Search Results - "FISK, Nicholas M"

Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process by Patel, Jatin, Seppanen, Elke J, Rodero, Mathieu P, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas M, Francois, Mathias, Khosrotehrani, Kiarash

“…BACKGROUND:During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate…”
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Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC by Guillot, Pascale V, Gotherstrom, Cecilia, Chan, Jerry, Kurata, Hiroshi, Fisk, Nicholas M

“…The biological properties of stem cells are key to the success of cell therapy, for which MSC are promising candidates. Although most therapeutic applications…”
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The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application by Zhang, Zhi-Yong, Teoh, Swee-Hin, Hui, James H.P, Fisk, Nicholas M, Choolani, Mahesh, Chan, Jerry K.Y

“…Abstract Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications. In this review, we…”
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Market failure and the poverty of new drugs in maternal health by Fisk, Nicholas M, Atun, Rifat

“…A new survey finds that only 17 drugs are under active development for maternal health indications, which is less than 3% of the pipeline in cardiovascular…”
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Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning by Gabbett, Michael T, Laporte, Johanna, Sekar, Renuka, Nandini, Adayapalam, McGrath, Pauline, Sapkota, Yadav, Jiang, Peiyong, Zhang, Haiqiang, Burgess, Trent, Montgomery, Grant W, Chiu, Rossa, Fisk, Nicholas M

“…Evaluation of monochorionic twins and their parents showed that each twin had inherited the same set of maternal alleles (i.e., both twins were derived from…”
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Small Molecule Mesengenic Induction of Human Induced Pluripotent Stem Cells to Generate Mesenchymal Stem/Stromal Cells by Chen, Yen Shun, Pelekanos, Rebecca A., Ellis, Rebecca L., Horne, Rachel, Wolvetang, Ernst J., Fisk, Nicholas M.

“…The translational potential of mesenchymal stem/stromal cells (MSCs) is limited by their rarity in somatic organs, heterogeneity, and need for harvest by…”
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Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model by Seppanen, Elke, Roy, Edwige, Ellis, Rebecca, Bou-Gharios, George, Fisk, Nicholas M, Khosrotehrani, Kiarash

“…The contribution of distant and/or bone marrow-derived endogenous mesenchymal stem cells (MSC) to skin wounds is controversial. Bone marrow transplantation…”
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Mesenchymal stem cells for systemic therapy: Shotgun approach or magic bullets? by Millard, Susan M., Fisk, Nicholas M.

“…Given their heterogeneity and lack of defining markers, it is surprising that multipotent mesenchymal stem/stromal cells (MSCs) have attracted so much…”
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Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity by Shafiee, Abbas, Patel, Jatin, Hutmacher, Dietmar W., Fisk, Nicholas M., Khosrotehrani, Kiarash

“…The existence of bipotential precursors for both mesenchymal and endothelial stem/progenitor cells in human postnatal life is debated. Here, we hypothesized…”
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Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow by Campagnoli, Cesare, Roberts, Irene A.G., Kumar, Sailesh, Bennett, Phillip R., Bellantuono, Ilaria, Fisk, Nicholas M.

“…Human mesenchymal stem/progenitor cells (MSCs) have been identified in adult bone marrow, but little is known about their presence during fetal life. MSCs were…”
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Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice by Guillot, Pascale V., Abass, Oyebode, Bassett, J.H. Duncan, Shefelbine, Sandra J., Bou-Gharios, George, Chan, Jerry, Kurata, Hitoshi, Williams, Graham R., Polak, Julia, Fisk, Nicholas M.

“…The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human…”
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Pre‐ and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two‐Center Experience by Götherström, Cecilia, Westgren, Magnus, Shaw, S.W. Steven, Åström, Eva, Biswas, Arijit, Byers, Peter H., Mattar, Citra N.Z., Graham, Gail E., Taslimi, Jahan, Ewald, Uwe, Fisk, Nicholas M., Yeoh, Allen E.J., Lin, Ju-Li, Cheng, Po-Jen, Choolani, Mahesh, Le Blanc, Katarina, Chan, Jerry K.Y.

