Search Results - "FITZGERALD, A. G"

Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus by Serrano, G E, Lelutiu, N, Rojas, A, Cochi, S, Shaw, R, Makinson, C D, Wang, D, FitzGerald, G A, Dingledine, R

“…Cyclooxygenase-2 (COX-2), a source of inflammatory mediators and a multifunctional neuronal modulator, is rapidly induced in select populations of cortical…”
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Systemic Biosynthesis of Prostacyclin by Cyclooxygenase (COX)-2: The Human Pharmacology of a Selective Inhibitor of COX-2 by McAdam, B. F., Catella-Lawson, F., Mardini, I. A., Kapoor, S., Lawson, J. A., Fitzgerald, G. A.

“…Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an…”
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Regulatory Science: What It Is and Why We Need It by FitzGerald, GA

“…“Regulatory science” could be interpreted as the “brand” of science pursued by regulatory agencies such as the US Food and Drug Administration (FDA). The…”
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Genetic and pharmacological analysis of prostanoid receptor function by Narumiya, S, FitzGerald, G A

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Effects of celecoxib on major prostaglandins in asthma by Daham, K., Song, W.- L., Lawson, J. A., Kupczyk, M., Gülich, A., Dahlén, S.-E., FitzGerald, G. A., Dahlén, B.

“…Summary Background Prostaglandin (PG) D2 is a pro‐inflammatory and bronchoconstrictive mediator released from mast cells, and is currently evaluated as a new…”
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Microsomal prostaglandin E synthase‐1 inhibition in cardiovascular inflammatory disease by Wang, M., Song, W.‐L., Cheng, Y., FitzGerald, G. A.

“… Prostaglandins (PGs), particularly PGE2 and prostacyclin (PGI2), are potent mediators of pain and inflammation. Both atherosclerosis and aortic aneurysm…”
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Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649 by Skarke, C, Alamuddin, N, Lawson, J A, Cen, L, Propert, K J, FitzGerald, G A

“…Nonsteroidal anti‐inflammatory drugs (NSAIDs) elevate cardiovascular risk by disrupting cyclooxygenase‐2 (COX‐2)‐dependent biosynthesis of prostacyclin (PGI2)…”
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Effect of assay specificity on the association of urine 11‐dehydro thromboxane B2 determination with cardiovascular risk by OLSON, M. T., KICKLER, T. S., LAWSON, J. A., MCLEAN, R. C., JANI, J., FITZGERALD, G. A., RADE, J. J.

“…Background: Elevated urine 11‐dehydro TXB2, an indicator of persistent thromboxane generation in aspirin‐treated patients, correlates with adverse…”
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Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles by Barry, O P, Pratico, D, Lawson, J A, FitzGerald, G A

“…Microparticles are released during platelet activation in vitro and have been detected in vivo in syndromes of platelet activation. They have been reported to…”
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Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease by Patrono, Carlo, FitzGerald, Garret A

“…Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human vascular disease. Their…”
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Modulation of monocyte-endothelial cell interactions by platelet microparticles by Barry, O P, Praticò, D, Savani, R C, FitzGerald, G A

“…Platelets, activated by various agonists, produce microparticles (MP) from the plasma membrane, which are released into the extracellular space. Although the…”
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Modulation of oxidant stress in vivo in chronic cigarette smokers by REILLY, M, DELANTY, N, LAWSON, J. A, FITZGERALD, G. A

“…Free radical-induced oxidative damage is thought to be involved in the pathogenesis of diseases associated with cigarette smoking. We examined the production…”
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Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation by McAdam, B F, Mardini, I A, Habib, A, Burke, A, Lawson, J A, Kapoor, S, FitzGerald, G A

“…To examine the role of cyclooxygenase (COX) isozymes in prostaglandin formation and oxidant stress in inflammation, we administered to volunteer subjects…”
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Anecdotes from ITMAT: Building Capacity for Translational Science by FitzGerald, G A

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Effect of oral prednisone on airway inflammatory mediators in atopic asthma by Dworski, R, Fitzgerald, G A, Oates, J A, Sheller, J R

“…The mechanism of steroid action in asthma is unknown. Because steroids have effects in vitro on eicosanoid synthesis, we determined the effect of oral…”
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The origin of electron beam patterning in silver/amorphous chalcogenide bilayers by Fitzgerald, A. G.

“…Previous studies of the effects of the interaction of electron beams with bilayers of amorphous chalcogenides and metals such as silver and copper have shown…”
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Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man by Wang, Z, Ciabattoni, G, Créminon, C, Lawson, J, Fitzgerald, G A, Patrono, C, Maclouf, J

“…F2-isoprostanes are prostaglandin (PG) F2-like compounds that are formed in vivo directly by free radical-catalyzed lipid peroxidation. One of the compounds…”
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COX-2 inhibitors and the cardiovascular system by FitzGerald, G A, Cheng, Y, Austin, S

“…Cyclooxygenase-2 selective inhibitors (coxibs) represent a new class of non steroidal anti-inflammatory drugs that exhibit preference for inhibition of…”
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Suppression of Thromboxane A2 but Not of Systemic Prostacyclin by Controlled-Release Aspirin by Clarke, Robert J, Mayo, Gail, Price, Patricia, FitzGerald, Garret A

“…ASPIRIN has been shown to reduce the incidence of death significantly in patients presenting with unstable coronary vascular disease. 1 2 3 The clinical…”
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A metabolomic study of adipose tissue in mice with a disruption of the circadian system by Castro, C, Briggs, W, Paschos, G K, FitzGerald, G A, Griffin, J L

“…Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In…”
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