Search Results - "FILVAROFF, Ellen"

A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms by Wolin, Edward, Mita, Alain, Mahipal, Amit, Meyer, Tim, Bendell, Johanna, Nemunaitis, John, Munster, Pam N, Paz-Ares, Luis, Filvaroff, Ellen H, Li, Shaoyi, Hege, Kristen, de Haan, Hans, Mita, Monica

“…Second-generation mammalian target of rapamycin (mTOR) inhibitors such as CC-223 may have theoretical advantages over first-generation drugs by inhibiting TOR…”
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Clinical activity of CC‐90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies by Hollebecque, Antoine, Salvagni, Stefania, Plummer, Ruth, Niccoli, Patricia, Capdevila, Jaume, Curigliano, Giuseppe, Moreno, Victor, Braud, Filippo, Villambrosia, Sonia Gonzalez, Martin‐Romano, Patricia, Baudin, Eric, Arias, Marina, Alvaro, Juan, Parra‐Palau, Josep L., Sánchez‐Pérez, Tania, Aronchik, Ida, Filvaroff, Ellen H., Lamba, Manisha, Nikolova, Zariana, Bono, Johann S.

“…Background CC‐90011 is an oral, potent, selective, reversible inhibitor of lysine‐specific demethylase 1 (LSD1) that was well tolerated, with encouraging…”
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Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma by Hollebecque, Antoine, Salvagni, Stefania, Plummer, Ruth, Isambert, Nicolas, Niccoli, Patricia, Capdevila, Jaume, Curigliano, Giuseppe, Moreno, Victor, Martin-Romano, Patricia, Baudin, Eric, Arias, Marina, Mora, Sheila, de Alvaro, Juan, Di Martino, Jorge, Parra-Palau, Josep L, Sánchez-Pérez, Tania, Aronchik, Ida, Filvaroff, Ellen H, Lamba, Manisha, Nikolova, Zariana, de Bono, Johann S

“…Lysine-specific demethylase 1 (LSD1) is implicated in multiple tumor types, and its expression in cancer stem cells is associated with chemoresistance…”
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Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance by Aronchik, Ida, Dai, Yumin, Labenski, Matt, Barnes, Carmen, Jones, Terri, Qiao, Lixin, Beebe, Lisa, Malek, Mehnaz, Elis, Winfried, Shi, Tao, Mavrommatis, Konstantinos, Bray, Gordon L, Filvaroff, Ellen H

“…As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven by activation of the MAPK pathway. Utility of targeting the…”
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Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia by Thijssen, Rachel, ter Burg, Johanna, Garrick, Brett, van Bochove, Gregor G.W., Brown, Jennifer R., Fernandes, Stacey M., Rodríguez, María Solé, Michot, Jean-Marie, Hallek, Michael, Eichhorst, Barbara, Reinhardt, Hans Christian, Bendell, Johanna, Derks, Ingrid A.M., van Kampen, Roel J.W., Hege, Kristen, Kersten, Marie José, Trowe, Torsten, Filvaroff, Ellen H., Eldering, Eric, Kater, Arnon P.

“…Inhibition of B-cell receptor (BCR) signaling pathways in chronic lymphocytic leukemia (CLL) provides significant clinical benefit to patients, mainly by…”
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Shallow shotgun sequencing reduces technical variation in microbiome analysis by La Reau, Alex J., Strom, Noah B., Filvaroff, Ellen, Mavrommatis, Konstantinos, Ward, Tonya L., Knights, Dan

“…The microbiome is known to play a role in many human diseases, but identifying key microbes and their functions generally requires large studies due to the…”
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First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy by Munster, Pamela, Mita, Monica, Mahipal, Amit, Nemunaitis, John, Massard, Christophe, Mikkelsen, Tom, Cruz, Cristina, Paz-Ares, Luis, Hidalgo, Manuel, Rathkopf, Dana, Blumenschein, Jr, George, Smith, David C, Eichhorst, Barbara, Cloughesy, Tim, Filvaroff, Ellen H, Li, Shaoyi, Raymon, Heather, de Haan, Hans, Hege, Kristen, Bendell, Johanna C

“…This first-in-human Phase I study investigated the safety, pharmacokinetics (PK), pharmacodynamic profile, and preliminary efficacy of CC-115, a dual inhibitor…”
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Author Correction: Shallow shotgun sequencing reduces technical variation in microbiome analysis by La Reau, Alex J., Strom, Noah B., Filvaroff, Ellen, Mavrommatis, Konstantinos, Ward, Tonya L., Knights, Dan

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Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis by Caunt, Maresa, Mak, Judy, Liang, Wei-Ching, Stawicki, Scott, Pan, Qi, Tong, Raymond K., Kowalski, Joe, Ho, Calvin, Reslan, Hani Bou, Ross, Jed, Berry, Leanne, Kasman, Ian, Zlot, Constance, Cheng, Zhiyong, Le Couter, Jennifer, Filvaroff, Ellen H., Plowman, Greg, Peale, Franklin, French, Dorothy, Carano, Richard, Koch, Alexander W., Wu, Yan, Watts, Ryan J., Tessier-Lavigne, Marc, Bagri, Anil

