Search Results - "FINNEY, LYDIA"

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon by Finney, Lydia J., Glanville, Nicholas, Farne, Hugo, Aniscenko, Julia, Fenwick, Peter, Kemp, Samuel V., Trujillo-Torralbo, Maria-Belen, Loo, Su Ling, Calderazzo, Maria Adelaide, Wedzicha, Jadwiga A., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L., Singanayagam, Aran

“…The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with…”
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Selected updates on chronic obstructive pulmonary disease by Mah, Jordina, Ritchie, Andrew I, Finney, Lydia J

“…Chronic obstructive pulmonary disease (COPD) is preventable disease and yet it remains the third greatest cause of death worldwide. This review focuses on…”
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Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease by Singanayagam, Aran, Footitt, Joseph, Marczynski, Matthias, Radicioni, Giorgia, Cross, Michael T, Finney, Lydia J, Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria, Zhu, Jie, Aniscenko, Julia, Clarke, Thomas B, Molyneaux, Philip L, Bartlett, Nathan W, Moffatt, Miriam F, Cookson, William O, Wedzicha, Jadwiga, Evans, Christopher M, Boucher, Richard C, Kesimer, Mehmet, Lieleg, Oliver, Mallia, Patrick, Johnston, Sebastian L

“…The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a…”
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Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease by Singanayagam, Aran, Glanville, Nicholas, Cuthbertson, Leah, Bartlett, Nathan W, Finney, Lydia J, Turek, Elena, Bakhsoliani, Eteri, Calderazzo, Maria Adelaide, Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, James, Phillip L, Fenwick, Peter, Kemp, Samuel V, Clarke, Thomas B, Wedzicha, Jadwiga A, Edwards, Michael R, Moffatt, Miriam, Cookson, William O, Mallia, Patrick, Johnston, Sebastian L

“…Bacterial infection commonly complicates inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD). The mechanisms of increased…”
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Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy by Dodani, Sheel C, Domaille, Dylan W, Nam, Christine I, Miller, Evan W, Finney, Lydia A, Vogt, Stefan, Chang, Christopher J

“…Dynamic fluxes of s-block metals like potassium, sodium, and calcium are of broad importance in cell signaling. In contrast, the concept of mobile transition…”
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Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations by Singanayagam, Aran, Glanville, Nicholas, Girkin, Jason L., Ching, Yee Man, Marcellini, Andrea, Porter, James D., Toussaint, Marie, Walton, Ross P., Finney, Lydia J., Aniscenko, Julia, Zhu, Jie, Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria Adelaide, Grainge, Chris, Loo, Su-Ling, Veerati, Punnam Chander, Pathinayake, Prabuddha S., Nichol, Kristy S., Reid, Andrew T., James, Phillip L., Solari, Roberto, Wark, Peter A. B., Knight, Darryl A., Moffatt, Miriam F., Cookson, William O., Edwards, Michael R., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L.

“…Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary disease (COPD) exacerbations and increase pneumonia risk, through…”
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Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors by Finney, Lydia A., O'Halloran, Thomas V.

“…The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can…”
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An Iron-Activated Citrate Transporter, MtMATE67, Is Required for Symbiotic Nitrogen Fixation by Kryvoruchko, Igor S., Routray, Pratyush, Sinharoy, Senjuti, Torres-Jerez, Ivone, Tejada-Jiménez, Manuel, Finney, Lydia A., Nakashima, Jin, Pislariu, Catalina I., Benedito, Vagner A., González-Guerrero, Manuel, Roberts, Daniel M., Udvardi, Michael K.

“…Iron (Fe) is an essential micronutrient for symbiotic nitrogen fixation in legume nodules, where it is required for the activity of bacterial nitrogenase,…”
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Accelerated Lung Function Decline and Mucus-Microbe Evolution in Chronic Obstructive Pulmonary Disease by Meldrum, Oliver W, Donaldson, Gavin C, Narayana, Jayanth Kumar, Xaverius Ivan, Fransiskus, Jaggi, Tavleen K, Mac Aogáin, Micheál, Finney, Lydia J, Allinson, James P, Wedzicha, Jadwiga A, Chotirmall, Sanjay H

“…Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung…”
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Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease by Finney, Lydia J, Belchamber, Kylie B R, Fenwick, Peter S, Kemp, Samuel V, Edwards, Michael R, Mallia, Patrick, Donaldson, Gavin, Johnston, Sebastian L, Donnelly, Louise E, Wedzicha, Jadwiga A