“…This study reports the clinical course of two patients with osteogenesis imperfecta who received prenatal human fetal mesenchymal stem cell (MSC)…”
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Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations by Tunstall-Pedoe, Oliver, Roy, Anindita, Karadimitris, Anastasios, de la Fuente, Josu, Fisk, Nicholas M., Bennett, Phillip, Norton, Alice, Vyas, Paresh, Roberts, Irene

“…Down syndrome (DS) children have a high frequency of acute megakaryoblastic leukemia (AMKL) in early childhood. At least 2 in utero genetic events are…”
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Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects by Zhang, Zhi-Yong, Teoh, Swee-Hin, Chong, Mark S.K, Lee, Eddy S.M, Tan, Lay-Geok, Mattar, Citra N, Fisk, Nicholas M, Choolani, Mahesh, Chan, Jerry

“…Abstract Tissue-engineered bone grafts (TEBG) require highly osteogenic cell sources for use in fracture repair applications. Compared to other sources of…”
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Avoidance of Maternal Cell Contamination and Overgrowth in Isolating Fetal Chorionic Villi Mesenchymal Stem Cells from Human Term Placenta by Sardesai, Varda S., Shafiee, Abbas, Fisk, Nicholas M., Pelekanos, Rebecca A.

“…Human placenta is rich in mesenchymal stem/stromal cells (MSC), with their origin widely presumed fetal. Cultured placental MSCs are confounded by a high…”
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Ontological differences in first compared to third trimester human fetal placental chorionic stem cells by Jones, Gemma N, Moschidou, Dafni, Puga-Iglesias, Tamara-Isabel, Kuleszewicz, Katarzyna, Vanleene, Maximilien, Shefelbine, Sandra J, Bou-Gharios, George, Fisk, Nicholas M, David, Anna L, De Coppi, Paolo, Guillot, Pascale V

“…Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but…”
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Stem cell differentiation and expansion for clinical applications of tissue engineering by Guillot, Pascale V., Cui, Wei, Fisk, Nicholas M., Polak, Dame Julia

“…•  Introduction •  The essentials of tissue engineering ‐  Biomaterials ‐  Cell types for tissue engineering ‐  Stem cells ‐  Embryonic stem cells ‐  ‘Adult’…”
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Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties by Vanleene, Maximilien, Saldanha, Zahraa, Cloyd, Kristy L., Jell, Gavin, Bou-Gharios, George, Bassett, J. H. Duncan, Williams, Graham R., Fisk, Nicholas M., Oyen, Michelle L., Stevens, Molly M., Guillot, Pascale V., Shefelbine, Sandra J.

“…Osteogenesis imperfecta (OI or brittle bone disease) is a disorder of connective tissues caused by mutations in the collagen genes. We previously showed that…”
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Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources by Guillot, Pascale V., De Bari, Cosimo, Dell'Accio, Francesco, Kurata, Hitoshi, Polak, Julia, Fisk, Nicholas M.

“…Human mesenchymal stem cells (MSC) from adult and fetal tissues are promising candidates for cell therapy but there is a need to identify the optimal source…”
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Widespread Distribution and Muscle Differentiation of Human Fetal Mesenchymal Stem Cells After Intrauterine Transplantation in Dystrophic mdx Mouse by Chan, Jerry, Waddington, Simon N., O'Donoghue, Keelin, Kurata, Hitoshi, Guillot, Pascale V., Gotherstrom, Cecilia, Themis, Michael, Morgan, Jennifer E., Fisk, Nicholas M.

“…Duchenne muscular dystrophy (DMD) is a common X‐linked disease resulting from the absence of dystrophin in muscle. Affected boys suffer from incurable…”
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