Search Results - "FITZGERALD, KEVIN"

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs by Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J., Madden, Thomas D., Mui, Barbara L., Semple, Sean C., Tam, Ying K., Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A., van der Meel, Roy, Cullis, Pieter R.

“…The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary…”
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A Highly Durable RNAi Therapeutic Inhibitor of PCSK9 by Fitzgerald, Kevin, White, Suellen, Borodovsky, Anna, Bettencourt, Brian R, Strahs, Andrew, Clausen, Valerie, Wijngaard, Peter, Horton, Jay D, Taubel, Jorg, Brooks, Ashley, Fernando, Chamikara, Kauffman, Robert S, Kallend, David, Vaishnaw, Akshay, Simon, Amy

“…In a phase 1 trial, healthy volunteers were assigned to an RNAi therapeutic inhibitor of PCSK9 or placebo. Single doses of 300 mg or more reduced LDL…”
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In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing by Courties, Gabriel, PhD, Heidt, Timo, MD, Sebas, Matthew, BS, Iwamoto, Yoshiko, BS, Jeon, Derrick, MS, Truelove, Jessica, BS, Tricot, Benoit, MS, Wojtkiewicz, Greg, MS, Dutta, Partha, PhD, Sager, Hendrik B., MD, Borodovsky, Anna, PhD, Novobrantseva, Tatiana, PhD, Klebanov, Boris, PhD, Fitzgerald, Kevin, PhD, Anderson, Daniel G., PhD, Libby, Peter, MD, Swirski, Filip K., PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD

“…Objectives The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages…”
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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation by Kim, Chai-Wan, Addy, Carol, Kusunoki, Jun, Anderson, Norma N., Deja, Stanislaw, Fu, Xiaorong, Burgess, Shawn C., Li, Cai, Ruddy, Marcie, Chakravarthy, Manu, Previs, Steve, Milstein, Stuart, Fitzgerald, Kevin, Kelley, David E., Horton, Jay D.

“…Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To determine if reducing lipogenesis functions similarly in humans, we…”
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An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria by Liebow, Abigail, Li, Xingsheng, Racie, Timothy, Hettinger, Julia, Bettencourt, Brian R, Najafian, Nader, Haslett, Patrick, Fitzgerald, Kevin, Holmes, Ross P, Erbe, David, Querbes, William, Knight, John

“…Primary hyperoxaluria type 1 (PH1), an inherited rare disease of glyoxylate metabolism, arises from mutations in the enzyme alanine-glyoxylate…”
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Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure by Sager, Hendrik B, Hulsmans, Maarten, Lavine, Kory J, Moreira, Marina B, Heidt, Timo, Courties, Gabriel, Sun, Yuan, Iwamoto, Yoshiko, Tricot, Benoit, Khan, Omar F, Dahlman, James E, Borodovsky, Anna, Fitzgerald, Kevin, Anderson, Daniel G, Weissleder, Ralph, Libby, Peter, Swirski, Filip K, Nahrendorf, Matthias

“…RATIONALE:Macrophages reside in the healthy myocardium, participate in ischemic heart disease and modulate myocardial infarction (MI) healing. Their origin and…”
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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape by Gilleron, Jerome, Querbes, William, Zeigerer, Anja, Borodovsky, Anna, Marsico, Giovanni, Schubert, Undine, Manygoats, Kevin, Seifert, Sarah, Andree, Cordula, Stöter, Martin, Epstein-Barash, Hila, Zhang, Ligang, Koteliansky, Victor, Fitzgerald, Kevin, Fava, Eugenio, Bickle, Marc, Kalaidzidis, Yannis, Akinc, Akin, Maier, Martin, Zerial, Marino

“…Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Delivery of short interfering…”
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Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling by Softic, Samir, Gupta, Manoj K, Wang, Guo-Xiao, Fujisaka, Shiho, O'Neill, Brian T, Rao, Tata Nageswara, Willoughby, Jennifer, Harbison, Carole, Fitzgerald, Kevin, Ilkayeva, Olga, Newgard, Christopher B, Cohen, David E, Kahn, C Ronald

“…Overconsumption of high-fat diet (HFD) and sugar-sweetened beverages are risk factors for developing obesity, insulin resistance, and fatty liver disease. Here…”
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Multivalent N‑Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing by Nair, Jayaprakash K., Willoughby, Jennifer L. S., Chan, Amy, Charisse, Klaus, Alam, Md. Rowshon, Wang, Qianfan, Hoekstra, Menno, Kandasamy, Pachamuthu, Kel’in, Alexander V., Milstein, Stuart, Taneja, Nate, O’Shea, Jonathan, Shaikh, Sarfraz, Zhang, Ligang, van der Sluis, Ronald J., Jung, Michael E., Akinc, Akin, Hutabarat, Renta, Kuchimanchi, Satya, Fitzgerald, Kevin, Zimmermann, Tracy, van Berkel, Theo J. C., Maier, Martin A., Rajeev, Kallanthottathil G., Manoharan, Muthiah

“…Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery…”
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins by Softic, Samir, Meyer, Jesse G, Wang, Guo-Xiao, Gupta, Manoj K, Batista, Thiago M, Lauritzen, Hans P M M, Fujisaka, Shiho, Serra, Dolors, Herrero, Laura, Willoughby, Jennifer, Fitzgerald, Kevin, Ilkayeva, Olga, Newgard, Christopher B, Gibson, Bradford W, Schilling, Birgit, Cohen, David E, Kahn, C Ronald

“…Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin…”
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Suburbanization, estrogen contamination, and sex ratio in wild amphibian populations by Lambert, Max R., Giller, Geoffrey S. J., Barber, Larry B., Fitzgerald, Kevin C., Skelly, David K.

