Search Results - "FISCHER, Will"

T cell-based strategies for HIV-1 vaccines by Korber, Bette, Fischer, Will

“…Despite 30 years of effort, we do not have an effective HIV-1 vaccine. Over the past decade, the HIV-1 vaccine field has shifted emphasis toward antibody-based…”
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus by Korber, Bette, Fischer, Will M., Gnanakaran, Sandrasegaram, Yoon, Hyejin, Theiler, James, Abfalterer, Werner, Hengartner, Nick, Giorgi, Elena E., Bhattacharya, Tanmoy, Foley, Brian, Hastie, Kathryn M., Parker, Matthew D., Partridge, David G., Evans, Cariad M., Freeman, Timothy M., de Silva, Thushan I., Angyal, Adrienne, Brown, Rebecca L., Carrilero, Laura, Green, Luke R., Groves, Danielle C., Johnson, Katie J., Keeley, Alexander J., Lindsey, Benjamin B., Parsons, Paul J., Raza, Mohammad, Rowland-Jones, Sarah, Smith, Nikki, Tucker, Rachel M., Wang, Dennis, Wyles, Matthew D., McDanal, Charlene, Perez, Lautaro G., Tang, Haili, Moon-Walker, Alex, Whelan, Sean P., LaBranche, Celia C., Saphire, Erica O., Montefiori, David C.

“…A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant…”
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Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates by Uraki, Ryuta, Iida, Shun, Halfmann, Peter J., Yamayoshi, Seiya, Hirata, Yuichiro, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Ito, Mutsumi, Furusawa, Yuri, Ueki, Hiroshi, Sakai-Tagawa, Yuko, Kuroda, Makoto, Maemura, Tadashi, Kim, Taksoo, Mine, Sohtaro, Iwamoto, Noriko, Li, Rong, Liu, Yanan, Larson, Deanna, Fukushi, Shuetsu, Watanabe, Shinji, Maeda, Ken, Wang, Zhongde, Ohmagari, Norio, Theiler, James, Fischer, Will, Korber, Bette, Imai, Masaki, Suzuki, Tadaki, Kawaoka, Yoshihiro

“…The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological…”
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HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens by Fischer, Will, Giorgi, Elena E., Chakraborty, Srirupa, Nguyen, Kien, Bhattacharya, Tanmoy, Theiler, James, Goloboff, Pablo A., Yoon, Hyejin, Abfalterer, Werner, Foley, Brian T., Tegally, Houriiyah, San, James Emmanuel, de Oliveira, Tulio, Wilkinson, Eduan, Msomi, Nokukhanya, Iranzadeh, Arash, Fonseca, Vagner, Doolabh, Deelan, Mlisana, Koleka, von Gottberg, Anne, Walaza, Sibongile, Allam, Mushal, Ismail, Arshad, Mohale, Thabo, Glass, Allison J., Engelbrecht, Susan, Van Zyl, Gert, Preiser, Wolfgang, Petruccione, Francesco, Sigal, Alex, Hardie, Diana, Marais, Gert, Hsiao, Marvin, Korsman, Stephen, Davies, Mary-Ann, Tyers, Lynn, Mudau, Innocent, York, Denis, Maslo, Caroline, Goedhals, Dominique, Abrahams, Shareef, Laguda-Akingba, Oluwakemi, Alisoltani-Dehkordi, Arghavan, Godzik, Adam, Wibmer, Constantinos Kurt, Sewell, Bryan Trevor, Lourenço, José, Pond, Sergei L. Kosakovsky, Weaver, Steven, Giovanetti, Marta, Alcantara, Luiz Carlos Junior, Martin, Darren, Bhiman, Jinal N., Williamson, Carolyn, Gnanakaran, Sandrasegaram, Korber, Bette

