Search Results - "FLAKE, Gordon"

Pathology of Diacetyl and 2,3-Pentanedione Airway Lesions in a Rat Model of Obliterative Bronchiolitis by Flake, Gordon P, Morgan, Daniel L

“…Abstract Inhalation of diacetyl vapors by workers has been associated with obliterative bronchiolitis (OB), a poorly understood fibroproliferative disease of…”
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Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma by Li, Yuanyuan, Li, Melissa, Shats, Igor, Krahn, Juno M, Flake, Gordon P, Umbach, David M, Li, Xiaoling, Li, Leping

“…Due to the poor prognosis of advanced metastatic melanoma, it is crucial to find early biomarkers that help identify which melanomas will metastasize. By…”
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Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies by Patial, Sonika, Curtis, Alan D., Lai, Wi S., Stumpo, Deborah J., Hill, Georgette D., Flake, Gordon P., Mannie, Mark D., Blackshear, Perry J.

“…Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to adenylate-uridylate–rich elements (AREs) in the 3′-untranslated…”
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Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats by Palmer, Scott M, Flake, Gordon P, Kelly, Fran L, Zhang, Helen L, Nugent, Julia L, Kirby, Patrick J, Foley, Julie F, Gwinn, William M, Morgan, Dan L

“…Bronchiolitis obliterans (BO) is a fibrotic lung disease that occurs in a variety of clinical settings, including toxin exposures, autoimmunity and lung or…”
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Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver by Hori, Takeshi, Saito, Kosuke, Moore, Rick, Flake, Gordon P, Negishi, Masahiko

“…Phenobarbital, a nongenotoxic hepatocarcinogen, induces hepatic proliferation and promotes development of hepatocellular carcinoma (HCC) in rodents. Nuclear…”
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Etiology and Pathogenesis of Uterine Leiomyomas: A Review by Flake, Gordon P., Andersen, Janet, Dixon, Darlene

“…Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become…”
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Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice by Hoopes, Samantha L, Gruzdev, Artiom, Edin, Matthew L, Graves, Joan P, Bradbury, J Alyce, Flake, Gordon P, Lih, Fred B, DeGraff, Laura M, Zeldin, Darryl C

“…Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure…”
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The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens by Wilson, Rhonda H, Maruoka, Shuichiro, Whitehead, Gregory S, Foley, Julie F, Flake, Gordon P, Sever, Michelle L, Zeldin, Darryl C, Kraft, Monica, Garantziotis, Stavros, Nakano, Hideki, Cook, Donald N

“…House dust promotes allergic responses to inhaled allergens, but it remains unclear what microbial components in dust are required for this activity. Donald N…”
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Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus by Shindo, Sawako, Moore, Rick, Flake, Gordon, Negishi, Masahiko

“…Whereas estrogen receptors are present in immune cells, it is not known if they are phosphorylated to regulate immune cell functions. Here we determined the…”
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TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation by Whitehead, Gregory S, Thomas, Seddon Y, Shalaby, Karim H, Nakano, Keiko, Moran, Timothy P, Ward, James M, Flake, Gordon P, Nakano, Hideki, Cook, Donald N

“…Asthma is associated with exposure to a wide variety of allergens and adjuvants. The extent to which overlap exists between the cellular and molecular…”
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Respiratory Toxicity of Diacetyl in C57Bl/6 Mice by Morgan, Daniel L., Flake, Gordon P., Kirby, Patrick J., Palmer, Scott M.

“…Diacetyl, a component of artificial butter flavoring, is a potential etiological agent of obliterative bronchiolitis (OB); however, the toxic dose and…”
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Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice by Deng, Yangmei, Edin, Matthew L., Theken, Katherine N., Schuck, Robert N., Flake, Gordon P., Kannon, M. Alison, DeGraff, Laura M., Lih, Fred B., Foley, Julie, Bradbury, J. Alyce, Graves, Joan P., Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.

“…ABSTRACT Cytochrome P‐450 (CYP)‐derived epoxyei‐cosatrienoic acids (EETs) possess potent anti‐inflammatory effects in vitro. However, the effect of increased…”
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Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats by Morgan, Daniel L, Merrick, B Alex, Gerrish, Kevin E, Stockton, Patricia S, Wang, Yu, Foley, Julie F, Gwinn, William M, Kelly, Francine L, Palmer, Scott M, Ton, Thai-Vu T, Flake, Gordon P

“…Obliterative bronchiolitis (OB) is an irreversible lung disease characterized by progressive fibrosis in the small airways with eventual occlusion of the…”
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Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation by Card, Jeffrey W, Carey, Michelle A, Bradbury, J. Alyce, DeGraff, Laura M, Morgan, Daniel L, Moorman, Michael P, Flake, Gordon P, Zeldin, Darryl C

“…The roles of gender and sex hormones in lung function and disease are complex and not completely understood. The present study examined the influence of gender…”
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Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans by Morgan, Daniel L., Jokinen, Micheal P., Price, Herman C., Gwinn, William M., Palmer, Scott M., Flake, Gordon P.

“…2,3-Pentanedione (PD) is a component of artificial butter flavorings. The use of PD is increasing since diacetyl, a major butter flavorant, was associated with…”
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Toward predicting metastatic progression of melanoma based on gene expression data by Li, Yuanyuan, Krahn, Juno M., Flake, Gordon P., Umbach, David M., Li, Leping

“…Summary Primary and metastatic melanoma tumors share the same cell origin, making it challenging to identify genomic biomarkers that can differentiate them…”
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High molecular weight hyaluronan ameliorates allergic inflammation and airway hyperresponsiveness in the mouse by Johnson, Collin G, Stober, Vandy P, Cyphert-Daly, Jaime M, Trempus, Carol S, Flake, Gordon P, Cali, Valbona, Ahmad, Israr, Midura, Ronald J, Aronica, Mark A, Matalon, Sadis, Garantziotis, Stavros

“…Allergic asthma is a major cause of morbidity in both pediatric and adult patients. Recent research has highlighted the role of hyaluronan (HA), an…”
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Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome by Patial, Sonika, Stumpo, Deborah J., Young, W. Scott, Ward, James M., Flake, Gordon P., Blackshear, Perry J.

“…Tristetraprolin (TTP) acts by binding to AU-rich elements in certain mRNAs, such as tumor necrosis factor (TNF) mRNA, and increasing their decay rates. TTP…”
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Airway injury in an in vitro human epithelium-fibroblast model of diacetyl vapor exposure: diacetyl-induced basal/suprabasal spongiosis by Gwinn, William M., Flake, Gordon P., Bousquet, Ronald W., Taylor, Genie J., Morgan, Daniel L.

“…Inhalation exposure to diacetyl (DA) is associated with obliterative bronchiolitis (OB) in workers and induces OB-like fibrotic airway lesions in rats. The…”
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Contribution of alveolar type II cell‐derived cyclooxygenase‐2 to basal airway function, lung inflammation, and lung fibrosis by Cheng, Jennifer, Dackor, Ryan T., Bradbury, J. Alyce, Li, g, DeGraff, Laura M., Hong, Lee K., King, Debra, Lih, Fred B., Gruzdev, Artiom, Edin, Matthew L., Travlos, Gregory S., Flake, Gordon P., Tomer, Kenneth B., Zeldin, Darryl C.

“…ABSTRACT Cyclooxygenase (COX)‐2 has been shown to be involved in regulating basal airway function, bacterial LPS‐induced airway hyperresponsiveness (AHR) and…”
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