Search Results - "FIORENTINI, Carla"

Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction by Fossatelli, Laura, Maroccia, Zaira, Fiorentini, Carla, Bonucci, Massimo

“…Apigenin is one of the most widespread flavonoids in the plant kingdom. For centuries, apigenin-containing plant preparations have been used in traditional…”
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Effects of the Escherichia coli Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review by Carlini, Francesca, Maroccia, Zaira, Fiorentini, Carla, Travaglione, Sara, Fabbri, Alessia

“…Cytotoxic necrotizing factor 1 (CNF1) is a bacterial virulence factor, the target of which is represented by Rho GTPases, small proteins involved in a huge…”
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Inflammation and colorectal cancer, when microbiota-host mutualism breaks by Candela, Marco, Turroni, Silvia, Biagi, Elena, Carbonero, Franck, Rampelli, Simone, Fiorentini, Carla, Brigidi, Patrizia

“…Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss…”
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Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins? by Fiorentini, Carla, Carlini, Francesca, Germinario, Elena Angela Pia, Maroccia, Zaira, Travaglione, Sara, Fabbri, Alessia

“…Accumulating evidence indicates that the human intestinal microbiota can contribute to the etiology of colorectal cancer. Triggering factors, including…”
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Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment by Pizzo, Federica, Maroccia, Zaira, Hammarberg Ferri, Ivano, Fiorentini, Carla

“…The microbiota is increasingly recognized as a critical player in cancer onset and progression and response to cancer chemotherapy treatment. In recent years,…”
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Modulation of RhoGTPases Improves the Behavioral Phenotype and Reverses Astrocytic Deficits in a Mouse Model of Rett Syndrome by DE FILIPPIS, Bianca, FABBRI, Alessia, SIMONE, Daiana, CANESE, Rossella, RICCERI, Laura, MALCHIODI-ALBEDI, Fiorella, LAVIOLA, Giovanni, FIORENTINI, Carla

“…RhoGTPases are crucial molecules in neuronal plasticity and cognition, as confirmed by their role in non-syndromic mental retardation. Activation of brain…”
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Protective Effect of Limosilactobacillus fermentum ME-3 against the Increase in Paracellular Permeability Induced by Chemotherapy or Inflammatory Conditions in Caco-2 Cell Models by De Gregorio, Alex, Serafino, Annalucia, Krasnowska, Ewa Krystyna, Superti, Fabiana, Di Fazio, Maria Rosa, Fuggetta, Maria Pia, Hammarberg Ferri, Ivano, Fiorentini, Carla

“…Chemotherapy- or inflammation-induced increase in intestinal permeability represents a severe element in disease evolution in patients suffering from…”
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The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence by Messina, Valeria, Loizzo, Stefano, Travaglione, Sara, Bertuccini, Lucia, Condello, Maria, Superti, Fabiana, Guidotti, Marco, Alano, Pietro, Silvestrini, Francesco, Fiorentini, Carla

“…Plasmodium falciparum severe malaria causes more than 400,000 deaths every year. One feature of P. falciparum-parasitized erythrocytes (pRBC) leading to…”
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A powerful machine learning approach to identify interactions of differentially abundant gut microbial subsets in patients with metastatic and non-metastatic pancreatic cancer by Villani, Annacandida, Fontana, Andrea, Panebianco, Concetta, Ferro, Carmelapia, Copetti, Massimiliano, Pavlovic, Radmila, Drago, Denise, Fiorentini, Carla, Terracciano, Fulvia, Bazzocchi, Francesca, Canistro, Giuseppe, Pisati, Federica, Maiello, Evaristo, Latiano, Tiziana Pia, Perri, Francesco, Pazienza, Valerio

“…Pancreatic cancer has a dismal prognosis, as it is often diagnosed at stage IV of the disease and is characterized by metastatic spread. Gut microbiota and its…”
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Treatment with the Bacterial Toxin CNF1 Selectively Rescues Cognitive and Brain Mitochondrial Deficits in a Female Mouse Model of Rett Syndrome Carrying a MeCP2-Null Mutation by Urbinati, Chiara, Cosentino, Livia, Germinario, Elena Angela Pia, Valenti, Daniela, Vigli, Daniele, Ricceri, Laura, Laviola, Giovanni, Fiorentini, Carla, Vacca, Rosa Anna, Fabbri, Alessia, De Filippis, Bianca

