Search Results - "FINE, Bernard M"

Molecular biomarker analyses using circulating tumor cells by Punnoose, Elizabeth A, Atwal, Siminder K, Spoerke, Jill M, Savage, Heidi, Pandita, Ajay, Yeh, Ru-Fang, Pirzkall, Andrea, Fine, Bernard M, Amler, Lukas C, Chen, Daniel S, Lackner, Mark R

“…Evaluation of cancer biomarkers from blood could significantly enable biomarker assessment by providing a relatively non-invasive source of representative…”
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Clinical pharmacology of vc-MMAE antibody-drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies by Li, Chunze, Zhang, Cindy, Li, Zao, Samineni, Divya, Lu, Dan, Wang, Bei, Chen, Shang-Chiung, Zhang, Rong, Agarwal, Priya, Fine, Bernard M, Girish, Sandhya

“…vc-MMAE antibody-drug conjugates (ADCs) consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a…”
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A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients by HONGYUE DAI, VAN'T VEER, Laura, STOUGHTON, Roland, FRIEND, Stephen, LAMB, John, HE, Yudong D, MAO MAO, FINE, Bernard M, BERNARDS, Rene, VAN DE VIJVER, Marc, DEUTSCH, Paul, SACHS, Alan

“…Breast cancer comprises a group of distinct subtypes that despite having similar histologic appearances, have very different metastatic potentials. Being able…”
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Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody–Drug Conjugates by Kågedal, Matts, Samineni, Divya, Gillespie, William R., Lu, Dan, Fine, Bernard M., Girish, Sandhya, Li, Chunze, Jin, Jin Y.

“…Peripheral neuropathy (PN) is a common long‐term debilitating toxicity of antimicrotubule agents. PN was the most frequent adverse event resulting in dose…”
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A genome-wide view of the in vitro response to L-asparaginase in acute lymphoblastic leukemia by FINE, Bernard M, KASPERS, Gertjan J. L, MINH HO, LOONEN, Anne H, BOXER, Linda M

“…To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used cDNA microarrays to obtain a genome-wide view of gene expression…”
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Evaluation of Circulating Tumor Cells and Circulating Tumor DNA in Non―Small Cell Lung Cancer: Association with Clinical Endpoints in a Phase II Clinical Trial of Pertuzumab and Erlotinib by PUNNOOSE, Elizabeth A, ATWAL, Siminder, LACKNER, Mark R, WEIQUN LIU, RAJA, Rajiv, FINE, Bernard M, HUGHES, Brett G. M, HICKS, Rodney J, HAMPTON, Garret M, AMLER, Lukas C, PIRZKALL, Andrea

“…Elevated levels or increases in circulating tumor cells (CTC) portend poor prognosis in patients with epithelial cancers. Less is known about CTCs as surrogate…”
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Phase I Study of DSTP3086S, an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1, in Metastatic Castration-Resistant Prostate Cancer by Danila, Daniel C, Szmulewitz, Russell Z, Vaishampayan, Ulka, Higano, Celestia S, Baron, Ari D, Gilbert, Houston N, Brunstein, Flavia, Milojic-Blair, Marija, Wang, Bei, Kabbarah, Omar, Mamounas, Michael, Fine, Bernard M, Maslyar, Daniel J, Ungewickell, Alexander, Scher, Howard I

“…Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is highly expressed in prostate cancers. DSTP3086S is a humanized immunoglobulin G1 anti-STEAP1…”
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Whole-body CD8+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial by Kist de Ruijter, Laura, van de Donk, Pim P., Hooiveld-Noeken, Jahlisa S., Giesen, Danique, Elias, Sjoerd G., Lub-de Hooge, Marjolijn N., Oosting, Sjoukje F., Jalving, Mathilde, Timens, Wim, Brouwers, Adrienne H., Kwee, Thomas C., Gietema, Jourik A., Fehrmann, Rudolf S. N., Fine, Bernard M., Sanabria Bohórquez, Sandra M., Yadav, Mahesh, Koeppen, Hartmut, Jing, Jing, Guelman, Sebastian, Lin, Mark T., Mamounas, Michael J., Eastham, Jeffrey Ryan, Kimes, Patrick K., Williams, Simon P., Ungewickell, Alexander, de Groot, Derk J. A., de Vries, Elisabeth G. E.

