Search Results - "FIRESTEIN, B. L"

Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles by Ko, J, Hemphill, M, Yang, Z, Sewell, E, Na, Y J, Sandsmark, D K, Haber, M, Fisher, S A, Torre, E A, Svane, K C, Omelchenko, A, Firestein, B L, Diaz-Arrastia, R, Kim, J, Meaney, D F, Issadore, D

“…The accurate diagnosis and clinical management of traumatic brain injury (TBI) is currently limited by the lack of accessible molecular biomarkers that reflect…”
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DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation by Firestein, B L, Rongo, C

“…Cellular junctions are critical for intercellular communication and for the assembly of cells into tissues. Cell junctions often consist of tight junctions,…”
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Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2 by BALBOA, M. A, FIRESTEIN, B. L, GODSON, C, BELL, K. S, INSEL, P. A

“…Protein kinase C (PKC) has been implicated in the activation of phospholipase D (PLD) in a number of systems. By antisense technology, we have "knocked out"…”
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Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells by Firestein, B L, Xing, M, Hughes, R J, Corvera, C U, Insel, P A

“…We have characterized the signaling pathways of purinergic receptors present on the renal epithelial cell line, Madin-Darby canine kidney (MDCK, D1 subclone)…”
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Regulation of Sensory Neuron Precursor Proliferation by Cyclic GMP‐Dependent Protein Kinase by Firestein, Bonnie L., Bredt, David S.

“…: Cyclic GMP (cGMP) is a molecular messenger involved in diverse cellular processes. Recently, cGMP‐dependent protein kinase (cGK) type II was determined to be…”
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Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia by Hardin, Jeffrey D, Köppen, Mathias, Simske, Jeffrey S, Sims, Paul A, Firestein, Bonnie L, Hall, David H, Radice, Anthony D, Rongo, Christopher

“…The function of epithelial cell sheets depends on the integrity of specialized cell-cell junctions that connect neighbouring cells. We have characterized the…”
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Nitric oxide mediated induction of cytochrome c oxidase mRNA and protein in a mouse macrophage cell line by Lehrer-Graiwer, Joshua E, Firestein, Bonnie L, Bredt, David S

“…Neurons that express neuronal nitric oxide synthase (nNOS) are selectively spared from nitric oxide (NO)-induced cytotoxicity in acute cerebral ischemia and…”
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PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands by Torres, Richard, Firestein, Bonnie L, Dong, Hualing, Staudinger, Jeff, Olson, Eric N, Huganir, Richard L, Bredt, David S, Gale, Nicholas W, Yancopoulos, George D

“…Localizing cell surface receptors to specific subcellular positions can be critical for their proper functioning, as most notably demonstrated at neuronal…”
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Dual Palmitoylation of PSD-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering by El-Husseini, Alaa E., Craven, Sarah E., Chetkovich, Dane M., Firestein, Bonnie L., Schnell, Eric, Aoki, Chiye, Bredt, David S.

“…Postsynaptic density-95 (PSD-95/SAP-90) is a palmitoylated peripheral membrane protein that scaffolds ion channels at excitatory synapses. To elucidate…”
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Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS by Riefler, G M, Firestein, B L

“…Recent work suggests a role for PDZ domains in the targeting of binding partners to specific sites in the cell. To identify whether the PDZ domain of neuronal…”
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Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs by El-Husseini, A E, Topinka, J R, Lehrer-Graiwer, J E, Firestein, B L, Craven, S E, Aoki, C, Bredt, D S

“…The postsynaptic density protein PSD-95 and related membrane-associated guanylate kinase (MAGUK) proteins assemble signal transduction complexes at sites of…”
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Interaction of Neuronal Nitric-oxide Synthase and Phosphofructokinase-M by Firestein, B L, Bredt, D S

“…Neurons that express neuronal nitric-oxide synthase (nNOS) are resistant to NO-induced neurotoxicity; however, the mechanism by which these neurons are…”
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Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: an assessment of graft size and ultrastructure by Kawaja, M D, Fagan, A M, Firestein, B L, Gage, F H

“…To identify a suitable donor cell population for gene therapy applications to the central nervous system, primary fibroblasts isolated from skin biopsies and…”
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Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly by Firestein, Bonnie L, Akum, Barbara F, Chen, Maxine, Gunderson, Samuel I, Riefler, Gary M, Scerri-Hansen, Monica M

“…Dendrite branching has an important role in normal brain function. Here we report that overexpression of cypin, a protein that has guanine deaminase activity…”
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Cypin: A Cytosolic Regulator of PSD-95 Postsynaptic Targeting by Firestein, Bonnie L, Brenman, Jay E, Aoki, Chiye, Sanchez-Perez, Ana M, El-Husseini, Alaa El-Din, Bredt, David S

“…Postsynaptic density 95 (PSD-95/SAP-90) is a membrane associated guanylate kinase (GK) PDZ protein that scaffolds glutamate receptors and associated signaling…”
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P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides by Insel, P A, Ostrom, R S, Zambon, A C, Hughes, R J, Balboa, M A, Shehnaz, D, Gregorian, C, Torres, B, Firestein, B L, Xing, M, Post, S R

“…1. Madin-Darby canine kidney (MDCK) cells, a well- differentiated renal epithelial cell line derived from distal tubule/collecting duct, respond to…”
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Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains by Firestein, Bonnie L, Craven, Sarah E, Bredt, David S

“…Postsynaptic targeting of PSD-95 has been extensively studied; however, little is known about how other MAGUKs are localized. Proper targeting of PSD-95…”
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BDNF-promoted increases in proximal dendrites occur via CREB-dependent transcriptional regulation of cypin by Kwon, Munjin, Fernández, José R, Zegarek, Gregory F, Lo, Sean B, Firestein, Bonnie L

“…Alterations in dendrite branching and morphology are present in many neurodegenerative diseases. These variations disrupt postsynaptic transmission and affect…”
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Effect of dynamic stiffness of the substrates on neurite outgrowth by using a DNA-crosslinked hydrogel by Jiang, Frank Xue, Yurke, Bernard, Schloss, Rene S, Firestein, Bonnie L, Langrana, Noshir A

“…Central nervous system tissues, like other tissue types, undergo constant remodeling, which potentially leads to changes in their mechanical stiffness…”
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NOS1AP Regulates Dendrite Patterning of Hippocampal Neurons through a Carboxypeptidase E-Mediated Pathway by Carrel, Damien, Du, Yangzhou, Komlos, Daniel, Hadzimichalis, Norell M, Kwon, Munjin, Wang, Bo, Brzustowicz, Linda M, Firestein, Bonnie L

“…During neuronal development, neurons form elaborate dendritic arbors that receive signals from axons. Additional studies are needed to elucidate the factors…”
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