“…Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades,…”
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US National Institutes of Health Prioritization of SARS-CoV-2 Variants by Turner, Sam, Alisoltani, Arghavan, Bratt, Debbie, Cohen-Lavi, Liel, Dearlove, Bethany L, Drosten, Christian, Fischer, Will M, Fouchier, Ron A M, Gonzalez-Reiche, Ana Silvia, Jaroszewski, Lukasz, Khalil, Zain, LeGresley, Eric, Johnson, Marc, Jones, Terry C, Mühlemann, Barbara, O'Connor, David, Sedova, Mayya, Shukla, Maulik, Theiler, James, Wallace, Zachary S, Yoon, Hyejin, Zhang, Yun, van Bakel, Harm, Degrace, Marciela M, Ghedin, Elodie, Godzik, Adam, Hertz, Tomer, Korber, Bette, Lemieux, Jacob, Niewiadomska, Anna M, Post, Diane J, Rolland, Morgane, Scheuermann, Richard, Smith, Derek J

“…Since late 2020, SARS-CoV-2 variants have regularly emerged with competitive and phenotypic differences from previously circulating strains, sometimes with the…”
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Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys by Barouch, Dan H, O'Brien, Kara L, Simmons, Nathaniel L, King, Sharon L, Abbink, Peter, Maxfield, Lori F, Sun, Ying-Hua, La Porte, Annalena, Riggs, Ambryice M, Lynch, Diana M, Clark, Sarah L, Backus, Katherine, Perry, James R, Seaman, Michael S, Carville, Angela, Mansfield, Keith G, Szinger, James J, Fischer, Will, Muldoon, Mark, Korber, Bette

“…The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development. Antigens derived from natural HIV-1 sequences have elicited only…”
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Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial by Campion, Suzanne L, Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin, McLaren, James E, Price, David A, Frahm, Nicole, McElrath, Juliana M, Cohen, Kristen W, Maenza, Janine R, Walsh, Stephen R, Baden, Lindsey R, Haynes, Barton F, Korber, Bette, Borrow, Persephone, McMichael, Andrew J

“…Naive and memory CD4+ T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution…”
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Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing by Fischer, Will, Ganusov, Vitaly V, Giorgi, Elena E, Hraber, Peter T, Keele, Brandon F, Leitner, Thomas, Han, Cliff S, Gleasner, Cheryl D, Green, Lance, Lo, Chien-Chi, Nag, Ambarish, Wallstrom, Timothy C, Wang, Shuyi, McMichael, Andrew J, Haynes, Barton F, Hahn, Beatrice H, Perelson, Alan S, Borrow, Persephone, Shaw, George M, Bhattacharya, Tanmoy, Korber, Bette T

“…We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three…”
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Sparse coding of pathology slides compared to transfer learning with deep neural networks by Fischer, Will, Moudgalya, Sanketh S, Cohn, Judith D, Nguyen, Nga T T, Kenyon, Garrett T

“…Histopathology images of tumor biopsies present unique challenges for applying machine learning to the diagnosis and treatment of cancer. The pathology slides…”
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Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection by Kim, Eun-Young, Lorenzo-Redondo, Ramon, Little, Susan J, Chung, Yoon-Seok, Phalora, Prabhjeet K, Maljkovic Berry, Irina, Archer, John, Penugonda, Sudhir, Fischer, Will, Richman, Douglas D, Bhattacharya, Tanmoy, Malim, Michael H, Wolinsky, Steven M

“…Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and…”
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Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection by Kijak, Gustavo H, Sanders-Buell, Eric, Chenine, Agnes-Laurence, Eller, Michael A, Goonetilleke, Nilu, Thomas, Rasmi, Leviyang, Sivan, Harbolick, Elizabeth A, Bose, Meera, Pham, Phuc, Oropeza, Celina, Poltavee, Kultida, O'Sullivan, Anne Marie, Billings, Erik, Merbah, Melanie, Costanzo, Margaret C, Warren, Joanna A, Slike, Bonnie, Li, Hui, Peachman, Kristina K, Fischer, Will, Gao, Feng, Cicala, Claudia, Arthos, James, Eller, Leigh A, O'Connell, Robert J, Sinei, Samuel, Maganga, Lucas, Kibuuka, Hannah, Nitayaphan, Sorachai, Rao, Mangala, Marovich, Mary A, Krebs, Shelly J, Rolland, Morgane, Korber, Bette T, Shaw, George M, Michael, Nelson L, Robb, Merlin L, Tovanabutra, Sodsai, Kim, Jerome H