“…Human rhinovirus (HRV) is a common cause of chronic obstructive pulmonary disease (COPD) exacerbations. Secondary bacterial infection is associated with more…”
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Antiviral immunity is impaired in COPD patients with frequent exacerbations by Singanayagam, Aran, Loo, Su-Ling, Calderazzo, Maria, Finney, Lydia J, Trujillo Torralbo, Maria-Belen, Bakhsoliani, Eteri, Girkin, Jason, Veerati, Punnam, Pathinayake, Prabuddha S, Nichol, Kristy S, Reid, Andrew, Footitt, Joseph, Wark, Peter A B, Grainge, Christopher L, Johnston, Sebastian L, Bartlett, Nathan W, Mallia, Patrick

“…Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) subgroup requiring better treatment options. The aim of this…”
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A Double-Blind, Randomized, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable Chronic Obstructive Pulmonary Disease by Allinson, James P, Vlies, Ben H, Brill, Simon E, Law, Martin, Burnside, Girvan, Finney, Lydia J, Alves-Moreira, Luana, Donaldson, Gavin C, Calverley, Peter M A, Walker, Paul P, Wedzicha, Jadwiga A

“…Chronic obstructive pulmonary disease (COPD) exacerbations are a major cause of morbidity and mortality, and preventing them is a key treatment target…”
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Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans by Sharma, Anuj Kumar, Finney, Lydia, Vogt, Stefan, Vatamaniuk, Olena K, Kim, Sungjin

“…The chronic exposure of humans to the toxic metal cadmium (Cd), either occupational or from food and air, causes various diseases, including neurodegenerative…”
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Reply to Martinez-Garcia et al. and to Wang et al by Allinson, James P, Vlies, Ben H, Brill, Simon E, Law, Martin, Burnside, Girvan, Finney, Lydia J, Alves-Moreira, Luana, Calverley, Peter M A, Walker, Paul P, Wedzicha, Jadwiga A

“…Allinson et al respond to comments on their article on long-term doxycycline therapy for stable chronic obstructive pulmonary disease. They state that by…”
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Is it safe to prescribe benzodiazepines or opioids for dyspnoea in interstitial lung disease? by Finney, Lydia J

“…http://ow.ly/SCTl30o9bWq…”
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Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae by Finney, Lydia J, Ritchie, Andrew, Pollard, Elizabeth, Johnston, Sebastian L, Mallia, Patrick

“…Bacterial infection of the lower respiratory tract in chronic obstructive pulmonary disease (COPD) patients is common both in stable patients and during acute…”
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Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo by Das, Archita, Sudhahar, Varadarajan, Chen, Gin-Fu, Kim, Ha Won, Youn, Seock-Won, Finney, Lydia, Vogt, Stefan, Yang, Jay, Kweon, Junghun, Surenkhuu, Bayasgalan, Ushio-Fukai, Masuko, Fukai, Tohru

“…Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1…”
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Targeted Retreatment of Incompletely Recovered Chronic Obstructive Pulmonary Disease Exacerbations with Ciprofloxacin. A Double-Blind, Randomized, Placebo-controlled, Multicenter, Phase III Clinical Trial by Ritchie, Andrew I, Brill, Simon E, Vlies, Ben H, Finney, Lydia J, Allinson, James P, Alves-Moreira, Luana, Wiseman, Dexter J, Walker, Paul P, Baker, Emma, Elkin, Sarah L, Mallia, Patrick, Law, Martin, Donaldson, Gavin C, Calverley, Peter M A, Wedzicha, Jadwiga A

“…Chronic obstructive pulmonary disease (COPD) exacerbations are prone to nonrecovery, but there are no data about the effectiveness of retreatment for these…”
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Metabolism of Selenite in Human Lung Cancer Cells: X-Ray Absorption and Fluorescence Studies by Weekley, Claire M, Aitken, Jade B, Vogt, Stefan, Finney, Lydia A, Paterson, David J, de Jonge, Martin D, Howard, Daryl L, Witting, Paul K, Musgrave, Ian F, Harris, Hugh H

“…Selenite is an inorganic form of selenium that has a cytotoxic effect against several human cancer cell lines: one or more selenite metabolites are considered…”
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Preparing adherent cells for X-ray fluorescence imaging by chemical fixation by Finney, Lydia A, Jin, Qiaoling

“…X-ray fluorescence imaging allows us to non-destructively measure the spatial distribution and concentration of multiple elements simultaneously over large or…”
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