Search Results - "FLAMMINI, Lisa"

Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines by La Monica, Silvia, Cretella, Daniele, Bonelli, Mara, Fumarola, Claudia, Cavazzoni, Andrea, Digiacomo, Graziana, Flammini, Lisa, Barocelli, Elisabetta, Minari, Roberta, Naldi, Nadia, Petronini, Pier Giorgio, Tiseo, Marcello, Alfieri, Roberta

“…Osimertinib is a third-generation EGFR-TKI with a high selective potency against T790M-mutant NSCLC patients. Considering that osimertinib can lead to enhanced…”
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Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models by La Monica, Silvia, Vacondio, Federica, Eltayeb, Kamal, Lodola, Alessio, Volta, Francesco, Viglioli, Martina, Ferlenghi, Francesca, Galvani, Francesca, Galetti, Maricla, Bonelli, Mara, Fumarola, Claudia, Cavazzoni, Andrea, Flammini, Lisa, Verzè, Michela, Minari, Roberta, Petronini, Pier Giorgio, Tiseo, Marcello, Mor, Marco, Alfieri, Roberta

“…The EGFR tyrosine kinase inhibitor osimertinib has been approved for the first-line treatment of EGFR -mutated Non-Small Cell Lung Cancer (NSCLC) patients…”
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Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC by La Monica, Silvia, Minari, Roberta, Cretella, Daniele, Flammini, Lisa, Fumarola, Claudia, Bonelli, Mara, Cavazzoni, Andrea, Digiacomo, Graziana, Galetti, Maricla, Madeddu, Denise, Falco, Angela, Lagrasta, Costanza Annamaria, Squadrilli, Anna, Barocelli, Elisabetta, Romanel, Alessandro, Quaini, Federico, Petronini, Pier Giorgio, Tiseo, Marcello, Alfieri, Roberta

“…The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive…”
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Micro-fragmented Fat Inhibits the Progression of Human Mesothelioma Xenografts in Mice by La Monica, Silvia, Coccé, Valentina, Bonelli, Mara, Alessandri, Giulio, Alfieri, Roberta, Lagrasta, Costanza Annamaria, Frati, Caterina, Flammini, Lisa, Gianni, Aldo, Petrella, Francesco, Paino, Francesca, Pessina, Augusto

“…Malignant pleural mesothelioma is a pathology with no effective therapy and a poor prognosis. Our previous study demonstrated an in vitro inhibitory effect on…”
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Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation by Giorgio, Carmine, Hassan Mohamed, Iftiin, Flammini, Lisa, Barocelli, Elisabetta, Incerti, Matteo, Lodola, Alessio, Tognolini, Massimiliano

“…Eph-ephrin system plays a central role in a large variety of human cancers. In fact, alterated expression and/or de-regulated function of Eph-ephrin system…”
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α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way by Grandi, Andrea, Zini, Irene, Flammini, Lisa, Cantoni, Anna M., Vivo, Valentina, Ballabeni, Vigilio, Barocelli, Elisabetta, Bertoni, Simona

“…The existence of a cholinergic anti-inflammatory pathway negatively modulating the inflammatory and immune responses in various clinical conditions and…”
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Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats by Vacondio, Federica, Bassi, Michele, Silva, Claudia, Castelli, Riccardo, Carmi, Caterina, Scalvini, Laura, Lodola, Alessio, Vivo, Valentina, Flammini, Lisa, Barocelli, Elisabetta, Mor, Marco, Rivara, Silvia

“…Palmitoylethanolamide (PEA) has antinflammatory and antinociceptive properties widely exploited in veterinary and human medicine, despite its poor…”
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Targeting the Eph/Ephrin System as Anti-Inflammatory Strategy in IBD by Grandi, Andrea, Zini, Irene, Palese, Simone, Giorgio, Carmine, Tognolini, Massimiliano, Marchesani, Francesco, Bruno, Stefano, Flammini, Lisa, Cantoni, Anna Maria, Castelli, Riccardo, Lodola, Alessio, Fusari, Antonella, Barocelli, Elisabetta, Bertoni, Simona

“…Besides their long-known critical role in embryonic growth and in cancer development and progression, erythropoietin-producing hepatocellular carcinoma type B…”
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An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro by D'Angelo, Davide, Quarta, Eride, Glieca, Stefania, Varacca, Giada, Flammini, Lisa, Bertoni, Simona, Brandolini, Martina, Sambri, Vittorio, Grumiro, Laura, Gatti, Giulia, Dirani, Giorgio, Taddei, Francesca, Bianchera, Annalisa, Sonvico, Fabio, Bettini, Ruggero, Buttini, Francesca

“…This work illustrates the development of a dry inhalation powder of cyclosporine-A for the prevention of rejection after lung transplantation and for the…”
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UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling by Giorgio, Carmine, Allodi, Marika, Palese, Simone, Grandi, Andrea, Tognolini, Massimiliano, Castelli, Riccardo, Lodola, Alessio, Flammini, Lisa, Cantoni, Anna Maria, Barocelli, Elisabetta, Bertoni, Simona

