Search Results - "FITZPATRICK, John M"

Taxane Mechanisms of Action: Potential Implications for Treatment Sequencing in Metastatic Castration-resistant Prostate Cancer by Fitzpatrick, John M, de Wit, Ronald

“…Abstract Context In the past few years, there has been a rapid increase in the number of therapies available to treat metastatic castration-resistant prostate…”
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Management of prostate cancer in older patients: updated recommendations of a working group of the International Society of Geriatric Oncology by Droz, Jean-Pierre, Prof, Aapro, Matti, MD, Balducci, Lodovico, MD, Boyle, Helen, MD, Van den Broeck, Thomas, MD, Cathcart, Paul, FRCS, Dickinson, Louise, MRCS, Efstathiou, Eleni, MD, Emberton, Mark, MD, Fitzpatrick, John M, MCh, Heidenreich, Axel, MD, Hughes, Simon, FRCR, Joniau, Steven, MD, Kattan, Michael, PhD, Mottet, Nicolas, MD, Oudard, Stéphane, MD, Payne, Heather, FRCR, Saad, Fred, MD, Sugihara, Toru, MD

“…Summary In 2010, the International Society of Geriatric Oncology (SIOG) developed treatment guidelines for men with prostate cancer who are older than 70 years…”
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Epidemiology of testicular cancer by Manecksha, Rustom P., Fitzpatrick, John M.

“…Testicular cancer is of interest and importance because its incidence has been increasing in most countries over the past four decades. Although it remains an…”
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Optimal management of metastatic castration-resistant prostate cancer: Highlights from a European Expert Consensus Panel by Fitzpatrick, John M, Bellmunt, Joaquim, Fizazi, Karim, Heidenreich, Axel, Sternberg, Cora N, Tombal, Bertrand, Alcaraz, Antonio, Bahl, Amit, Bracarda, Sergio, Di Lorenzo, Giuseppe, Efstathiou, Eleni, Finn, Stephen P, Fosså, Sophie, Gillessen, Silke, Kellokumpu-Lehtinen, Pirkko-Liisa, Lecouvet, Frédéric E, Oudard, Stephane, de Reijke, Theo M, Robson, Craig N, De Santis, Maria, Seruga, Bostjan, de Wit, Ronald

“…Abstract The exponential growth of novel therapies for the treatment of metastatic castration-resistant prostate cancer (mCRPC) over the last decade has…”
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Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology by Droz, Jean‐Pierre, Balducci, Lodovico, Bolla, Michel, Emberton, Mark, Fitzpatrick, John M., Joniau, Steven, Kattan, Michael W., Monfardini, Silvio, Moul, Judd W., Naeim, Arash, van Poppel, Hendrik, Saad, Fred, Sternberg, Cora N.

“…Prostate cancer is the most prevalent cancer in men and predominantly affects older men (aged ≥70 years). The median age at diagnosis is 68 years; overall,…”
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Characterisation and manipulation of docetaxel resistant prostate cancer cell lines by O'Neill, Amanda J, Prencipe, Maria, Dowling, Catherine, Fan, Yue, Mulrane, Laoighse, Gallagher, William M, O'Connor, Darran, O'Connor, Robert, Devery, Aoife, Corcoran, Claire, Rani, Sweta, O'Driscoll, Lorraine, Fitzpatrick, John M, Watson, R William G

“…There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere®) represents the most active…”
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Urologists and oncologists: adapting to a new treatment paradigm in castration‐resistant prostate cancer (CRPC) by Sartor, A. Oliver, Fitzpatrick, John M.

“…What's known on the subject? and What does the study add? The interplay between urologists and oncologists in the treatment of prostate cancer has been long…”
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The increasing incidence of mumps orchitis: a comprehensive review by Davis, Niall F., McGuire, Barry B., Mahon, Jackie A., Smyth, Anna E., O’Malley, Kiaran J., Fitzpatrick, John M.

“…There has been a recent increase in mumps orchitis among pubertal and postpubertal males. These outbreaks can be attributed to a reduction in the uptake of…”
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Enzalutamide: targeting the androgen signalling pathway in metastatic castration‐resistant prostate cancer by Schalken, Jack, Fitzpatrick, John M.