“…Immune checkpoint inhibitors (ICIs), by reinvigorating CD8 + T cell mediated immunity, have revolutionized cancer therapy. Yet, the systemic CD8 + T cell…”
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ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody-Drug Conjugate Treatment by Lamberts, Laetitia E, Menke-van der Houven van Oordt, Catharina W, ter Weele, Eva J, Bensch, Frederike, Smeenk, Michiel M, Voortman, Johannes, Hoekstra, Otto S, Williams, Simon P, Fine, Bernard M, Maslyar, Daniel, de Jong, Johan R, Gietema, Jourik A, Schröder, Carolien P, Bongaerts, Alphons H H, Lub-de Hooge, Marjolijn N, Verheul, Henk M W, Sanabria Bohorquez, Sandra M, Glaudemans, Andor W J M, de Vries, Elisabeth G E

“…Mesothelin (MSLN) is frequently overexpressed in pancreatic and ovarian cancers, making it a potential drug target. We performed an (89)Zr-PET imaging study…”
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Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic by Stagg, Nicola J., Shen, Ben-Quan, Brunstein, Flavia, Li, Chunze, Kamath, Amrita V., Zhong, Fiona, Schutten, Melissa, Fine, Bernard M.

“…Antibody drug conjugates (ADC) consist of potent cytotoxic drugs conjugated to antibodies via chemical linkers, which enables specific targeting of tumor cells…”
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Pharmacokinetics and Biodistribution of a [89Zr]Zr-DFO-MSTP2109A Anti-STEAP1 Antibody in Metastatic Castration-Resistant Prostate Cancer Patients by O’Donoghue, Joseph A, Danila, Daniel C, Pandit-Taskar, Neeta, Beylergil, Volkan, Cheal, Sarah M, Fleming, Stephen E, Fox, Josef J, Ruan, Shutian, Zanzonico, Pat B, Ragupathi, Govind, Lyashchenko, Serge K, Williams, Simon P, Scher, Howard I, Fine, Bernard M, Humm, John L, Larson, Steven M, Morris, Michael J, Carrasquillo, Jorge A

“…A six-transmembrane epithelial antigen of prostate-1 (STEAP1) is a newly identified target in prostate cancer. The use of radio-labeled STEAP1-targeting…”
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Pertuzumab and Erlotinib in Patients With Relapsed Non‐Small Cell Lung Cancer: A Phase II Study Using 18F‐Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging by Hughes, Brett, Mileshkin, Linda, Townley, Peter, Gitlitz, Barbara, Eaton, Keith, Mitchell, Paul, Hicks, Rodney, Wood, Katie, Amler, Lucas, Fine, Bernard M., Loecke, David, Pirzkall, Andrea

“…Background. Combination blockade of human epidermal growth factor receptor (HER) family signaling may confer enhanced antitumor activity than single‐agent…”
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Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using 89Zr-DFO-MSTP2109A Anti-STEAP1 Antibody by Carrasquillo, Jorge A, Fine, Bernard M, Pandit-Taskar, Neeta, Larson, Steven M, Fleming, Stephen E, Fox, Josef J, Cheal, Sarah M, O'Donoghue, Joseph A, Ruan, Shutian, Ragupathi, Govind, Lyashchenko, Serge K, Humm, John L, Scher, Howard I, Gönen, Mithat, Williams, Simon P, Danila, Daniel C, Morris, Michael J

