Search Results - "FLAGELLA, Michael"

Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release by Su, Gui, Kintner, Douglas B, Flagella, Michael, Shull, Gary E, Sun, Dandan

“…We reported previously that inhibition of Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) by bumetanide abolishes high extracellular K(+) concentration…”
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Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf by Flagella, Michael, Clarke, Lane L., Miller, Marian L., Erway, Lawrence C., Giannella, Ralph A., Andringa, Anastasia, Gawenis, Lara R., Kramer, Jennifer, Duffy, John J., Doetschman, Thomas, Lorenz, John N., Yamoah, Ebenezer N., Cardell, Emma Lou, Shull, Gary E.

“…In chloride-secretory epithelia, the basolateral Na-K-2Cl cotransporter (NKCC1) is thought to play a major role in transepithelial Cl− and fluid transport…”
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Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter by Meyer, Jamie W, Flagella, Michael, Sutliff, Roy L, Lorenz, John N, Nieman, Michelle L, Weber, Craig S, Paul, Richard J, Shull, Gary E

“…The basolateral Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) functions in the maintenance of cellular electrolyte and volume homeostasis. NKCC1-deficient…”
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Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice by Evans, R L, Park, K, Turner, R J, Watson, G E, Nguyen, H V, Dennett, M R, Hand, A R, Flagella, M, Shull, G E, Melvin, J E

“…The salivary fluid secretory mechanism is thought to require Na(+)/K(+)/2Cl(-) cotransporter-mediated Cl(-) uptake. To directly test this possibility we…”
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Mouse Mammary Epithelial Cells Express the Na-K-Cl Cotransporter, NKCC1: Characterization, Localization, and Involvement in Ductal Development and Morphogenesis by Shillingford, Jonathan M, Miyoshi, Keiko, Flagella, Michael, Shull, Gary E, Hennighausen, Lothar

“…Despite the fact that physiological evidence points to the existence of a functional Na-K-Cl cotransporter in the mammary gland, the molecular identity of this…”
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An alternate pathway of cAMP-stimulated Cl− secretion across the NKCC1-null murine duodenum by Walker, Nancy M., Flagella, Michael, Gawenis, Lara R., Shull, Gary E., Clarke, Lane L.

“…Background & Aims: Adenosine 3',5'-cyclic monophosphate (cAMP)-stimulated anion secretion across the duodenal epithelium requires the cystic fibrosis…”
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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung by Fuji, Reina N, Flagella, Michael, Baca, Miriam, Baptista, Marco A S, Brodbeck, Jens, Chan, Bryan K, Fiske, Brian K, Honigberg, Lee, Jubb, Adrian M, Katavolos, Paula, Lee, Donna W, Lewin-Koh, Sock-Cheng, Lin, Tori, Liu, Xingrong, Liu, Shannon, Lyssikatos, Joseph P, O'Mahony, Jennifer, Reichelt, Mike, Roose-Girma, Merone, Sheng, Zejuan, Sherer, Todd, Smith, Ashley, Solon, Margaret, Sweeney, Zachary K, Tarrant, Jacqueline, Urkowitz, Alison, Warming, Søren, Yaylaoglu, Murat, Zhang, Shuo, Zhu, Haitao, Estrada, Anthony A, Watts, Ryan J

“…Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However,…”
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Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors by Estrada, Anthony A, Chan, Bryan K, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chen, Huifen, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Fuji, Reina, Gill, Andrew, Halladay, Jason, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Pichon, Claire E. Le, Liu, Xingrong, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Wong, Susan, Zhang, Shuo, Zhang, Xiaolin, Zhu, Haitao, Sweeney, Zachary K

“…Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for…”
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An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines by DAVIDSON, Jennifer D, LIANDONG MA, FLAGELLA, Michael, GEEGANAGE, Sandaruwan, GELBERT, Lawrence M, SLAPAK, Christopher A

“…The mechanisms of resistance to the antimetabolite gemcitabine in non-small cell lung cancer have not been extensively evaluated. In this study, we report the…”
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Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta by Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P

“…Inhibition of PI3Kδ is considered to be an attractive mechanism for the treatment of inflammatory diseases and leukocyte malignancies. Using a structure-based…”
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Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1 by Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva

“…Checkpoint kinase 1 (ChK1) plays a key role in the DNA damage response, facilitating cell-cycle arrest to provide sufficient time for lesion repair. This leads…”
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Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900 by Blackwood, Elizabeth, Epler, Jennifer, Yen, Ivana, Flagella, Michael, O'Brien, Tom, Evangelista, Marie, Schmidt, Stephen, Xiao, Yang, Choi, Jonathan, Kowanetz, Kaska, Ramiscal, Judi, Wong, Kenton, Jakubiak, Diana, Yee, Sharon, Cain, Gary, Gazzard, Lewis, Williams, Karen, Halladay, Jason, Jackson, Peter K, Malek, Shiva

