Search Results - "FLAVENY, Colin A"

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis by Flaveny, Colin A., Griffett, Kristine, El-Gendy, Bahaa El-Dien M., Kazantzis, Melissa, Sengupta, Monideepa, Amelio, Antonio L., Chatterjee, Arindam, Walker, John, Solt, Laura A., Kamenecka, Theodore M., Burris, Thomas P.

“…Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance…”
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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells by Boitano, Anthony E, Wang, Jian, Romeo, Russell, Bouchez, Laure C, Parker, Albert E, Sutton, Sue E, Walker, John R, Flaveny, Colin A, Perdew, Gary H, Denison, Michael S, Schultz, Peter G, Cooke, Michael P

“…Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells…”
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Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis by Schaub, Franz X, Reza, Md Shamim, Flaveny, Colin A, Li, Weimin, Musicant, Adele M, Hoxha, Sany, Guo, Min, Cleveland, John L, Amelio, Antonio L

“…Fluorescent proteins are widely used to study molecular and cellular events, yet this traditionally relies on delivery of excitation light, which can trigger…”
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Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice by Welch, Ryan D, Billon, Cyrielle, Kameric, Amina, Burris, Thomas P, Flaveny, Colin A

“…Numerous mutational studies have demonstrated that circadian clock proteins regulate behavior and metabolism. Nr1d1(Rev-erbα) is a key regulator of circadian…”
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The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor by Schroeder, Jennifer C, DiNatale, Brett C, Murray, Iain A, Flaveny, Colin A, Liu, Qiang, Laurenzana, Elizabeth M, Lin, Jyh Ming, Strom, Stephen C, Omiecinski, Curtis J, Amin, Shantu, Perdew, Gary H

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in the regulation of multiple cellular pathways, such as xenobiotic…”
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Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis by Li, Bin, Flaveny, Colin A, Giambelli, Camilla, Fei, Dennis Liang, Han, Lu, Hang, Brian I, Bai, Feng, Pei, Xin-Hai, Nose, Vania, Burlingame, Oname, Capobianco, Anthony J, Orton, Darren, Lee, Ethan, Robbins, David J

“…Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated…”
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A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis by Sengupta, Monideepa, Abuirqeba, Suomia, Kameric, Amina, Cecile-Valfort, Aurore, Chatterjee, Arindam, Griffett, Kristine, Burris, Thomas P, Flaveny, Colin A

“…Alcoholic liver disease (ALD) is responsible for an average of 50.4% and 44.2%of liver disease deaths among males and females respectively. Driven by alcohol…”
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International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023 by Burris, Thomas P, de Vera, Ian Mitchelle S, Cote, Isabelle, Flaveny, Colin A, Wanninayake, Udayanga S, Chatterjee, Arindam, Walker, John K, Steinauer, Nickolas, Zhang, Jinsong, Coons, Laurel A, Korach, Kenneth S, Cain, Derek W, Hollenberg, Anthony N, Webb, Paul, Forrest, Douglas, Jetten, Anton M, Edwards, Dean P, Grimm, Sandra L, Hartig, Sean, Lange, Carol A, Richer, Jennifer K, Sartorius, Carol A, Tetel, Marc, Billon, Cyrielle, Elgendy, Bahaa, Hegazy, Lamees, Griffett, Kristine, Peinetti, Nahuel, Burnstein, Kerry L, Hughes, Travis S, Sitaula, Sadichha, Stayrook, Keitch R, Culver, Alexander, Murray, Meghan H, Finck, Brian N, Cidlowski, John A

“…The NR superfamily comprises 48 transcription factors in humans that control a plethora of gene network programs involved in a wide range of physiologic…”
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Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice by Flaveny, Colin A, Murray, Iain A, Chiaro, Chris R, Perdew, Gary H

