Search Results - "FITZSIMMONS, Sara A"

A Mortality Gene(s) for the Human Adenocarcinoma Line HeLa Maps to a 130-kb Region of Human Chromosome 4q22-q23 by Bryce, Steven D., Morrison, Vivienne, Craig, Nicola J., Forsyth, Nicholas R., Fitzsimmons, Sara A., Ireland, Hazel, Cuthbert, Andrew P., Newbold, Robert F., Parkinson, E. Kenneth

“…Human chromosome 4 was previously shown to elicit features of senescence when introduced into cell lines that map to complementation group B for senescence,…”
Get full text

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9 by Fitzsimmons, Sara A., Workman, Paul, Grever, Michael, Paull, Kenneth, Camalier, Richard, Lewis, Alexander D.

“…Background Many antitumor drugs require metabolic activation to exert their cytotoxic or cytostatic effects. The socalled bioreductive compounds, whose…”
Get full text

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors by Rampling, R, Cruickshank, G, Lewis, A D, Fitzsimmons, S A, Workman, P

“…To measure the oxygen status of human malignant brain tumors in vivo and to determine the activities and expression of bioreductive enzymes in these same human…”
Get more information

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4 by FORSYTH, Nicholas R, MORRISON, Vivienne, BRYCE, Steven D, PARKINSON, E. Kenneth, CRAIG, Nicola J, FITZSIMMONS, Sara A, BARR, Nighean I, IRELAND, Hazel, GORDON, Katrina E, DOWEN, Sally, CUTHBERT, Andrew P, NEWBOLD, Robert F

“…Squamous cell carcinoma (SCC) immortality is associated with p53 and INK4A dysfunction, high levels of telomerase and loss of heterozygosity (LOH) of other…”
Get full text

Response by Workman, Paul, Fitzsimmons, Sara A, Grever, Michael, Paull, Kenneth

“…Workman and others respond to Chris Pritsos' questions about their study of the potential value of a comprehensive analysis of reductase activities in a broad…”
Get full text

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene by BRYCE, S. D, FORSYTH, N. R, FITZSIMMONS, S. A, CLARK, L. J, BERTRAM, M. J, CUTHBERT, A. P, NEWBOLD, R. F, PEREIRA-SMITH, O. M, PARKINSON, E. K

“…Approximately 50% of immortal human keratinocyte lines show loss of heterozygosity of chromosome region 4q33-q34, and the reintroduction of chromosome 4 into…”
Get full text

Re: Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9 by WORKMAN, PAUL, FITZSIMMONS, SARA A., GREVER, MICHAEL, PAULL, KENNETH, CAMALIER, RICHARD, LEWIS, ALEXANDER D.

Get full text