“…Checkpoint kinase 1 (ChK1) is a serine/threonine kinase that functions as a central mediator of the intra-S and G2-M cell-cycle checkpoints. Following DNA…”
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Abstract 1598: RM-046, a first-in-class, mutant-selective, and oral KRASQ61H(ON) inhibitor that drives tumor regression in preclinical models and validates KRASQ61H as a therapeutic target by Yang, Yu C., Thompson, Severin, Montgomery, David, Quiñones, Antonio J., Wei, Xing, Madej, Benjamin, Tomlinson, Aidan, Shifrin, Nataliya T., McNamara, Alexander, Ahler, Ethan, McDowell, Laura L., Flagella, Michael, Setser, John, Chang, Stephanie, Wang, Zhican, Wang, Zhengping, Huang, Jun, Ballmer, Steve, li, Shaong, Buckl, Andreas, Koltun, Elena, Gill, Adrian, Jiang, Jingjing, Singh, Mallika, Smith, Jacqueline A.

“…KRASQ61H mutant cancers represent a significant unmet medical need and include common solid tumor histotypes such as non-small cell lung cancer (NSCLC),…”
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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity by Safina, Brian S., Sweeney, Zachary K., Li, Jun, Chan, Bryan K., Bisconte, Angelina, Carrera, Diane, Castanedo, Georgette, Flagella, Michael, Heald, Robert, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Pang, Jodie, Price, Steve, Reif, Karin, Salphati, Laurent, Seward, Eileen M., Wei, Binqing, Sutherlin, Daniel P.

“…In an effort to identify potent and isoform selective inhibitors of PI3Kδ, GNE-293 (34) was identified. Inhibitor 2 was found to induce micronuclei formation…”
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A multiplex branched DNA assay for parallel quantitative gene expression profiling by Flagella, Michael, Bui, Son, Zheng, Zhi, Nguyen, Cung Tuong, Zhang, Aiguo, Pastor, Larry, Ma, Yunqing, Yang, Wen, Crawford, Kimberly L., McMaster, Gary K., Witney, Frank, Luo, Yuling

“…We describe a novel method to quantitatively measure messenger RNA (mRNA) expression of multiple genes directly from crude cell lysates and tissue homogenates…”
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Identification of GNE-293, a potent and selective PI3KI' inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity by Safina, Brian, Sweeney, Zachary, Li, Jun, Chan, Bryan, Bisconte, Angelina, Carrera, Diane, Castanedo, Georgette, Flagella, Michael, Heald, Robert, Lewis, Cristina, Murray, Jeremy, Nonomiya, Jim, Pang, Jodie, Price, Steve, Reif, Karin, Salphati, Laurent, Seward, Eileen, Wei, Binqing, Sutherlin, Daniel

“…In an effort to identify potent and isoform selective inhibitors of PI3KI', GNE-293 (34) was identified. Inhibitor 2 was found to induce micronuclei formation…”
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Phenotype Resembling Gitelman's Syndrome in Mice Lacking the Apical Na+-Cl− Cotransporter of the Distal Convoluted Tubule by Schultheis, Patrick J., Lorenz, John N., Meneton, Pierre, Nieman, Michelle L., Riddle, Tara M., Flagella, Michael, Duffy, John J., Doetschman, Thomas, Miller, Marian L., Shull, Gary E.

“…Mutations in the gene encoding the thiazide-sensitive Na+-Cl− cotransporter (NCC) of the distal convoluted tubule cause Gitelman's syndrome, an inherited…”
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Exploratory cardiovascular safety pharmacology in the lead-optimization of novel small molecule kinase inhibitors by Flagella, Michael, Gazzard, Lewis, Halladay, Jason, Yokogawa, Ryan, Wong, Lisa, Lubach, Joe, Blackwood, Beth, Malek, Shiva, Dambach, Donna

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Small interfering RNA and gene expression analysis using a multiplex branched DNA assay without RNA purification by Zhang, Aiguo, Pastor, Larry, Nguyen, Quan, Luo, Yuling, Yang, Wen, Flagella, Michael, Chavli, Rajesh, Bui, Son, Nguyen, Cung Tuong, Zheng, Zhi, He, Weihai, McMaster, Gary, Witney, Frank

“…The authors have developed a novel multiplex detection system that quantitatively measures the expression level of 11 messenger RNAs (mRNAs) directly from cell…”
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Cloning, renal distribution, and regulation of the rat Na+-HCO3- cotransporter by Burnham, C E, Flagella, M, Wang, Z, Amlal, H, Shull, G E, Soleimani, M

“…We recently reported the cloning and expression of a human kidney Na+-HCO3- cotransporter (NBC-1) (C. E. Burnham, H. Amlal, Z. Wang, G. E. Shull, and M…”
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