Search Results - "FINEBERG, Elena"

Placentation defects are highly prevalent in embryonic lethal mouse mutants by Perez-Garcia, Vicente, Fineberg, Elena, Wilson, Robert, Murray, Alexander, Mazzeo, Cecilia Icoresi, Tudor, Catherine, Sienerth, Arnold, White, Jacqueline K., Tuck, Elizabeth, Ryder, Edward J., Gleeson, Diane, Siragher, Emma, Wardle-Jones, Hannah, Staudt, Nicole, Wali, Neha, Collins, John, Geyer, Stefan, Busch-Nentwich, Elisabeth M., Galli, Antonella, Smith, James C., Robertson, Elizabeth, Adams, David J., Weninger, Wolfgang J., Mohun, Timothy, Hemberger, Myriam

“…Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse gene knockouts cause intrauterine lethality. Analysis of these mutants has…”
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Maternal DNA Methylation Regulates Early Trophoblast Development by Branco, Miguel R., King, Michelle, Perez-Garcia, Vicente, Bogutz, Aaron B., Caley, Matthew, Fineberg, Elena, Lefebvre, Louis, Cook, Simon J., Dean, Wendy, Hemberger, Myriam, Reik, Wolf

“…Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the…”
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SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease by Garcia-Reitböck, Pablo, Anichtchik, Oleg, Bellucci, Arianna, Iovino, Mariangela, Ballini, Chiara, Fineberg, Elena, Ghetti, Bernardino, Della Corte, Laura, Spano, PierFranco, Tofaris, George K., Goedert, Michel, Spillantini, Maria Grazia

“…The pre-synaptic protein α-synuclein is the main component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson’s…”
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A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells by Chrysanthou, Stephanie, Senner, Claire E., Woods, Laura, Fineberg, Elena, Okkenhaug, Hanneke, Burge, Sarah, Perez-Garcia, Vicente, Hemberger, Myriam

“…The ten-eleven translocation (TET) proteins are well known for their role in maintaining naive pluripotency of embryonic stem cells. Here, we demonstrate that,…”
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Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis by Bowlt Blacklock, Kelly, Birand, Zeynep, Biasoli, Deborah, Fineberg, Elena, Murphy, Sue, Flack, Debs, Bass, Joyce, Di Palma, Stefano, Blackwood, Laura, McKay, Jenny, Whitbread, Trevor, Fox, Richard, Eve, Tom, Beaver, Stuart, Starkey, Mike

“…Cutaneous mast cell tumours are one of the most common canine cancers. Approximately 25% of the tumours metastasise. Activating c-kit mutations are present in…”
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A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers by Biasoli, Deborah, Compston-Garnett, Lara, Ricketts, Sally L, Birand, Zeynep, Courtay-Cahen, Celine, Fineberg, Elena, Arendt, Maja, Boerkamp, Kim, Melin, Malin, Koltookian, Michele, Murphy, Sue, Rutteman, Gerard, Lindblad-Toh, Kerstin, Starkey, Mike

“…Mast cell tumours are the most common type of skin cancer in dogs, representing a significant concern in canine health. The molecular pathogenesis is largely…”
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Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE by MAVADDAT, Nasim, PEOCK, Susan, DAVIDSON, Rosemarie, ECCLES, Diana, COLE, Trevor, COOK, Jackie, BREWER, Carole, TISCHKOWITZ, Marc, DOUGLAS, Fiona, HODGSON, Shirley, WALKER, Lisa, PORTEOUS, Mary E, FROST, Debra, MORRISON, Patrick J, SIDE, Lucy E, KENNEDY, M. John, HOUGHTON, Catherine, DONALDSON, Alan, ROGERS, Mark T, DORKINS, Huw, MIEDZYBRODZKA, Zosia, GREGORY, Helen, EASON, Jacqueline, ELLIS, Steve, BARWELL, Julian, MCCANN, Emma, MURRAY, Alex, ANTONIOU, Antonis C, EASTON, Douglas F, PLATTE, Radka, FINEBERG, Elena, EVANS, D. Gareth, IZATT, Louise, EELES, Rosalind A, ADLARD, Julian

“…Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance…”
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Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines by Wilson, Robert, McGuire, Christina, Mohun, Timothy