“…The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that displays interspecies differences with the human and mouse AHR C-terminal…”
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Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened by BIN LI, LIANG FEI, Dennis, ORTON, Darren, LU HAN, BAOLIN WANG, CAPOBIANCO, Anthony J, ETHAN LEE, ROBBINS, David J, FLAVENY, Colin A, DAHMANE, Nadia, BAUBET, Valérie, ZHIQIANG WANG, FENG BAI, PEI, Xin-Hai, RODRIGUEZ-BIANCO, Jezabel, BRIAN HANG

“…The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a…”
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Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity by Murray, Iain A, Morales, Jose L, Flaveny, Colin A, Dinatale, Brett C, Chiaro, Chris, Gowdahalli, Krishnegowda, Amin, Shantu, Perdew, Gary H

“…The concept of selective receptor modulators has been established for the nuclear steroid hormone receptors. Such selective modulators have been used…”
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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition by Musicant, Adele M., Parag-Sharma, Kshitij, Gong, Weida, Sengupta, Monideepa, Chatterjee, Arindam, Henry, Erin C., Tsai, Yi-Hsuan, Hayward, Michele C., Sheth, Siddharth, Betancourt, Renee, Hackman, Trevor G., Padilla, Ricardo J., Parker, Joel S., Giudice, Jimena, Flaveny, Colin A., Hayes, David N., Amelio, Antonio L.

“…Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic…”
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The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis by Griffett, Kristine, Welch, Ryan D, Flaveny, Colin A, Kolar, Grant R, Neuschwander-Tetri, Brent A, Burris, Thomas P

“…Abstract Objective Non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis, inflammation and fibrosis. There are currently no targeted…”
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Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone by Murray, Iain A, Flaveny, Colin A, DiNatale, Brett C, Chairo, Chris R, Schroeder, Jennifer C, Kusnadi, Ann, Perdew, Gary H

“…The aryl hydrocarbon receptor (AHR) is regarded as an important homeostatic transcriptional regulator within physiological and pathophysiological processes,…”
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Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome by Welch, Ryan D, Guo, Chun, Sengupta, Monideepa, Carpenter, Katherine J, Stephens, Natalie A, Arnett, Stacy A, Meyers, Marvin J, Sparks, Lauren M, Smith, Steven R, Zhang, Jinsong, Burris, Thomas P, Flaveny, Colin A

“…Abstract Objective The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately,…”
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Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling by DiNatale, Brett C., Murray, Iain A., Schroeder, Jennifer C., Flaveny, Colin A., Lahoti, Tejas S., Laurenzana, Elizabeth M., Omiecinski, Curtis J., Perdew, Gary H.

“…Inflammatory signaling plays a key role in tumor progression, and the pleiotropic cytokine interleukin-6 (IL-6) is an important mediator of protumorigenic…”
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LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer by Carpenter, Katherine J., Valfort, Aurore-Cecile, Steinauer, Nick, Chatterjee, Arindam, Abuirqeba, Suomia, Majidi, Shabnam, Sengupta, Monideepa, Di Paolo, Richard J., Shornick, Laurie P., Zhang, Jinsong, Flaveny, Colin A.

“…Triple-negative breast cancer (TNBC) is a highly aggressive subtype that is untreatable with hormonal or HER2-targeted therapies and is also typically…”
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Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model by Johnson, David, Tobo, Connor, Au, Jeffrey, Nagarapu, Aakash, Ziemkiewicz, Natalia, Chauvin, Hannah, Robinson, Jessica, Shringarpure, Saloni, Tadiwala, Jamshid, Brockhouse, Julia, Flaveny, Colin A., Garg, Koyal

“…Volumetric muscle loss (VML) injury causes irreversible deficits in muscle mass and function, often resulting in permanent disability. The current standard of…”
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Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor by Flaveny, Colin A., Murray, Iain A., Perdew, Gary H.

“…The human aryl hydrocarbon receptor (hAHR) and mouse aryl hydrocarbon receptor (mAHRb) share limited (58%) transactivation domain (TAD) sequence identity…”
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Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle by Welch, Ryan D., Billon, Cyrielle, Valfort, Aurore-Cecile, Burris, Thomas P., Flaveny, Colin A.

“…Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin…”
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