Search Results - "FINSTERBUSCH, Katja"

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection by Bradley, Konrad C., Finsterbusch, Katja, Schnepf, Daniel, Crotta, Stefania, Llorian, Miriam, Davidson, Sophia, Fuchs, Serge Y., Staeheli, Peter, Wack, Andreas

“…Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target…”
Get full text

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation by Crotta, Stefania, Villa, Matteo, Major, Jack, Finsterbusch, Katja, Llorian, Miriam, Carmeliet, Peter, Buescher, Joerg, Wack, Andreas

“…Epithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined…”
Get full text

SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies by Ng, Kevin W, Faulkner, Nikhil, Finsterbusch, Katja, Wu, Mary, Harvey, Ruth, Hussain, Saira, Greco, Maria, Liu, Yafei, Kjaer, Svend, Swanton, Charles, Gandhi, Sonia, Beale, Rupert, Gamblin, Steve J, Cherepanov, Peter, McCauley, John, Daniels, Rodney, Howell, Michael, Arase, Hisashi, Wack, Andreas, Bauer, David L V, Kassiotis, George

“…Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic…”
Get more information

Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons by Nair, Sharmila, Michaelsen-Preusse, Kristin, Finsterbusch, Katja, Stegemann-Koniszewski, Sabine, Bruder, Dunja, Grashoff, Martina, Korte, Martin, Köster, Mario, Kalinke, Ulrich, Hauser, Hansjörg, Kröger, Andrea

“…The innate immune system protects cells against invading viral pathogens by the auto- and paracrine action of type I interferon (IFN). In addition, the…”
Get full text

IRF-1 Expression Is Essential for Natural Killer Cells to Suppress Metastasis by KSIENZYK, Antje, NEUMANN, Berit, NANDAKUMAR, Ramya, FINSTERBUSCH, Katja, GRASHOFF, Martina, ZAWATZKY, Rainer, BERNHARDT, Gunter, HAUSER, Hansjörg, KRÖGER, Andrea

“…IFN-γ promotes tumoral immune surveillance, but its involvement in controlling metastases is less clear. Using a mouse model of pulmonary metastases, we show…”
Get full text

Down-RANKing the Threat of HSV-1: RANKL Upregulates MHC-Class-I-Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection by Finsterbusch, Katja, Piguet, Vincent

“…Herpes simplex virus (HSV-1) is a major cause of viral skin infection in humans. Klenner and colleagues now show that the epidermal receptor activator of NFκB…”
Get full text

Endothelial AHR activity prevents lung barrier disruption in viral infection by Major, Jack, Crotta, Stefania, Finsterbusch, Katja, Chakravarty, Probir, Shah, Kathleen, Frederico, Bruno, D’Antuono, Rocco, Green, Mary, Meader, Lucy, Suarez-Bonnet, Alejandro, Priestnall, Simon, Stockinger, Brigitta, Wack, Andreas

“…Disruption of the lung endothelial–epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and…”
Get full text

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza by Rappe, Julie C F, Finsterbusch, Katja, Crotta, Stefania, Mack, Matthias, Priestnall, Simon L, Wack, Andreas

“…Cytokine-mediated immune-cell recruitment and inflammation contribute to protection in respiratory virus infection. However, uncontrolled inflammation and the…”
Get full text

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses by Weber, Elvira, Finsterbusch, Katja, Lindquist, Richard, Nair, Sharmila, Lienenklaus, Stefan, Gekara, Nelson O, Janik, Dirk, Weiss, Siegfried, Kalinke, Ulrich, Överby, Anna K, Kröger, Andrea

“…Vector-borne flaviviruses, such as tick-borne encephalitis virus (TBEV), West Nile virus, and dengue virus, cause millions of infections in humans. TBEV causes…”
Get full text

Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4+ T Cells by Shimauchi, Takatoshi, Caucheteux, Stephan, Finsterbusch, Katja, Turpin, Jocelyn, Blanchet, Fabien, Ladell, Kristin, Triantafilou, Kathy, Czubala, Magdalena, Tatsuno, Kazuki, Easter, Tammy, Ahmed, Zahra, Bayliss, Rebecca, Hakobyan, Svetlana, Price, David A., Tokura, Yoshiki, Piguet, Vincent

“…Human T-cell leukemia virus type 1 (HTLV-1) propagates within and between individuals via cell-to-cell transmission, and primary infection typically occurs…”
Get full text

Cell-to-cell contact with HTLV-1-infected T cell reduces dendritic cell immune functions and contributes to infection in trans by Shimauchi, Takatoshi, Caucheteux, Stephan, Turpin, Jocelyn, Finsterbusch, Katja, Bangham, Charles R.M, Tokura, Yoshiki, Piguet, Vincent

Get full text

Hepatitis C Virus Replication in Mouse Cells Is Restricted by IFN-Dependent and -Independent Mechanisms by Nandakumar, Ramya, Finsterbusch, Katja, Lipps, Christoph, Neumann, Berit, Grashoff, Martina, Nair, Sharmila, Hochnadel, Inga, Lienenklaus, Stefan, Wappler, Ilka, Steinmann, Eike, Hauser, Hansjörg, Pietschmann, Thomas, Kröger, Andrea

“…Background & Aims Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50%…”
Get full text

Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TMBIM4 safeguards IgG1 + GC B cell-positive selection by Zhang, Lingling, Toboso-Navasa, Amparo, Gunawan, Arief, Camara, Abdouramane, Nakagawa, Rinako, Finsterbusch, Katja, Chakravarty, Probir, Newman, Rebecca, Zhang, Yang, Eilers, Martin, Wack, Andreas, Tolar, Pavel, Toellner, Kai-Michael, Calado, Dinis Pedro

“…The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers…”
Get more information

TGFβ Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells by Czubala, Magdalena A., Finsterbusch, Katja, Ivory, Matthew O., Mitchell, J. Paul, Ahmed, Zahra, Shimauchi, Takatoshi, Karoo, Richard O.S., Coulman, Sion A., Gateley, Christopher, Birchall, James C., Blanchet, Fabien P., Piguet, Vincent

“…Sterile alpha motif (SAM) and histidine-aspartic (HD) domains protein 1 (SAMHD1) was previously identified as a critical post-entry restriction factor to HIV-1…”
Get full text

183 by Nair, Sharmila, Finsterbusch, Katja, Hauser, Hansjörg, Kröger, Andrea

Get full text

183: Interferon regulatory factor-1 protects mice from lethal neuropathogenesis by type-I IFN-independent local antiviral effects by Nair, Sharmila, Finsterbusch, Katja, Hauser, Hansjörg, Kröger, Andrea

“…Interferon regulatory factor-1 (IRF-1) is a transcription factor that functions downstream of pathogen recognition receptor signalling. It has been implicated…”
Get full text

276 : Type I interferon protects against lethal Langat virus infection by Weber, Elvira, Finsterbusch, Katja, Lindquist, Richard, Kröger, Andrea, Överby, Anna

“…Flaviviruses e.g., West Nile virus, dengue virus and tick borne encephalitis virus (TBEV) are globally distributed human pathogens that cause millions of…”
Get full text

276 by Weber, Elvira, Finsterbusch, Katja, Lindquist, Richard, Kröger, Andrea, Överby, Anna

Get full text

Mouse CMV infection delays antibody class switch upon an unrelated virus challenge by Marandu, Thomas F., Finsterbusch, Katja, Kröger, Andrea, Čičin-Šain, Luka

“…Poor immune protection upon vaccination is a critical determinant of immunosenescence. Latent Cytomegalovirus (CMV) infection has been associated with poor…”
Get full text

Type I interferon protects against lethal Langat virus infection by Weber, Elvira, Finsterbusch, Katja, Lindqvist, Richard, Kroger, Andrea, Överby, Anna

Get full text