“…Eph receptors, comprising A and B classes, interact with cell-bound ephrins generating bidirectional signaling. Although mainly related to carcinogenesis and…”
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Development and validation of a DESI-HRMS/MS method for the fast profiling of esomeprazole and its metabolites in rat plasma: a pharmacokinetic study by Rossi, Alessandra, Castrati, Luca, Colombo, Paolo, Flammini, Lisa, Barocelli, Elisabetta, Bettini, Ruggero, Elviri, Lisa

“…The advances in pharmaceutical development and drug discovery impose the availability of reliable high‐throughput screening methods for the rapid evaluation of…”
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Inhibition of Human Malignant Pleural Mesothelioma Growth by Mesenchymal Stromal Cells by Coccè, Valentina, La Monica, Silvia, Bonelli, Mara, Alessandri, Giulio, Alfieri, Roberta, Lagrasta, Costanza Annamaria, Madeddu, Denise, Frati, Caterina, Flammini, Lisa, Lisini, Daniela, Marcianti, Angela, Parati, Eugenio, Paino, Francesca, Giannì, Aldo, Farronato, Giampietro, Falco, Angela, Spaggiari, Lorenzo, Petrella, Francesco, Pessina, Augusto

“…Background: Malignant Pleural Mesothelioma (MPM) is an aggressive tumor that has a significant incidence related to asbestos exposure with no effective therapy…”
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Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands by Pala, Daniele, Scalvini, Laura, Lodola, Alessio, Mor, Marco, Flammini, Lisa, Barocelli, Elisabetta, Lucini, Valeria, Scaglione, Francesco, Bartolucci, Silvia, Bedini, Annalida, Rivara, Silvia, Spadoni, Gilberto

“…Melatonin is an endogenous molecule involved in many pathophysiological processes. In addition to the control of circadian rhythms, its antioxidant and…”
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Rifaximin anti‐inflammatory activity on bovine endometrium primary cell cultures: a preliminary study by Flammini, Lisa, Mantelli, Leonardo, Volpe, Alessandra, Domenichini, Giuseppe, Di Lecce, Rosanna, Dondi, Maurizio, Cantoni, Anna Maria, Barocelli, Elisabetta, Quintavalla, Fausto

“…Rifaximin is an unabsorbed oral antibiotic showing anti‐inflammatory properties in human pathologies like irritable bowel syndrome and inflammatory bowel…”
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3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats by Intini, Claudio, Elviri, Lisa, Cabral, Jaydee, Mros, Sonya, Bergonzi, Carlo, Bianchera, Annalisa, Flammini, Lisa, Govoni, Paolo, Barocelli, Elisabetta, Bettini, Ruggero, McConnell, Michelle

“…•Microstructure conferred by 3D printing is critical for cell growth on chitosan scaffolds.•Demonstration of biocompatibility of 3D printed chitosan…”
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Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis by Allodi, Marika, Giorgio, Carmine, Incerti, Matteo, Corradi, Domenico, Flammini, Lisa, Ballabeni, Vigilio, Barocelli, Elisabetta, Radi, Marco, Bertoni, Simona

“…Concerning the growing interest in the role played by the CCL20/CCR6 axis in IBD pathogenesis and in the search for novel anti-IBD small molecules, we have…”
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Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa by Glieca, Stefania, Quarta, Eride, Bottari, Benedetta, Bancalari, Elena, Monica, Saverio, Scaltriti, Erika, Tambassi, Martina, Flammini, Lisa, Bertoni, Simona, Bianchera, Annalisa, Fainardi, Valentina, Esposito, Susanna, Pisi, Giovanna, Bettini, Ruggero, Sonvico, Fabio, Buttini, Francesca

“…The aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plantarum [Lpb. plantarum], Lacticaseibacillus…”
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Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats by Quarta, Eride, Chierici, Veronica, Flammini, Lisa, Tognolini, Massimiliano, Barocelli, Elisabetta, Cantoni, Anna Maria, Dujovny, Gabriela, Ecenarro Probst, Susana, Sonvico, Fabio, Colombo, Gaia, Rossi, Alessandra, Bettini, Ruggero, Colombo, Paolo, Buttini, Francesca

“…A novel pure insulin spray-dried powder for DPI product (Ins_SD) was studied with respect to physico-chemical stability, in vitro respirability,…”
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Novel analgesic agents obtained by molecular hybridization of orthosteric and allosteric ligands by Matera, Carlo, Flammini, Lisa, Riefolo, Fabio, Domenichini, Giuseppe, De Amici, Marco, Barocelli, Elisabetta, Dallanoce, Clelia, Bertoni, Simona

“…Despite the high incidence of acute and chronic pain in the general population, the efficacy of currently available medications is unsatisfactory. Insufficient…”
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Su1816 – Protection by Ccr6 Blockade in a Murine Model of Crohn’s Disease by Palese, Simone, Giorgio, Carmine, Radi, Marco, Grandi, Andrea, Flammini, Lisa, Ballabeni, Vigilio, Barocelli, Elisabetta, Bertoni, Simona

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