“…Six-transmembrane epithelial antigen of prostate-1 (STEAP1) is a relatively newly identified target in prostate cancer. We evaluated the ability of PET/CT with…”
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Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using 89 Zr-DFO-MSTP2109A Anti-STEAP1 Antibody by Carrasquillo, Jorge A, Fine, Bernard M, Pandit-Taskar, Neeta, Larson, Steven M, Fleming, Stephen E, Fox, Josef J, Cheal, Sarah M, O'Donoghue, Joseph A, Ruan, Shutian, Ragupathi, Govind, Lyashchenko, Serge K, Humm, John L, Scher, Howard I, Gönen, Mithat, Williams, Simon P, Danila, Daniel C, Morris, Michael J

“…Six-transmembrane epithelial antigen of prostate-1 (STEAP1) is a relatively newly identified target in prostate cancer. We evaluated the ability of PET/CT with…”
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89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer by Bensch, Frederike, van der Veen, Elly L., Lub-de Hooge, Marjolijn N., Jorritsma-Smit, Annelies, Boellaard, Ronald, Kok, Iris C., Oosting, Sjoukje F., Schröder, Carolina P., Hiltermann, T. Jeroen N., van der Wekken, Anthonie J., Groen, Harry J. M., Kwee, Thomas C., Elias, Sjoerd G., Gietema, Jourik A., Bohorquez, Sandra Sanabria, de Crespigny, Alex, Williams, Simon-Peter, Mancao, Christoph, Brouwers, Adrienne H., Fine, Bernard M., de Vries, Elisabeth G. E.

“…Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) blockade is effective in a subset of patients with several tumor types, but predicting patient benefit…”
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Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates by Kågedal, Matts, Gibiansky, Leonid, Xu, Jian, Wang, Xin, Samineni, Divya, Chen, Shang-Chiung, Lu, Dan, Agarwal, Priya, Wang, Bei, Saad, Ola, Koppada, Neelima, Fine, Bernard M., Jin, Jin Y., Girish, Sandhya, Li, Chunze

“…Antibody–drug conjugates (ADCs) developed using the valine-citrulline-MMAE (vc-MMAE) platform, consist of a monoclonal antibody (mAb) covalently bound with a…”
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Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia by Cario, Gunnar, Stanulla, Martin, Fine, Bernard M., Teuffel, Oliver, Neuhoff, Nils v., Schrauder, André, Flohr, Thomas, Schäfer, Beat W., Bartram, Claus R., Welte, Karl, Schlegelberger, Brigitte, Schrappe, Martin

“…Treatment resistance, as indicated by the presence of high levels of minimal residual disease (MRD) after induction therapy and induction consolidation, is…”
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Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer by Binns, David S., Pirzkall, Andrea, Yu, Wei, Callahan, Jason, Mileshkin, Linda, Conti, Peter, Scott, Andrew M., Macfarlane, David, Fine, Bernard M., Hicks, Rodney J.

“…Purpose The Response Evaluation Criteria in Solid Tumors (RECIST) are widely used but have recognized limitations. Molecular imaging assessments, including…”
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Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia by Fine, Bernard M., Stanulla, Martin, Schrappe, Martin, Ho, Minh, Viehmann, Susanne, Harbott, Jochen, Boxer, Linda M.

“…We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected…”
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89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer by Bensch, Frederike, van der Veen, Elly L., Lub-de Hooge, Marjolijn N., Jorritsma-Smit, Annelies, Boellaard, Ronald, Kok, Iris C., Oosting, Sjoukje F., Schröder, Carolina P., Hiltermann, T. Jeroen N., van der Wekken, Anthonie J., Groen, Harry J. M., Kwee, Thomas C., Elias, Sjoerd G., Gietema, Jourik A., Bohorquez, Sandra Sanabria, de Crespigny, Alex, Williams, Simon-Peter, Mancao, Christoph, Brouwers, Adrienne H., Fine, Bernard M., de Vries, Elisabeth G. E.

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