“…Significant progress has been made in the understanding of the underlying cancer biology of castration‐resistant prostate cancer (CRPC) with the androgen…”
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Investigating the role of the IGF axis as a predictor of biochemical recurrence in prostate cancer patients post‐surgery by Breen, Kieran J., O'Neill, Amanda, Murphy, Lisa, Fan, Yue, Boyce, Susie, Fitzgerald, Noel, Dorris, Emma, Brady, Lauren, Finn, Stephen P., Hayes, Brian D., Treacy, Ann, Barrett, Ciara, Aziz, Mardiana Abdul, Kay, Elaine W., Fitzpatrick, John M., Watson, R. William G.

“…Background Between 20% and 35% of prostate cancer (PCa) patients who undergo treatment with curative intent (ie, surgery or radiation therapy) for localized…”
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2D-DIGE as a Strategy To Identify Serum Markers for the Progression of Prostate Cancer by Byrne, Jennifer C, Downes, Michelle R, O’Donoghue, Niaobh, O’Keane, Conor, O’Neill, Amanda, Fan, Yue, Fitzpatrick, John M, Dunn, Michael J, Watson, R. William G

“…Prostate cancer is the most common solid organ malignancy affecting men in the United States and Western Europe. Currently, the main diagnostic tools used to…”
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Background for the proposal of SIOG guidelines for the management of prostate cancer in senior adults by Droz, Jean-Pierre, Balducci, Lodovico, Bolla, Michel, Emberton, Mark, Fitzpatrick, John M, Joniau, Steven, Kattan, Michael W, Monfardini, Silvio, Moul, Judd W, Naeim, Arash, van Poppel, Hendrik, Saad, Fred, Sternberg, Cora N

“…Abstract Background The incidence of prostate cancer increases with age, with a median age at diagnosis of 68 years. Owing to increased life expectancy, the…”
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Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms by Gill, Catherine, Walsh, Sinead E., Morrissey, Colm, Fitzpatrick, John M., Watson, R. William G.

“…BACKGROUND A critical factor in prostate cancer development and progression is the altered expression of apoptotic regulatory proteins which renders cells…”
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Progression of benign prostatic hyperplasia: systematic review of the placebo arms of clinical trials by Emberton, Mark, Fitzpatrick, John M., Garcia‐Losa, Manuel, Qizilbash, Nawab, Djavan, Bob

“…OBJECTIVE To systematically review the placebo arms of randomized trials of medical therapy for benign prostatic hyperplasia (BPH) and thus estimate rates of…”
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Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone by Molloy, Eleanor J., O’Neill, Amanda J., Grantham, Julie J., Sheridan-Pereira, Margaret, Fitzpatrick, John M., Webb, David W., Watson, R. William G.

“…Women are conferred with greater immunologic and survival benefits compared to men. Female sex steroids contribute to this sexual dimorphism. Furthermore,…”
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Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction by Quinlan, Mark R, Docherty, Neil G, Watson, R William G, Fitzpatrick, John M

“…Tubular mechanical stretch is the key primary insult in obstructive nephropathy. This review addresses how the renal tubular epithelium senses and responds to…”
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Anesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence : A Retrospective Analysis by BIKI, Barbara, MASCHA, Edward, MORIARTY, Denis C, FITZPATRICK, John M, SESSLER, Daniel I, BUGGY, Donal J

“…Regional anesthesia and analgesia attenuate or prevent perioperative factors that favor minimal residual disease after removal of the primary carcinoma…”
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Hypoxia increases normal prostate epithelial cell resistance to receptor‐mediated apoptosis via AKT activation by Walsh, Sinead, Gill, Catherine, O'Neill, Amanda, Fitzpatrick, John M., Watson, R. William G.

“…The aging prostate is associated with changes in its vascular structure, which could lead to changes in oxygen levels. Hypoxia is an important environmental…”
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Core fucosylation and α2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia by Saldova, Radka, Fan, Yue, Fitzpatrick, John M, Watson, R. William G, Rudd, Pauline M

“…One of the most urgent requirements in prostate cancer diagnosis is the development of a blood-based test which would be able to distinguish prostate cancer…”
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Caffeic acid phenethyl ester‐induced PC‐3 cell apoptosis is caspase‐dependent and mediated through the loss of inhibitors of apoptosis proteins by McEleny, Kevin, Coffey, Ronan, Morrissey, Colm, Fitzpatrick, John M., Watson, R. William G.

“…OBJECTIVE To investigate the effects of a novel agent, caffeic acid phethyl ester (CAPE) on nuclear factor (NF)‐κB activation and apoptosis in the…”
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