“…Metastasis, which commonly uses lymphatics, accounts for much of the mortality associated with cancer. The vascular endothelial growth factor (VEGF)-C…”
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BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas by Moreno, Victor, Vieito, Maria, Sepulveda, Juan Manuel, Galvao, Vladimir, Hernández-Guerrero, Tatiana, Doger, Bernard, Saavedra, Omar, Carlo-Stella, Carmelo, Michot, Jean-Marie, Italiano, Antoine, Magagnoli, Massimo, Carpio, Cecilia, Pinto, Antonio, Sarmiento, Rafael, Amoroso, Barbara, Aronchik, Ida, Filvaroff, Ellen, Hanna, Bishoy, Wei, Xin, Nikolova, Zariana, Braña, Irene

“…Bromodomain and extraterminal proteins (BET) play key roles in regulation of gene expression, and may play a role in cancer-cell proliferation, survival, and…”
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Angiogenesis and bone repair by Carano, Richard A.D, Filvaroff, Ellen H

“…The intimate connection, both physical and biochemical, between blood vessels and bone cells has long been recognized. Genetic, biochemical, and…”
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Vascular Endothelial Growth Factor Stimulates Bone Repair by Promoting Angiogenesis and Bone Turnover by Street, John, Bao, Min, deGuzman, Leo, Bunting, Stuart, Peale, Franklin V., Ferrara, Napoleone, Steinmetz, Hope, Hoeffel, John, Cleland, Jeffrey L., Daugherty, Ann, van Bruggen, Nicholas, Redmond, H. Paul, Richard A. D. Carano, Filvaroff, Ellen H.

“…Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is…”
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Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies by Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F, Raymon, Heather K, McCue, Peter A, Shafi, Ayesha A, Leiby, Benjamin E, de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati N, Schiewer, Matthew J, Brand, Lucas J, Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S, Gomella, Leonard G, Lallas, Costas D, Trabulsi, Edouard J, Feng, Felix Y, Filvaroff, Ellen H, Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E

“…DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in…”
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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 by Wu, Ai-Luen, Kolumam, Ganesh, Stawicki, Scott, Chen, Yongmei, Li, Jun, Zavala-Solorio, Jose, Phamluong, Khanhky, Feng, Bo, Li, Li, Marsters, Scot, Kates, Lance, van Bruggen, Nicholas, Leabman, Maya, Wong, Anne, West, David, Stern, Howard, Luis, Elizabeth, Kim, Hok Seon, Yansura, Daniel, Peterson, Andrew S, Filvaroff, Ellen, Wu, Yan, Sonoda, Junichiro

“…Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed;…”
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SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma by Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.

“…Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein…”
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DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway by Kothari, Vishal, Goodwin, Jonathan F, Zhao, Shuang G, Drake, Justin M, Yin, Yi, Chang, S Laura, Evans, Joseph R, Wilder-Romans, Kari, Gabbara, Kristina, Dylgjeri, Emanuela, Chou, Jonathan, Sun, Grace, Tomlins, Scott A, Mehra, Rohit, Hege, Kristen, Filvaroff, Ellen H, Schaeffer, Edward M, Karnes, R Jeffrey, Quigley, David A, Rathkopf, Dana E, He, Housheng H, Speers, Corey, Spratt, Daniel E, Gilbert, Luke A, Ashworth, Alan, Chinnaiyan, Arul M, Raj, Ganesh V, Knudsen, Karen E, Feng, Felix Y

“…Protein kinases are known to play a prominent role in oncogenic progression across multiple cancer subtypes, yet their role in prostate cancer progression…”
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TGF-β Regulates the Mechanical Properties and Composition of Bone Matrix by Guive Balooch, Mehdi Balooch, Nalla, Ravi K., Schilling, Stephen, Filvaroff, Ellen H., Grayson W. Marshall, Sally J. Marshall, Robert O. Ritchie, Derynck, Rik, Tamara Alliston

“…The characteristic toughness and strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produced by osteoblasts. The…”
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Angiogenesis Is Required for Successful Bone Induction During Distraction Osteogenesis by Fang, Tony D, Salim, Ali, Xia, Wei, Nacamuli, Randall P, Guccione, Samira, Song, HanJoon M, Carano, Richard A, Filvaroff, Ellen H, Bednarski, Mark D, Giaccia, Amato J, Longaker, Michael T

“…The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the mechanical environment,…”
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TWEAK Attenuates the Transition from Innate to Adaptive Immunity by Maecker, Heather, Varfolomeev, Eugene, Kischkel, Frank, Lawrence, David, LeBlanc, Heidi, Lee, Wyne, Hurst, Stephen, Danilenko, Dimitry, Li, Jun, Filvaroff, Ellen, Yang, Becky, Daniel, Dylan, Ashkenazi, Avi

“…Innate immunity is the first line of defense against infection, protecting the host during the development of adaptive immunity and critically affecting the…”
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IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding by Hymowitz, Sarah G., Filvaroff, Ellen H., Yin, JianPing, Lee, James, Cai, Liping, Risser, Philip, Maruoka, Miko, Mao, Weiguang, Foster, Jessica, Kelley, Robert F., Pan, Guohua, Gurney, Austin L., de Vos, Abraham M., Starovasnik, Melissa A.

“…The proinflammatory cytokine interleukin 17 (IL‐17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a…”
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