“…Research on endocrine disruption in frog populations, such as shifts in sex ratios and feminization of males, has predominantly focused on agricultural…”
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Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria by Sardh, Eliane, Harper, Pauline, Balwani, Manisha, Stein, Penelope, Rees, David, Bissell, D. Montgomery, Desnick, Robert, Parker, Charles, Phillips, John, Bonkovsky, Herbert L, Vassiliou, Daphne, Penz, Craig, Chan-Daniels, Amy, He, Qiuling, Querbes, William, Fitzgerald, Kevin, Kim, Jae B, Garg, Pushkal, Vaishnaw, Akshay, Simon, Amy R, Anderson, Karl E

“…Acute intermittent porphyria results in excess activity of ALA synthase and overproduction of neurotoxic metabolites that cause attacks of severe abdominal…”
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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates by Nair, Jayaprakash K, Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R, Gupta, Swati, Willoughby, Jennifer L S, Boshar, Julie A, Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G, Akinc, Akin, Hutabarat, Renta, Maier, Martin A

“…Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein…”
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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial by Fitzgerald, Kevin, Dr, Frank-Kamenetsky, Maria, PhD, Shulga-Morskaya, Svetlana, MSc, Liebow, Abigail, BS, Bettencourt, Brian R, PhD, Sutherland, Jessica E, PhD, Hutabarat, Renta M, PhD, Clausen, Valerie A, PhD, Karsten, Verena, PhD, Cehelsky, Jeffrey, MBA, Nochur, Saraswathy V, PhD, Kotelianski, Victor, MD, Horton, Jay, MD, Mant, Timothy, MD, Chiesa, Joseph, MD, Ritter, James, MD, Munisamy, Malathy, MD, Vaishnaw, Akshay K, MD, Gollob, Jared A, MD, Simon, Amy, MD

“…Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that…”
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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates by Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.

“…siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as…”
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Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis by Coelho, Teresa, Adams, David, Silva, Ana, Lozeron, Pierre, Hawkins, Philip N, Mant, Timothy, Perez, Javier, Chiesa, Joseph, Warrington, Steve, Tranter, Elizabeth, Munisamy, Malathy, Falzone, Rick, Harrop, Jamie, Cehelsky, Jeffrey, Bettencourt, Brian R, Geissler, Mary, Butler, James S, Sehgal, Alfica, Meyers, Rachel E, Chen, Qingmin, Borland, Todd, Hutabarat, Renta M, Clausen, Valerie A, Alvarez, Rene, Fitzgerald, Kevin, Gamba-Vitalo, Christina, Nochur, Saraswathy V, Vaishnaw, Akshay K, Sah, Dinah W.Y, Gollob, Jared A, Suhr, Ole B

“…Transthyretin amyloidosis is largely caused by synthesis of mutant transthyretin in the liver and deposition of transthyretin in other organs. A therapeutic…”
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The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals by Moon, Young-Ah, Liang, Guosheng, Xie, Xuefen, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Brown, Michael S., Goldstein, Joseph L., Horton, Jay D.

“…Insulin resistance leads to hypertriglyceridemia and hepatic steatosis and is associated with increased SREBP-1c, a transcription factor that activates fatty…”
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Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice by Majmudar, Maulik D, Keliher, Edmund J, Heidt, Timo, Leuschner, Florian, Truelove, Jessica, Sena, Brena F, Gorbatov, Rostic, Iwamoto, Yoshiko, Dutta, Partha, Wojtkiewicz, Gregory, Courties, Gabriel, Sebas, Matt, Borodovsky, Anna, Fitzgerald, Kevin, Nolte, Marc W, Dickneite, Gerhard, Chen, John W, Anderson, Daniel G, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

“…BACKGROUND—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a…”
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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus by Kathiresan, Sekar, Rader, Daniel J, Musunuru, Kiran, Strong, Alanna, Frank-Kamenetsky, Maria, Lee, Noemi E, Ahfeldt, Tim, Sachs, Katherine V, Li, Xiaoyu, Li, Hui, Kuperwasser, Nicolas, Ruda, Vera M, Pirruccello, James P, Muchmore, Brian, Prokunina-Olsson, Ludmila, Hall, Jennifer L, Schadt, Eric E, Morales, Carlos R, Lund-Katz, Sissel, Phillips, Michael C, Wong, Jamie, Cantley, William, Racie, Timothy, Ejebe, Kenechi G, Orho-Melander, Marju, Melander, Olle, Koteliansky, Victor, Fitzgerald, Kevin, Krauss, Ronald M, Cowan, Chad A

“…Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein…”
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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1 by Guertin, David A., Stevens, Deanna M., Thoreen, Carson C., Burds, Aurora A., Kalaany, Nada Y., Moffat, Jason, Brown, Michael, Fitzgerald, Kevin J., Sabatini, David M.

“…The mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both…”
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