Search Results - "FINOCCHIARO, Gaetano"

Milan 2020: COVID-19, neuro-oncology and much more by Finocchiaro, Gaetano

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Clonal evolution of glioblastoma under therapy by Wang, Jiguang, Cazzato, Emanuela, Ladewig, Erik, Frattini, Veronique, Rosenbloom, Daniel I S, Zairis, Sakellarios, Abate, Francesco, Liu, Zhaoqi, Elliott, Oliver, Shin, Yong-Jae, Lee, Jin-Ku, Lee, In-Hee, Park, Woong-Yang, Eoli, Marica, Blumberg, Andrew J, Lasorella, Anna, Nam, Do-Hyun, Finocchiaro, Gaetano, Iavarone, Antonio, Rabadan, Raul

“…Raul Rabadan, Antonio Iavarone, Gaetano Finocchiaro, Do-Hyun Nam and colleagues analyze longitudinal genomic and transcriptomic data from 114 patients with…”
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The integrated landscape of driver genomic alterations in glioblastoma by Frattini, Veronique, Trifonov, Vladimir, Chan, Joseph Minhow, Castano, Angelica, Lia, Marie, Abate, Francesco, Keir, Stephen T, Ji, Alan X, Zoppoli, Pietro, Niola, Francesco, Danussi, Carla, Dolgalev, Igor, Porrati, Paola, Pellegatta, Serena, Heguy, Adriana, Gupta, Gaurav, Pisapia, David J, Canoll, Peter, Bruce, Jeffrey N, McLendon, Roger E, Yan, Hai, Aldape, Ken, Finocchiaro, Gaetano, Mikkelsen, Tom, Privé, Gilbert G, Bigner, Darell D, Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio

“…Anna Lasorella, Raul Rabadan, Antonio Iavarone and colleagues report an integrated analysis of genomic alterations in glioblastoma. They identify and…”
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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth by Hu, Baoli, Wang, Qianghu, Wang, Y. Alan, Hua, Sujun, Sauvé, Charles-Etienne Gabriel, Ong, Derrick, Lan, Zheng D., Chang, Qing, Ho, Yan Wing, Monasterio, Marta Moreno, Lu, Xin, Zhong, Yi, Zhang, Jianhua, Deng, Pingna, Tan, Zhi, Wang, Guocan, Liao, Wen-Ting, Corley, Lynda J., Yan, Haiyan, Zhang, Junxia, You, Yongping, Liu, Ning, Cai, Linbo, Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Spring, Denise J., Hu, Jian, Sulman, Erik P., Fuller, Gregory N., Chin, Lynda, Verhaak, Roeland G.W., DePinho, Ronald A.

“…Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these…”
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MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives by Bruzzone, Maria Grazia, Finocchiaro, Gaetano, Gioppo, Andrea, Aquino, Domenico, Cuccarini, Valeria

“…Pseudophenomena, that is, imaging alterations due to therapy rather than tumor evolution, have an important impact on the management of glioma patients and the…”
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A Randomized Phase II Trial (TAMIGA) Evaluating the Efficacy and Safety of Continuous Bevacizumab Through Multiple Lines of Treatment for Recurrent Glioblastoma by Brandes, Alba A., Gil‐Gil, Miguel, Saran, Frank, Carpentier, Antoine F., Nowak, Anna K., Mason, Warren, Zagonel, Vittorina, Dubois, François, Finocchiaro, Gaetano, Fountzilas, George, Cernea, Dana Michaela, Chinot, Oliver, Anghel, Rodica, Ghiringhelli, Francois, Beauchesne, Patrick, Lombardi, Giuseppe, Franceschi, Enrico, Makrutzki, Martina, Mpofu, Chiedzo, Urban, Hans‐Joerg, Pichler, Josef

“…Background We assessed the efficacy and safety of bevacizumab (BEV) through multiple lines in patients with recurrent glioblastoma who had progressed after…”
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High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient by Anghileri, Elena, Di Ianni, Natalia, Paterra, Rosina, Langella, Tiziana, Zhao, Junfei, Eoli, Marica, Patanè, Monica, Pollo, Bianca, Cuccarini, Valeria, Iavarone, Antonio, Rabadan, Raul, Finocchiaro, Gaetano, Pellegatta, Serena

