Search Results - "FISCHER, M. J. E"

Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects by Fischer, M J, Paulussen, J J, Horbach, D A, Roelofsen, E P, van Miltenburg, J C, de Mol, N J, Janssen, L H

“…In a model for mucosal mast cells (RBL-2H3 cells) a set H1-antagonist derived anti-allergic drugs containing a diphenylmethyl piperazinyl moiety was examined…”
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The Molecular Mechanism of the Neutral-to-Base Transition of Human Serum Albumin by Bos, O J M, Labro, J F A, Fischer, M J E, Wilting, J, Janssen, L H M

“…In order to obtain a better understanding of the neutral-to-base (N-B) transition of human serum albumin, we performed acid/base titration experiments and…”
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The vestibular functions of the manganese-deficient rat by Huygen, P L, Fischer, A J, Kuijpers, W

“…Vestibular functions were examined in 25 animals of the second generation of rats raised on a manganese-deficient diet; 9 animals appeared to be normal and 16…”
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Dual effect of the anti-allergic astemizole on Ca2+ fluxes in rat basophilic leukemia (RBL-2H3) cells : Release of Ca2+ from intracellular stores and inhibition of Ca2+ release-activated Ca2+ influx by FISCHER, M. J. E, PAULUSSEN, J. J. C, DE MOL, N. J, JANSSEN, L. H. M

“…The antiallergic drugs astemizole and norastemizole inhibit exocytosis in mast cells, which might be relevant for their therapeutic action. From previous…”
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The molecular mechanism of the neutral-to-base transition of human serum albumin. Acid/base titration and proton nuclear magnetic resonance studies on a large peptic and a large tryptic fragment of albumin by BOS, O. J. M, LABRO, J. F. A, FISCHER, M. J. E, WILTING, J, JANSSEN, L. H. M

“…In order to obtain a better understanding of the neutral-to-base (N-B) transition of human serum albumin, we performed acid/base titration experiments and…”
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The role of protein charge in protein-lipid interactions. pH-Dependent changes of the electrophoretic mobility of liposomes through adsorption of water-soluble, globular proteins by Bergers, Joep J, Vingerhoeds, Monique H, van Bloois, Louis, Herron, James N, Janssen, Lambert H. M, Fischer, Marcel J. E, Crommelin, Daan J. A

“…The role of electrostatics in the adsorption process of proteins to preformed negatively-charged (phosphatidylcholine/phosphatidylglycerol) and neutral…”
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Mechanism of action of the nonlipophilic antiallergic drug eclazolast (REV 2871) in the inhibition of mediator release in a mast cell model by Fischer, M J, de Mol, N J

“…In this study, we compared eclazolast with other lipophilic antiallergic drugs, relating to effects on signal transduction pathways, leading to inhibition of…”
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The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action by Vansterkenburg, E L, Coppens, I, Wilting, J, Bos, O J, Fischer, M J, Janssen, L H, Opperdoes, F R

“…In plasma, a significant part of suramin circulates in tight association with low-density lipoproteins (LDL). At therapeutically obtainable concentrations (100…”
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Structure-activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis by FISCHER, M. J. E, PAULUSSEN, J. J. C, TOLLENAERE, J. P, DE MOL, N. J, JANSSEN, L. H. M

“…The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme beta-hexosaminidase were studied in a mast cell model,…”
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Influence of the antiallergic drug oxatomide and derivatives on membrane structures: relation with inhibition of calcium influx in rat basophilic leukemia cells by Paulussen, Jeannette J.C., Fischer, Marcel J.E., Zuidam, Nicolaas J., v. Miltenburg, J.Cees, de Mol, Nico J., Janssen, Lambert H.M.