“…The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or…”
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Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk by Gaudet, Mia M, Kuchenbaecker, Karoline B, Vijai, Joseph, Klein, Robert J, Kirchhoff, Tomas, McGuffog, Lesley, Barrowdale, Daniel, Dunning, Alison M, Lee, Andrew, Dennis, Joe, Healey, Sue, Dicks, Ed, Soucy, Penny, Sinilnikova, Olga M, Pankratz, Vernon S, Wang, Xianshu, Eldridge, Ronald C, Tessier, Daniel C, Vincent, Daniel, Bacot, Francois, Hogervorst, Frans B L, Peock, Susan, Stoppa-Lyonnet, Dominique, Peterlongo, Paolo, Schmutzler, Rita K, Nathanson, Katherine L, Piedmonte, Marion, Singer, Christian F, Thomassen, Mads, Hansen, Thomas v O, Neuhausen, Susan L, Blanco, Ignacio, Greene, Mark H, Garber, Judith, Weitzel, Jeffrey N, Andrulis, Irene L, Goldgar, David E, D'Andrea, Emma, Caldes, Trinidad, Nevanlinna, Heli, Osorio, Ana, van Rensburg, Elizabeth J, Arason, Adalgeir, Rennert, Gad, van den Ouweland, Ans M W, van der Hout, Annemarie H, Kets, Carolien M, Aalfs, Cora M, Wijnen, Juul T, Ausems, Margreet G E M, Frost, Debra, Ellis, Steve, Fineberg, Elena, Platte, Radka, Evans, D Gareth, Jacobs, Chris, Adlard, Julian, Tischkowitz, Marc, Porteous, Mary E, Damiola, Francesca, Golmard, Lisa, Barjhoux, Laure, Longy, Michel, Belotti, Muriel, Ferrer, Sandra Fert, Mazoyer, Sylvie, Spurdle, Amanda B, Manoukian, Siranoush, Barile, Monica, Genuardi, Maurizio, Arnold, Norbert, Meindl, Alfons, Sutter, Christian, Wappenschmidt, Barbara, Domchek, Susan M, Pfeiler, Georg, Friedman, Eitan, Jensen, Uffe Birk, Robson, Mark, Shah, Sohela, Lazaro, Conxi, Mai, Phuong L, Benitez, Javier, Southey, Melissa C, Schmidt, Marjanka K, Fasching, Peter A, Peto, Julian, Humphreys, Manjeet K, Wang, Qin, Michailidou, Kyriaki, Sawyer, Elinor J, Burwinkel, Barbara, Guénel, Pascal, Bojesen, Stig E, Milne, Roger L, Brenner, Hermann, Lochmann, Magdalena, Aittomäki, Kristiina, Dörk, Thilo, Margolin, Sara

“…Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through…”
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DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers by Osorio, Ana, Milne, Roger L, Kuchenbaecker, Karoline, Vaclová, Tereza, Pita, Guillermo, Alonso, Rosario, Peterlongo, Paolo, Blanco, Ignacio, de la Hoya, Miguel, Duran, Mercedes, Díez, Orland, Ramón Y Cajal, Teresa, Konstantopoulou, Irene, Martínez-Bouzas, Cristina, Andrés Conejero, Raquel, Soucy, Penny, McGuffog, Lesley, Barrowdale, Daniel, Lee, Andrew, Arver, Brita, Rantala, Johanna, Loman, Niklas, Ehrencrona, Hans, Olopade, Olufunmilayo I, Beattie, Mary S, Domchek, Susan M, Nathanson, Katherine, Rebbeck, Timothy R, Arun, Banu K, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, John, Esther M, Whittemore, Alice S, Daly, Mary B, Southey, Melissa, Hopper, John, Terry, Mary B, Buys, Saundra S, Janavicius, Ramunas, Dorfling, Cecilia M, van Rensburg, Elizabeth J, Steele, Linda, Neuhausen, Susan L, Ding, Yuan Chun, Hansen, Thomas V O, Jønson, Lars, Ejlertsen, Bent, Gerdes, Anne-Marie, Infante, Mar, Herráez, Belén, Moreno, Leticia Thais, Weitzel, Jeffrey N, Herzog, Josef, Weeman, Kisa, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Bonanni, Bernardo, Mariette, Frederique, Volorio, Sara, Viel, Alessandra, Varesco, Liliana, Papi, Laura, Ottini, Laura, Tibiletti, Maria Grazia, Radice, Paolo, Yannoukakos, Drakoulis, Garber, Judy, Ellis, Steve, Frost, Debra, Platte, Radka, Fineberg, Elena, Evans, Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Cole, Trevor, Eccles, Diana, Cook, Jackie, Hodgson, Shirley, Brewer, Carole, Tischkowitz, Marc, Douglas, Fiona, Porteous, Mary, Side, Lucy, Walker, Lisa, Morrison, Patrick, Donaldson, Alan, Kennedy, John, Foo, Claire, Godwin, Andrew K, Schmutzler, Rita Katharina, Wappenschmidt, Barbara, Rhiem, Kerstin, Engel, Christoph, Meindl, Alfons