“…In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events occurring during acute HIV-1…”
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Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses by Stromberg, Zachary R., Fischer, Will, Bradfute, Steven B., Kubicek-Sutherland, Jessica Z., Hraber, Peter

“…Vaccinations are a crucial intervention in combating infectious diseases. The three neurotropic Alphaviruses, Eastern (EEEV), Venezuelan (VEEV), and Western…”
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A multiple-alignment based primer design algorithm for genetically highly variable DNA targets by Brodin, Johanna, Krishnamoorthy, Mohan, Athreya, Gayathri, Fischer, Will, Hraber, Peter, Gleasner, Cheryl, Green, Lance, Korber, Bette, Leitner, Thomas

“…Primer design for highly variable DNA sequences is difficult, and experimental success requires attention to many interacting constraints. The advent of…”
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Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus Lineages by FISCHER, Will, APETREI, Cristian, KORBER, Bette T, SANTIAGO, Mario L, YINGYING LI, GAUTAM, Rajeev, PANDREA, Ivona, SHAW, George M, HAHN, Beatrice H, LETVIN, Norman L, NABEL, Gary J

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells by Smith, Kellie N, Mailliard, Robbie B, Piazza, Paolo A, Fischer, Will, Korber, Bette T, Fecek, Ronald J, Ratner, Deena, Gupta, Phalguni, Mullins, James I, Rinaldo, Charles R

“…Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy…”
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Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination by KONG, Wing-Pui, LAN WU, NABEL, Gary J, WALLSTROM, Timothy C, FISCHER, Will, YANG, Zhi-Yong, KO, Sung-Youl, LETVIN, Norman L, HAYNES, Barton F, HAHN, Beatrice H, KORBER, Bette

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection by Kijak, Gustavo H, Sanders-Buell, Eric, Chenine, Agnes-Laurence, Eller, Michael A, Goonetilleke, Nilu, Thomas, Rasmi, Leviyang, Sivan, Harbolick, Elizabeth A, Bose, Meera, Pham, Phuc, Oropeza, Celina, Poltavee, Kultida, O'Sullivan, Anne Marie, Billings, Erik, Merbah, Melanie, Costanzo, Margaret C, Warren, Joanna A, Slike, Bonnie, Li, Hui, Peachman, Kristina K, Fischer, Will, Gao, Feng, Cicala, Claudia, Arthos, James, Eller, Leigh A, O'Connell, Robert J, Sinei, Samuel, Maganga, Lucas, Kibuuka, Hannah, Nitayaphan, Sorachai, Rao, Mangala, Marovich, Mary A, Krebs, Shelly J, Rolland, Morgane, Korber, Bette T, Shaw, George M, Michael, Nelson L, Robb, Merlin L, Tovanabutra, Sodsai, Kim, Jerome H

“…[This corrects the article DOI: 10.1371/journal.ppat.1006510.]…”
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Epitope-Specific CD8+ T Lymphocytes Cross-Recognize Mutant Simian Immunodeficiency Virus (SIV) Sequences but Fail To Contain Very Early Evolution and Eventual Fixation of Epitope Escape Mutations during SIV Infection by CALE, Evan M, HRABER, Peter, KORBER, Bette, LETVIN, Norman L, GIORGI, Elena E, FISCHER, Will, BHATTACHARYA, Tanmoy, LEITNER, Thomas, YEH, Wendy W, GLEASNER, Cheryl, GREEN, Lance D, HAN, Cliff S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State by Lappala, Anna, Nishima, Wataru, Miner, Jacob, Fenimore, Paul, Fischer, Will, Hraber, Peter, Zhang, Ming, McMahon, Benjamin, Tung, Chang-Shung

“…Membrane fusion proteins are responsible for viral entry into host cells-a crucial first step in viral infection. These proteins undergo large conformational…”
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Erratum for Smith et al., Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells by Smith, Kellie N, Mailliard, Robbie B, Piazza, Paolo A, Fischer, Will, Korber, Bette T, Fecek, Ronald J, Ratner, Deena, Gupta, Phalguni, Mullins, James I, Rinaldo, Charles R

“…Volume 7, no. 3, doi:10.1128/mBio.00473-16, 2016. For transparency, the legend to Fig. 7 has been revised to include additional information that was…”
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