher DM, Mertens, Fredrik

“…Pseudomyogenic haemangioendothelioma (PHE) is an intermediate malignant vascular soft tissue tumour primarily affecting children and young adults. The…”
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Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis by Liu, Yajuan J., Wang, Wenjing, Yeh, Jeffrey, Wu, Yu, Mantilla, Jose G., Fletcher, Christopher D.M., Ricciotti, Robert W., Chen, Eleanor Y.

“…Translocations involving FN1 have been described in a variety of neoplasms that share the presence of a cartilage matrix and may also contain a variable extent…”
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Myoepithelial Carcinoma of Soft Tissue in Children : An Aggressive Neoplasm Analyzed in a Series of 29 Cases by GLEASON, Briana C, FLETCHER, Christopher D. M

“…Primary myoepithelial tumors of soft tissue are uncommon, and criteria for malignancy among these neoplasms have only recently been established. Of 51…”
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TERT promoter mutations and prognosis in solitary fibrous tumor by Bahrami, Armita, Lee, Seungjae, Schaefer, Inga-Marie, Boland, Jennifer M, Patton, Kurt T, Pounds, Stanley, Fletcher, Christopher D

“…Solitary fibrous tumor is a mesenchymal neoplasm exhibiting a broad spectrum of biological behavior and harboring the NAB2 – STAT6 fusion. Clinicopathologic…”
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Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas by Baranov, Esther, Black, Margaret A., Fletcher, Christopher D.M., Charville, Gregory W., Hornick, Jason L.

“…Myxoid liposarcoma (MLPS) is a malignant adipocytic neoplasm with predilection for the extremities. MLPS is genetically defined by a t(12;16) translocation…”
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