Search Results - "FINGERT, Howard J"

Assessing proarrhythmic potential of drugs when optimal studies are infeasible by Rock, Edwin P., MD, PhD, Finkle, John, MD, Fingert, Howard J., MD, Booth, Brian P., PhD, Garnett, Christine E., PharmD, Grant, Stephen, MD, Justice, Robert L., MD, Kovacs, Richard J., MD, Kowey, Peter R., MD, Rodriguez, Ignacio, MD, Sanhai, Wendy R., PhD, Strnadova, Colette, PhD, Targum, Shari L., MD, Tsong, Yi, PhD, Uhl, Kathleen, MD, Stockbridge, Norman, MD, PhD

“…Assessing the potential for a new drug to cause life-threatening arrhythmias is now an integral component of premarketing safety assessment. International…”
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Expanding Role of Data Science and Bioinformatics in Drug Discovery and Development by Fingert, Howard J.

“…Numerous barriers have been identified which detract from successful applications of clinical trial data and platforms. Despite the challenges, opportunities…”
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Deamination of Glutamine is a Prerequisite for Optimal Asparagine Deamination by Asparaginases In Vivo (CCG-1961) by PANOSYAN, Eduard H, GRIGORYAN, Rita S, AVRAMIS, Ioannis A, SEIBEL, Nita L, GAYNON, Paul S, SIEGEL, Stuart E, FINGERT, Howard J, AVRAMIS, Vassilios I

“…Background: Glutamine (Gln) deamination by asparaginase (ASNase) appears to contribute in the decrease of serum asparagine (Asn) levels and enhance leukemic…”
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Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development by Curigliano, Giuseppe, Spitaleri, Gianluca, Fingert, Howard J, de Braud, Filippo, Sessa, Cristiana, Loh, Elwyn, Cipolla, Carlo, De Pas, Tommaso, Goldhirsch, Aron, Shah, Rashmi

“…Abstract The goal of drug development is to define potential risks and benefits of new therapies. Assessment of new drugs for their potential to alter cardiac…”
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Cardiac safety, risk management, and oncology drug development by Fingert, Howard J, Varterasian, Mary L

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In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle by MOSSERI, M, FINGERT, H. J, VARTICOVSKI, L, CHOKSHI, S, ISNER, J. M

“…5-Fluorouracil (5-FU) is a commonly employed chemotherapeutic agent. Among the various toxicities associated with 5-FU, cardiovascular toxicity, consisting…”
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Brain natriuretic peptide: potential adjunct for cardiac risk assessment and management during treatment with experimental anticancer agents by Varterasian, Mary L, Meyer, Mark B, Pressler, Milton L, Fingert, Howard J, LoRusso, Patricia M

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Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up by THOR, A. D, SCHWARTZ, L. H, WOOD, W. C, KOERNER, F. C, EDGERTON, S. M, SKATES, S. J, YIN, S, MCKENZIE, S. J, PANICALI, D. L, MARKS, P. J, FINGERT, H. J

“…Various monoclonal antibodies reactive with protooncogene products or tumor-associated antigens have been utilized to investigate breast carcinoma biology or…”
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Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents by FINGERT, H. J, CHANG, J. D, PARDEE, A. B

“…Human tumor cells, like rodent cells, are sensitive to effects of methylxanthines (MEX) on lethality, cell cycle delays, and chromosome aberrations after DNA…”
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Rapid growth of human cancer cells in a mouse model with fibrin clot subrenal capsule assay by FINGERT, H. J, ZUYING CHEN, MIZRAHI, N, GAJEWSKI, W. H, BAMBERG, M. P, KRADIN, R. L

“…Rapid in vivo growth of cultured human cancer or leukemia cells was achieved by implantation into the subrenal capsule of mice. A solid structure, necessary…”
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Cyclin E, a potential prognostic marker for breast cancer by KEYOMARSI, K, O'LEARY, N, MOLNAR, G, LEES, E, FINGERT, H. J, PARDEE, A. B

“…A fundamental cause of cancer is changed properties of genetic material, which may deregulate normal development of the tissue or provide selective growth…”
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Drug-induced QTc interval prolongation : A proposal towards an efficient and safe anticancer drug development. Commentary by JONGE, Maja De, VERWEIJ, Jaap, GOLDHIRSCH, Aron, SHAH, Rashmi, CURIGLIANO, Giuseppe, SPITALERI, Gianluca, FINGERT, Howard J, DE BRAUD, Filippo, SESSA, Cristiana, LOH, Elwyn, CIPOLLA, Carlo, DE PAS, Tommaso

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Pharmacokinetics and Pharmacodynamics of Three Asparaginases in Pediatric Patients with Higher Risk Acute Lymphoblastic Leukemia: A Report from CCG-1961 by Panosyan, Eduard H., Seibel, Nita L., Grigoryan, Rita S., Avramis, Ioannis A., Jaques, Jon D., Ettinger, Lawrence J., Gaynon, Paul S., Sather, Harland N., Franklin, Janet, Cecilia, Fu, Siegel, Stuart E., Fingert, Howard J., Avramis, Vassilios I.

“…Deamination of asparagine (Asn) and glutamine (Gln) by asparaginase (ASNase) induces apoptosis of ALL lymphoblasts, which lack ability to synthesize Asn…”
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Incapacitating autonomic neuropathy precipitated by taxol by Jerian, S M, Sarosy, G A, Link, Jr, C J, Fingert, H J, Reed, E, Kohn, E C

“…Taxol is one of the more significant advances in cancer chemotherapy in the last 10-15 years with a 30-50% response rate in both breast and ovarian cancers…”
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Predictive value of the fluorescent cytoprint assay (FCA): a retrospective correlation study of in vitro chemosensitivity and individual responses to chemotherapy by Leone, L A, Meitner, P A, Myers, T J, Grace, W R, Gajewski, W H, Fingert, H J, Rotman, B

“…The potential clinical usefulness of the fluorescent cytoprint assay (FCA) was assessed retrospectively in 73 cancer patients by correlating individual tumor…”
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Implantation of human meningiomas into the subrenal capsule of the nude mouse. A model for studies of tumor growth by Medhkour, A, Van Roey, M, Sobel, R A, Fingert, H J, Lee, J, Martuza, R L

“…To develop a reproducible in vivo model for the growth of human meningiomas, meningiomas from 16 patients were implanted into the subrenal capsule of the nude…”
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Transplantation of Human or Rodent Tumors into Cyclosporine-Treated Mice: A Feasible Model for Studies of Tumor Biology and Chemotherapy by Fingert, Howard J., Treiman, Alan, Pardee, Arthur B.

“…Total growth of transplanted human or rodent tumors in the subrenal capsule of mice was much improved by treatment with cyclosporine (CSA, cyclosporin A)…”
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In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa by FINGER, H. J, PU, A. T, CHEN, Z, GOOGE, P. B, ALLEY, M. C, PARDEE, A. B

“…Methylxanthines enhance lethality of alkylating agents in human cancer cells, a phenomenon attributed to the prevention of DNA repair. Pentoxifylline is a…”
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Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa by Fingert, H J, Kindy, R L, Pardee, A B

“…Cytotoxicity of thiotepa or doxorubicin hydrochloride in human bladder cancer cells was investigated alone and in combination with methylxanthines…”
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