“…Background Glioblastomas (GBMs) in patients harboring somatic or germinal mutations of mismatch-repair (MMR) genes exhibit a hypermutable phenotype. Here, we…”
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Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma by FAVARO, Rebecca, APPOLLONI, Irene, MALATESTA, Paolo, NICOLIS, Silvia K, PELLEGATTA, Serena, SANGA, Alexandra Badiola, PAGELLA, Pierfrancesco, GAMBINI, Eleonora, PISATI, Federica, OTTOLENGHI, Sergio, FOTI, Maria, FINOCCHIARO, Gaetano

“…The stem cell-determining transcription factor Sox2 is required for the maintenance of normal neural stem cells. In this study, we investigated the requirement…”
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Advanced neuroimaging studies: a patient-centered revolution by Berzero, Giulia, Mansi, Luigi, Finocchiaro, Gaetano

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A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways by Huang, Tianzhi, Alvarez, Angel A., Pangeni, Rajendra P., M. Horbinski, Craig, Lu, Songjian, Kim, Sung-Hak, James, C. David, J. Raizer, Jeffery, A. Kessler, John, Brenann, Cameron W., Sulman, Erik P., Finocchiaro, Gaetano, Tan, Ming, Nishikawa, Ryo, Lu, Xinghua, Nakano, Ichiro, Hu, Bo, Cheng, Shi-Yuan

“…Molecularly defined subclassification is associated with phenotypic malignancy of glioblastoma (GBM). However, current understanding of the molecular basis of…”
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A radial glia gene marker, fatty acid binding protein 7 (FABP7), is involved in proliferation and invasion of glioblastoma cells by De Rosa, Antonella, Pellegatta, Serena, Rossi, Marco, Tunici, Patrizia, Magnoni, Letizia, Speranza, Maria Carmela, Malusa, Federico, Miragliotta, Vincenzo, Mori, Elisa, Finocchiaro, Gaetano, Bakker, Annette

“…Glioblastoma multiforme (GBM) is among the most deadly cancers. A number of studies suggest that a fraction of tumor cells with stem cell features (Glioma…”
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The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype by DE BACCO, Francesca, CASANOVA, Elena, PATANE, Monica, MADERNA, Emanuela, POLLO, Bianca, COMOGLIO, Paolo M, FINOCCHIARO, Gaetano, BOCCACCIO, Carla, MEDICO, Enzo, PELLEGATTA, Serena, ORZAN, Francesca, ALBANO, Raffaella, LURAGHI, Paolo, REATO, Gigliola, D'AMBROSIO, Antonio, PORRATI, Paola

“…The existence of treatment-resistant cancer stem cells contributes to the aggressive phenotype of glioblastoma. However, the molecular alterations that drive…”
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Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas by De Bacco, Francesca, Orzan, Francesca, Crisafulli, Giovanni, Prelli, Marta, Isella, Claudio, Casanova, Elena, Albano, Raffaella, Reato, Gigliola, Erriquez, Jessica, D’Ambrosio, Antonio, Panero, Mara, Dall’Aglio, Carmine, Casorzo, Laura, Cominelli, Manuela, Pagani, Francesca, Melcarne, Antonio, Zeppa, Pietro, Altieri, Roberto, Morra, Isabella, Cassoni, Paola, Garbossa, Diego, Cassisa, Anna, Bartolini, Alice, Pellegatta, Serena, Comoglio, Paolo M., Finocchiaro, Gaetano, Poliani, Pietro L., Boccaccio, Carla

“…Glioblastoma (GBM) is known as an intractable, highly heterogeneous tumor encompassing multiple subclones, each supported by a distinct glioblastoma stem cell…”
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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma by De Bacco, Francesca, Orzan, Francesca, Erriquez, Jessica, Casanova, Elena, Barault, Ludovic, Albano, Raffaella, D’Ambrosio, Antonio, Bigatto, Viola, Reato, Gigliola, Patanè, Monica, Pollo, Bianca, Kuesters, Geoffrey, Dell’Aglio, Carmine, Casorzo, Laura, Pellegatta, Serena, Finocchiaro, Gaetano, Comoglio, Paolo M., Boccaccio, Carla