“…Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked gene and a major cause of intellectual disability in females. No cure…”
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The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study by Fabbri, Alessia, Travaglione, Sara, Maroccia, Zaira, Guidotti, Marco, Pierri, Ciro Leonardo, Primiano, Guido, Servidei, Serenella, Loizzo, Stefano, Fiorentini, Carla

“…The protein toxin cytotoxic necrotizing factor 1 (CNF1), which acts on the Rho GTPases that are key regulators of the actin cytoskeleton, is emerging as a…”
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CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease by Loizzo, Stefano, Rimondini, Roberto, Travaglione, Sara, Fabbri, Alessia, Guidotti, Marco, Ferri, Alberto, Campana, Gabriele, Fiorentini, Carla

“…Overexpression of pro-inflammatory cytokines and cellular energy failure are associated with neuroinflammatory disorders, such as Alzheimer's disease…”
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The Bacterial Toxin CNF1 Protects Human Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine-Induced Cell Damage: The Hypothesis of CNF1-Promoted Autophagy as an Antioxidant Strategy by Travaglione, Sara, Loizzo, Stefano, Vona, Rosa, Ballan, Giulia, Rivabene, Roberto, Giordani, Danila, Guidotti, Marco, Dupuis, Maria Luisa, Maroccia, Zaira, Baiula, Monica, Rimondini, Roberto, Campana, Gabriele, Fiorentini, Carla

“…Several chronic neuroinflammatory diseases, including Parkinson's disease (PD), have the so-called 'redox imbalance' in common, a dynamic system modulated by…”
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The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells by Gall-Mas, Laura, Fabbri, Alessia, Namini, Martin R J, Givskov, Michael, Fiorentini, Carla, Krejsgaard, Thorbjørn

“…Cytotoxic necrotizing factor 1 (CNF1) is a bacterial protein toxin primarily expressed by pathogenic strains, causing extraintestinal infections. The toxin is…”
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Enhancement of learning and memory after activation of cerebral Rho GTPases by Diana, Giovanni, Valentini, Giovanni, Travaglione, Sara, Falzano, Loredana, Pieri, Massimo, Zona, Cristina, Meschini, Stefania, Fabbri, Alessia, Fiorentini, Carla

“…The mechanism whereby the morphology and connectivity of the dendritic tree is regulated depends on an actin dynamics that, in turn, is controlled by Rho…”
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The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine by Paganelli, Francesca, Chiarini, Francesca, Palmieri, Annalisa, Martinelli, Marcella, Sena, Paola, Bertacchini, Jessika, Roncucci, Luca, Cappellini, Alessandra, Martelli, Alberto M, Bonucci, Massimo, Fiorentini, Carla, Hammarberg Ferri, Ivano

“…The AHCC standardized extract of cultured mycelia, and the standardized extract of stem, trademarked as ETAS, are well known supplements with immunomodulatory…”
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CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice by Travaglione, Sara, Ballan, Giulia, Fortuna, Andrea, Ferri, Alberto, Guidotti, Marco, Campana, Gabriele, Fiorentini, Carla, Loizzo, Stefano

“…Epilepsy, one of the most common conditions affecting the brain, is characterized by neuroplasticity and brain cell energy defects. In this work, we…”
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Cnf1 Variants Endowed with the Ability to Cross the Blood-Brain Barrier: A New Potential Therapeutic Strategy for Glioblastoma by Colarusso, Andrea, Maroccia, Zaira, Parrilli, Ermenegilda, Germinario, Elena Angela Pia, Fortuna, Andrea, Loizzo, Stefano, Ricceri, Laura, Tutino, Maria Luisa, Fiorentini, Carla, Fabbri, Alessia

“…Among gliomas, primary tumors originating from glial cells, glioblastoma (GBM) identified as WHO grade IV glioma, is the most common and aggressive malignant…”
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The cytotoxic necrotizing factor 1 from E. coli: a janus toxin playing with cancer regulators by Fabbri, Alessia, Travaglione, Sara, Ballan, Giulia, Loizzo, Stefano, Fiorentini, Carla

“…Certain strains of Escherichia coli have been indicated as a risk factor for colon cancer. E. coli is a normal inhabitant of the human intestine that becomes…”
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Integrated Cancer Treatment in the Course of Metastatic Pancreatic Cancer: Complete Resolution in 2 Cases by Bonucci, Massimo, Pastore, Carlo, Ferrera, Vincenzo, Fiorentini, Carla, Fabbri, Alessia

“…Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases…”
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