“…Oxatomide is an H 1 antihistaminic drug that also inhibits mediator release from mast cells. From previous studies, it appeared that inhibition of the influx…”
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Effects of oxatomide and derivatives on high affinity IgE receptor-activated signal transduction pathways in rat basophilic leukemia cells: role of protein tyrosine hyperphosphorylation and inhibition of extracellular calcium influx by Paulussen, Jeannette J.C, Fischer, Marcel J.E, Roozendaal, Ramon L, van der Heijden, Vincent C, van Dijken, Peter, de Mol, Nico J, Janssen, Lambert H.M

“…The antiallergic drug oxatomide and analogs inhibit mediator release from a rat basophilic leukemia (RBL-2H3) cell line, which is frequently used as a mast…”
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Location and characterization of the warfarin binding site of human serum albumin. A comparative study of two large fragments by Bos, O J, Remijn, J P, Fischer, M J, Wilting, J, Janssen, L H

“…The warfarin binding behaviour of a large tryptic fragment (residues 198-585 which comprise domains two and three) and of a large peptic fragment (residues…”
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Influence of the anti-allergic drug oxatomide on the signal transduction mechanism in a mast cell model by Paulussen, Jeannette J.C., Fischer, Marcel J.E., Kok-Van Esterik, Jolien A.E., Tiemessen, Radboud C., De Mol, Nico J., Janssen, Lambert H.M.

“…In a mast cell model, oxatomide displays inhibition of mediator release which is not related to its histamine H 1 receptor antagonistic activity. From a…”
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Oxidation of chlorpromazine by methemoglobin in the presence of hydrogen peroxide. Formation of chlorpromazine radical cation and its covalent binding to methemoglobin by Kelder, P P, Fischer, M J, de Mol, N J, Janssen, L H

“…The oxidation of chlorpromazine by methemoglobin plus H2O2 has been studied. The transient formation of the chlorpromazine radical cation in this reaction has…”
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Steroid binding to human serum albumin and fragments thereof. Role of protein conformation and fatty acid content by Fischer, M J, Bos, O J, van der Linden, R F, Wilting, J, Janssen, L H

“…The binding properties of the steroids testosterone and pregnenolone to human serum albumin (HSA) and derived fragments of albumin have been investigated by…”
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Relation between effects of a set of anti-allergic drugs on calcium pathways and membrane structure in Fc∈RI activated signal transduction by Fischer, M. J. E., Paulussen, J. J. C., Roozendaal, R., Tiemessen, R. C., de Mol, N. J., Janssen, L. H. M.

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Mechanism by which warfarin binds to human serum albumin. Stopped-flow kinetic experiments with two large fragments of albumin by Bos, O J, Fischer, M J, Wilting, J, Janssen, L H

“…In order to obtain information about the kinetics of the process by which warfarin binds to human serum albumin at a molecular level, we performed stopped-flow…”
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Effects of the anti-allergics astemizole and norastemizole on FcεRI receptor-mediated signal transduction processes by Fischer, Marcel J.E, Paulussen, Jeannette J.C, Kok-Van Esterik, Jolien A.E, Van der Heijden, Vincent S, De Mol, Nico J, Janssen, Lambert H.M

“…The non-sedating anti-allergic drug astemizole, apart from its potential to antagonise H 1 receptors, inhibits the release of inflammation mediators from mast…”
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Kinetic evaluation of the oxidation of phenothiazine derivatives by methemoglobin and horseradish peroxidase in the presence of hydrogen peroxide. Implications for the reaction mechanisms by Kelder, P P, de Mol, N J, Fischer, M J, Janssen, L H

“…The oxidation of ten 2-substituted 10-(3-(dimethylamino)propyl) phenothiazines (PHs) by methemoglobin (metHb) and horseradish peroxidase (HRP) in the presence…”
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Location and characterization of the suramin binding sites of human serum albumin by Bos, O J, Vansterkenburg, E L, Boon, J P, Fischer, M J, Wilting, J, Janssen, L H

“…The objective of the present study was to investigate the location of the high-affinity suramin binding sites on the human serum albumin molecule. For this…”
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