Search Results - "FISCHKOFF, Steven"

Phase I/II Study of an Anti-CD30 Monoclonal Antibody (MDX-060) in Hodgkin's Lymphoma and Anaplastic Large-Cell Lymphoma by ANSELL, Stephen M, HORWITZ, Steven M, FISCHKOFF, Steven, ASSAD, Albert, BORCHMANN, Peter, ENGERT, Andreas, KHUDA DAD KHAN, LIN, Thomas, STRAIR, Roger, KELER, Tibor, GRAZIANO, Robert, BLANSET, Diann, YELLIN, Michael

“…MDX-060 is a human anti-CD30 immunoglobulin (Ig) G1kappa monoclonal antibody that inhibits growth of CD30-expressing tumor cells in preclinical models. To…”
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Safety and efficacy of intramuscular human placenta‐derived mesenchymal stromal‐like cells (cenplacel [PDA‐002]) in patients who have a diabetic foot ulcer with peripheral arterial disease by Wu, Stephanie C, Pollak, Richard, Frykberg, Robert G, Zhou, Wei, Karnoub, Maha, Jankovic, Vladimir, Fischkoff, Steven A, Chitkara, Denesh

“…The objective of this study was to examine the safety of cenplacel (PDA‐002) in patients with peripheral arterial disease (PAD) and a diabetic foot ulcer…”
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Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis) by FURST, Daniel E, SCHIFF, Michael H, FLEISCHMANN, Roy M, STRAND, Vibeke, BIRBARA, Charles A, COMPAGNONE, Daniele, FISCHKOFF, Steven A, CHARTASH, Elliot K

“…OBJECTIVE: This study, known as STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis), evaluated the safety and efficacy of adalimumab (Humira), a fully…”
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Safety and tolerability of human placenta-derived cells (PDA001) in treatment-resistant crohn's disease: a phase 1 study by Mayer, Lloyd, Pandak, William M, Melmed, Gil Y, Hanauer, Stephen B, Johnson, Kristine, Payne, Denise, Faleck, Herbert, Hariri, Robert J, Fischkoff, Steven A

“…The clinical utility of cellular therapies is being investigated in a broad range of therapeutic areas. This phase 1 study represents the first exploration of…”
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Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: A randomized, placebo-controlled, multiple-dose study by Lublin, Fred D, Bowen, James D, Huddlestone, John, Kremenchutzky, Marcelo, Carpenter, Adam, Corboy, John R, Freedman, Mark S, Krupp, Lauren, Paulo, Corri, Hariri, Robert J, Fischkoff, Steven A

“…Abstract Background Infusion of PDA-001, a preparation of mesenchymal-like cells derived from full-term human placenta, is a new approach in the treatment of…”
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Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: A pilot study by Weisman, Michael H., Moreland, Larry W., Furst, Daniel E., Weinblatt, Michael E., Keystone, Edward C., Paulus, Harold E., Teoh, Leah S., Velagapudi, Raja B., Noertersheuser, Peter A., Granneman, G.Richard, Fischkoff, Steven A., Chartash, Elliot K.

“…Background: Because traditional therapies for rheumatoid arthritis (RA) such as methotrexate (MTX) do not produce an adequate response in many patients, newer…”
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Phase IIa Study of the NPR-A Agonist, PL-3994, in Healthy Adult Volunteers with Controlled Hypertension by Sica, Domenic, Jordan, Robert, Fischkoff, Steven A

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Phase I Study of the Novel A-Type Natriuretic Receptor Agonist, PL-3994, in Healthy Volunteers by Jordan, Robert, Stark, Jill, Huskey, Su, Lata, Jennifer, Hallam, Trevor, Fischkoff, Steven A

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Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials by Spana, Carl, Jordan, Robert, Fischkoff, Steven

“…Aims The melanocortin 4 receptor (MC4R) plays a central role in appetite regulation, and agonistic activity at this receptor promotes satiety. Results from two…”
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Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial by Weinblatt, Michael E., Keystone, Edward C., Furst, Daniel E., Moreland, Larry W., Weisman, Michael H., Birbara, Charles A., Teoh, Leah A., Fischkoff, Steven A., Chartash, Elliot K.

“…Objective To evaluate the efficacy and safety of adalimumab (D2E7), a fully human monoclonal tumor necrosis factor α antibody, in combination with methotrexate…”
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Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial by Keystone, Edward C., Kavanaugh, Arthur F., Sharp, John T., Tannenbaum, Hyman, Hua, Ye, Teoh, Leah S., Fischkoff, Steven A., Chartash, Elliot K.