“…In glioblastoma (GBM), the most frequent and lethal brain tumor, therapies suppressing recurrently altered signaling pathways failed to extend survival…”
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MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells by De Bacco, Francesca, D'Ambrosio, Antonio, Casanova, Elena, Orzan, Francesca, Neggia, Roberta, Albano, Raffaella, Verginelli, Federica, Cominelli, Manuela, Poliani, Pietro L, Luraghi, Paolo, Reato, Gigliola, Pellegatta, Serena, Finocchiaro, Gaetano, Perera, Timothy, Garibaldi, Elisabetta, Gabriele, Pietro, Comoglio, Paolo M, Boccaccio, Carla

“…Glioblastoma (GBM) contains stem‐like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal…”
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Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas by PELLEGATTA, Serena, POLIANI, Pietro Luigi, BRUZZONE, Maria Grazia, FINOCCHIARO, Gaetano, CORNO, Daniela, MENGHI, Francesca, GHIELMETTI, Francesco, SUAREZ-MERINO, Blanca, CALDERA, Valentina, NAVA, Sara, RAVANINI, Maria, FACCHETTI, Fabio

“…Cancer stem-like cells (CSC) could be a novel target for cancer therapy, including dendritic cell (DC) immunotherapy. To address this, we developed experiments…”
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Survival gain in glioblastoma patients treated with dendritic cell immunotherapy is associated with increased NK but not CD8+ T cell activation in the presence of adjuvant temozolomide by Pellegatta, Serena, Eoli, Marica, Cuccarini, Valeria, Anghileri, Elena, Pollo, Bianca, Pessina, Sara, Frigerio, Simona, Servida, Maura, Cuppini, Lucia, Antozzi, Carlo, Cuzzubbo, Stefania, Corbetta, Cristina, Paterra, Rosina, Acerbi, Francesco, Ferroli, Paolo, DiMeco, Francesco, Fariselli, Laura, Parati, Eugenio A., Bruzzone, Maria Grazia, Finocchiaro, Gaetano

“…In a two-stage phase II study, 24 patients with first diagnosis of glioblastoma (GBM) were treated with dendritic cell (DC) immunotherapy associated to…”
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Immunotherapy response assessment in neuro-oncology: a report of the RANO working group by Okada, Hideho, Prof, Weller, Michael, Prof, Huang, Raymond, MD, Finocchiaro, Gaetano, MD, Gilbert, Mark R, MD, Wick, Wolfgang, Prof, Ellingson, Benjamin M, PhD, Hashimoto, Naoya, MD, Pollack, Ian F, Prof, Brandes, Alba A, MD, Franceschi, Enrico, MD, Herold-Mende, Christel, Prof, Nayak, Lakshmi, MD, Panigrahy, Ashok, MD, Pope, Whitney B, MD, Prins, Robert, PhD, Sampson, John H, Prof, Wen, Patrick Y, Prof, Reardon, David A, MD

“…Summary Immunotherapy is a promising area of therapy in patients with neuro-oncological malignancies. However, early-phase studies show unique challenges…”
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Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature by Elena, Anghileri, Melina, Castiglione, Raffaele, Nunziata, Carlo, Boffano, Vittoria, Nazzi, Francesco, Acerbi, Gaetano, Finocchiaro, Marica, Eoli

“…Glioblastoma (GBM) are high-grade gliomas that severely impact on overall survival (OS). GBM cell motility and the breakdown of the blood–brain barrier could…”
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Targeting Post-Translational Modifications to Improve Combinatorial Therapies in Breast Cancer: The Role of Fucosylation by Antonarelli, Gabriele, Pieri, Valentina, Porta, Francesca Maria, Fusco, Nicola, Finocchiaro, Gaetano, Curigliano, Giuseppe, Criscitiello, Carmen

“…Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate…”
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