“…Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of…”
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Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers by Blanco, Ignacio, Kuchenbaecker, Karoline, Cuadras, Daniel, Wang, Xianshu, Barrowdale, Daniel, de Garibay, Gorka Ruiz, Librado, Pablo, Sánchez-Gracia, Alejandro, Rozas, Julio, Bonifaci, Núria, McGuffog, Lesley, Pankratz, Vernon S, Islam, Abul, Mateo, Francesca, Berenguer, Antoni, Petit, Anna, Català, Isabel, Brunet, Joan, Feliubadaló, Lidia, Tornero, Eva, Benítez, Javier, Osorio, Ana, Ramón y Cajal, Teresa, Nevanlinna, Heli, Aittomäki, Kristiina, Arun, Banu K, Toland, Amanda E, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, Greene, Mark H, Mai, Phuong L, Nussbaum, Robert L, Andrulis, Irene L, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Barkardottir, Rosa B, Jakubowska, Anna, Lubinski, Jan, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Claes, Kathleen, Van Maerken, Tom, Díez, Orland, Hansen, Thomas V, Jønson, Lars, Gerdes, Anne-Marie, Ejlertsen, Bent, de la Hoya, Miguel, Caldés, Trinidad, Dunning, Alison M, Oliver, Clare, Fineberg, Elena, Cook, Margaret, Peock, Susan, McCann, Emma, Murray, Alex, Jacobs, Chris, Pichert, Gabriella, Lalloo, Fiona, Chu, Carol, Dorkins, Huw, Paterson, Joan, Ong, Kai-Ren, Teixeira, Manuel R, Hogervorst, Frans B L, van der Hout, Annemarie H, Seynaeve, Caroline, van der Luijt, Rob B, Ligtenberg, Marjolijn J L, Devilee, Peter, Wijnen, Juul T, Rookus, Matti A, Meijers-Heijboer, Hanne E J, Blok, Marinus J, van den Ouweland, Ans M W, Aalfs, Cora M, Rodriguez, Gustavo C, Phillips, Kelly-Anne A, Piedmonte, Marion, Nerenstone, Stacy R, Bae-Jump, Victoria L, O'Malley, David M, Ratner, Elena S, Schmutzler, Rita K, Wappenschmidt, Barbara, Rhiem, Kerstin, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg J, Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda

“…While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may…”
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Lymphocyte Telomere Length Is Long in BRCA1 and BRCA2 Mutation Carriers Regardless of Cancer-Affected Status by POOLEY, Karen A, MCGUFFOG, Lesley, BREWER, Carole, COLE, Trevor, COOK, Jackie, DAVIDSON, Rosemarie, DONALDSON, Alan, DORKINS, Huw, DOUGLAS, Fiona, EASON, Jacqueline, HOUGHTON, Catherine, KENNEDY, M. John, BARROWDALE, Daniel, MCCANN, Emma, MIEDZYBRODZKA, Zosia, MURRAY, Alex, PORTEOUS, Mary E, ROGERS, Mark T, SIDE, Lucy E, TISCHKOWITZ, Marc, WALKER, Lisa, HODGSON, Shirley, ECCLES, Diana M, FROST, Debra, MORRISON, Patrick J, EVANS, D. Gareth, EELES, Rosalind A, ANTONIOU, Antonis C, EASTON, Douglas F, DUNNING, Alison M, ELLIS, Steve D, FINEBERG, Elena, PLATTE, Radka, IZATT, Louise, ADLARD, Julian, BARDWELL, Julian

“…Telomere length has been linked to risk of common diseases, including cancer, and has previously been proposed as a biomarker for cancer risk. Germline BRCA1…”
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