“…Objective Tumor necrosis factor (TNF) is an important proinflammatory cytokine that mediates inflammatory synovitis and articular matrix degradation in…”
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Stem Cells as an Emerging Paradigm in Stroke 3: Enhancing the Development of Clinical Trials by SAVITZ, Sean I, CRAMER, Steven C, WECHSLER, Lawrence

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Phase 1 study of ADG126, a novel masked anti-CTLA-4 SAFEbody, that combines tumor-localized activation with strong T reg depletion and soft ligand blocking in patients with advanced solid tumors by Richardson, Gary Edward, Tolcher, Anthony W., Morris, Michelle Frances, de Souza, Paul L., Hamid, Anis, She, Xiaohong, Zhu, Lvyu, Wang, Hongyan, Zheng, Songmao, Liu, Guizhong, Li, Yan, Du, Fangyong Felix, Fischkoff, Steven, Gong, Hua, Zha, Jiping, Luo, Peter

“…e17601 Background: SAFEbody ADG126, a masked version of NEObody ADG116 (ESMO IO Conference Abstract #394, NCT04501276), targets a unique species-conserved…”
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Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II by SAVITZ, Sean I, CHOPP, Michael, DEANS, Robert, CARMICHAEL, S. T, PHINNEY, Donald, WECHSLER, Larry

“…Cell-based therapies represent a new therapeutic approach for stroke. In 2007, investigators from academia, industry leaders, and members of the National…”
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Human Placenta-derived Cells (PDA-001) for the Treatment of Moderate-to-severe Crohn's Disease: A Phase 1b/2a Study by Melmed, Gil Y, Pandak, William M, Casey, Kevin, Abraham, Bincy, Valentine, John, Schwartz, David, Awais, Dahlia, Bassan, Issac, Lichtiger, Simon, Sands, Bruce, Hanauer, Stephen, Richards, Robert, Oikonomou, Ioannis, Parekh, Nimisha, Targan, Stephen, Johnson, Kristine, Hariri, Robert, Fischkoff, Steven

“…PDA-001 (cenplacel-L), a preparation of placenta-derived mesenchymal-like adherent cells with immunomodulatory effects, previously demonstrated safety and…”
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Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels by Panacek, Edward A, Marshall, John C, Albertson, Timothy E, Johnson, David H, Johnson, Steven, MacArthur, Rodger D, Miller, Mark, Barchuk, William T, Fischkoff, Steven, Kaul, Martin, Teoh, Leah, Van Meter, Lori, Daum, Lothar, Lemeshow, Stanley, Hicklin, Gregory, Doig, Christopher

“…OBJECTIVE:To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F(ab′)2 monoclonal antibody fragment, would reduce 28-day all-cause…”
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Efficacy of single administration of tumor-infiltrating lymphocytes (TIL) in heavily pretreated patients with metastatic melanoma following checkpoint therapy by Sarnaik, Amod, Kluger, Harriet M., Chesney, Jason Alan, Sethuraman, Jyothi, Veerapathran, Anandharamen, Simpson-Abelson, Michelle, Lotze, Michael T., Larsen, Bente, Fischkoff, Steven A., Suzuki, Sam, Wang, Lei, Mirgoli, Mariam, Fardis, Maria, Curti, Brendan D.

“…Abstract only 3045 Background: Adoptive cell therapy with TIL involves collection of autologous lymphocytes from the tumor via surgical resection, ex vivo…”
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Placenta-derived mesenchymal-like cells (PDA-001) as therapy for chronic pulmonary sarcoidosis: a phase 1 study by Baughman, Robert P, Culver, Daniel A, Jankovi, Vladimir, Fischkoff, Steven, Brockway, Giorgia, Lower, Elyse E

“…Placental derived mesenchymal-like cells have been found to have immunosuppressive effects on T cell function. We studied mesenchymal-like cells as…”
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Human Placenta-Derived Cells (PDA001) for the Treatment of Moderate-to-Severe Crohnʼs Disease: Results of a Phase 1b/2a Study: 1576 by Melmed, Gil, Pandak, William, Casey, Kevin, Abraham, Bincy, Valentine, John, Schwartz, David, Awais, Dahllia, Lichtiger, Simon, Bassan, Isaac, Hanauer, Stephen, Richards, Robert, Oilonomou, Ioannis, Parekh, Nimisha, Targan, Stephan, Johnson, Kristine, Hariri, Robert, Fischkoff, Steven

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Switch in differentiative response to maturation inducers of human promyelocytic leukemia cells by prior exposure to alkaline conditions by FISCHKOFF, S. A, CONDON, M. E

“…The myeloid lineage to which HL-60 promyelocytic leukemia cells will differentiate in response to a chemical differentiation inducer can be switched by…”
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