Search Results - "FLEISHAKER, J. C"

Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression by FLEISHAKER, Joseph C

“…Reboxetine is a novel selective norepinephrine inhibitor that has been evaluated in the treatment of patients with depression. Reboxetine is a racemic mixture,…”
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Proof of Concept: A PhRMA Position Paper With Recommendations for Best Practice by Cartwright, M E, Cohen, S, Fleishaker, J C, Madani, S, McLeod, J F, Musser, B, Williams, S A

“…Proof of concept (POC) may be defined as the earliest point in the drug development process at which the weight of evidence suggests that it is “reasonably…”
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A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine by FLEISHAKER, J. C, HULST, L. K

“…We have assessed the pharmacokinetic and pharmacodynamic interaction between fluvoxamine, a serotonin reuptake inhibitor, and alprazolam, a…”
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Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine by LASHER, T. A, FLEISHAKER, J. C, STEENWYK, R. C, ANTAL, E. J

“…The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in…”
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A comparison of the pharmacokinetics and tolerability of the anti-migraine compound almotriptan in healthy adolescents and adults by Baldwin, J R, Fleishaker, J C, Azie, N E, Carel, B J

“…This study was designed to assess and compare the pharmacokinetics and tolerability of almotriptan, a 5-HT1B/1D agonist used to treat migraine attacks, in…”
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Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans by Herman, Beth D., Fleishaker, Joseph C., Brown, Mark T.

“…Background Ketoconazole is a potent inhibitor of the cytochrome P450 3A4 enzyme. Reboxetine, a selective norepinephrine reuptake inhibitor, is metabolized by…”
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Alprazolam absorption kinetics affects abuse liability by Mumford, G K, Evans, S M, Fleishaker, J C, Griffiths, R R

“…To evaluate the behavioral, subjective, and reinforcing effects of immediate-release (IR) alprazolam and extended-release (XR) alprazolam to assess the effect…”
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Evaluation of the Potential Pharmacokinetic Interaction between Almotriptan and Fluoxetine in Healthy Volunteers by Fleishaker, Joseph C., Ryan, Kristi K., Carel, Barbara J., Azie, Nkechi E.

“…This study was designed to assess the pharmacokinetics of almotriptan, a 5HT1B/1D agonist used to treat migraine attacks, when administered in the presence and…”
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Pharmacokinetics of reboxetine in elderly patients with depressive disorders by Poggesi, I, Pellizzoni, C, Fleishaker, J C

“…To examine the pharmacokinetic characteristics of the selective norepinephrine reuptake inhibitor, reboxetine, in elderly patients with depression. Twelve…”
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Phenytoin causes a rapid increase in 6 beta-hydroxycortisol urinary excretion in humans--a putative measure of CYP3A induction by Fleishaker, J C, Pearson, L K, Peters, G R

“…This study was conducted in eight healthy volunteers to assess the time course of induction of cytochrome P-450 by phenytoin. subjects received 200 mg of…”
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Pharmacokinetics of reboxetine in healthy volunteers with different ethnic descents by HENDERSHOT, Pamela E, FLEISHAKER, Joseph C, LIN, Keh-Ming, NUCCIO, Inocencia D, POLAND, Russell E

“…Ethnicity can affect the pharmacokinetics and pharmacodynamics of psychopharmacologic drugs. Reboxetine disposition differences among Asians, blacks, and…”
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Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: I. Single-dose administration by Fleishaker, J C, Peters, G R, Cathcart, K S

“…The single-dose tolerability and pharmacokinetics of tirilazad mesylate, a 21-aminosteroid free radical scavenger, were assessed in 47 healthy male subjects…”
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Pharmacokinetics of Single-Dose Reboxetine in Volunteers with Renal Insufficiency by Coulomb, François, Ducret, Francis, Laneury, Jean-Paul, Fiorentini, Francesco, Poggesi, Italo, Jannuzzo, M. Gabriella, Fleishaker, Joseph C., Houin, Georges, Duchêne, Patrick

“…Reboxetine is a new selective norepinephrine reuptake inhibitor (selective NRI) for the short‐ and long‐term treatment of depression that is effective and well…”
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Gender does not affect the degree of induction of tirilazad clearance by phenobarbital by FLEISHAKER, J. C, PEARSON, L. K, PETERS, G. R

“…Tirilazad mesylate is a membrane lipid peroxidation inhibitor being evaluated for the treatment of patients with subarachnoid haemorrhage (SAH); phenobarbital…”
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Kinetic Characterization and Identification of the Enzymes Responsible for the Hepatic Biotransformation of Adinazolam and N-Desmethyladinazolam in Man by Venkatakrishnan, Karthik, Von Moltke, Lisa L., Duan, Su Xiang, Fleishaker, Joseph C., Shader, Richard I., Greenblatt, David J.

“…The kinetics of the N‐demethylation of adinazolam to N‐desmethyladinazolam (NDMAD), and of NDMAD to didesmethyladinazolam (DDMAD), were studied with human…”
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Absolute bioavailability of reboxetine enantiomers and effect of gender on pharmacokinetics by Fleishaker, Joseph C., Mucci, Massimiliano, Pellizzoni, Cinzia, Poggesi, Italo

“…The absolute bioavailability of reboxetine enantiomers was assessed in six male and six female volunteers. In a two‐way crossover study, subjects received 1.0…”
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Effect of age and gender on tirilazad pharmacokinetics in humans by Hulst, L K, Fleishaker, J C, Peters, G R, Harry, J D, Wright, D M, Ward, P

“…Tirilazad mesylate pharmacokinetics were assessed in 12 young and 12 elderly volunteers (six men and six women per age group). Subjects received single…”
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Population pharmacokinetics of tirilazad : Effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage by FLEISHAKER, J. C, FIEDLER-KELLY, J, GRASELA, T. H

“…Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which…”
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Pharmacokinetics of reboxetine in healthy, elderly volunteers by BERGMANN, J. F, LANEURY, J. P, DUCHENE, P, FLEISHAKER, J. C, HOUIN, G, SEGRESTAA, J-M

“…The pharmacokinetic characteristics of reboxetine, a unique selective noradrenaline reuptake inhibitor (selective NRI) for the treatment of depression, were…”
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Comparison of the spectrum of cognitive effects of alprazolam and adinazolam after single doses in healthy subjects by FLEISHAKER, J. C, GARZONE, P. D, CHAMBERS, J. H, SIROCCO, K, WEINGARTNER, H

“…Single doses of alprazolam (0, 0.5, 1.5 mg) or adinazolam mesylate sustained release tablets (SR) (0, 15, 45 mg) were administered to separate groups of 12…”
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