Search Results - "FILOTEO, A. G"

Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility by Strehler, E E, Filoteo, A G, Penniston, J T, Caride, A J

“…Plasma-membrane calcium pumps [PMCAs (plasma-membrane Ca(2+)-ATPases)] expel Ca(2+) from eukaryotic cells to maintain overall Ca(2+) homoeostasis and to…”
Get more information

Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger by Li, Z, Nicoll, D A, Collins, A, Hilgemann, D W, Filoteo, A G, Penniston, J T, Weiss, J N, Tomich, J M, Philipson, K D

“…The deduced amino acid sequence of the cardiac sarcolemmal Na(+)-Ca2+ exchanger has a region which could represent a calmodulin binding site. As calmodulin…”
Get full text

The Ca2+ affinity of the plasma membrane Ca2+ pump is controlled by alternative splicing by ENYEDI, A, VERMA, A. K, HEIM, R, ADAMO, H. P, FILOTEO, A. G, STREHLER, E. E, PENNISTON, J. T

“…The plasma membrane Ca2+ pump is a calmodulin-regulated P-type ATPase that is an essential element in controlling intracellular Ca2+ concentration. Studies on…”
Get full text

A highly active 120-kDa truncated mutant of the plasma membrane Ca2+ pump by Enyedi, A., Verma, A.K., Filoteo, A.G., Penniston, J.T.

“…A truncated mutant (hPMCA4b(ct120)) of the plasma membrane Ca2+ pump was expressed in COS-1 cells. The full-length pump (hPMCA4b) consisted of 1205 residues,…”
Get full text

The lipid-binding peptide from the plasma membrane Ca2+ pump binds calmodulin, and the primary calmodulin-binding domain interacts with lipid by FILOTEO, A. G, ENYEDI, A, PENNISTON, J. T

“…Peptide G25 (KKAVKVPKKEKSVLQGKLTRLAVQI) representing the putative lipid-binding region (G region) of the erythrocyte Ca2+ pump was synthesized. This peptide…”
Get full text

Regulatory region of plasma membrane Ca2+ pump. 28 residues suffice to bind calmodulin but more are needed for full auto-inhibition of the activity by VERMA, A. K, ENYEDI, A, FILOTEO, A. G, PENNISTON, J. T

“…The Ca(2+)-pumping activity of constructs containing various portions of the putative 28-residue calmodulin-binding domain (C domain) of hPMCA4b were compared…”
Get full text

Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane by STREHLER, E. E, JAMES, P, FISCHER, R, HEIM, R, VORHERR, T, FILOTEO, A. G, PENNISTON, J. T, CARAFOLI, E

“…The sequence of more than 1,000 amino acid residues, derived from two different isoforms, has been determined from peptides generated from purified human…”
Get full text

Modification of Human Hearing Loss by Plasma-Membrane Calcium Pump PMCA2 by Schultz, Julie M, Yang, Yandan, Caride, Ariel J, Filoteo, Adelaida G, Penheiter, Alan R, Lagziel, Ayala, Morell, Robert J, Mohiddin, Saidi A, Fananapazir, Lameh, Madeo, Anne C, Penniston, John T, Griffith, Andrew J

“…This study implicates a variant of a gene encoding PMCA2, a plasma-membrane calcium pump, in the degree of severity of hearing loss caused by the mutation of…”
Get full text

Calmodulin-binding domains from isozymes of the plasma membrane Ca2+ pump have different regulatory properties by ENYEDI, A, FILOTEO, A. G, GARDOS, G, PENNISTON, J. T

“…Peptides C28R2 and C28R1A, representing the two main alternative classes of calmodulin-binding domains from the plasma membrane Ca2+ pump, were tested for…”
Get full text

Plasma Membrane Ca2+-ATPase Isoform 2a Is the PMCA of Hair Bundles by Dumont, Rachel A, Lins, Ulysses, Filoteo, Adelaida G, Penniston, John T, Kachar, Bechara, Gillespie, Peter G

“…Mechanoelectrical transduction channels of hair cells allow for the entry of appreciable amounts of Ca(2+), which regulates adaptation and triggers the…”
Get full text

Expression and cellular distribution pattern of plasma membrane calcium pump isoforms in rat pancreatic islets by García, M E, Del Zotto, H, Caride, A J, Filoteo, A G, Penniston, J T, Rossi, J P F C, Gagliardino, J J

“…This work is aimed at identifying the presence and cellular distribution pattern of plasma membrane calcium pump (PMCA) isoforms in normal rat pancreatic…”
Get full text

The ATP-binding site of the erythrocyte membrane Ca2+ pump. Amino acid sequence of the fluorescein isothiocyanate-reactive region by Filoteo, A G, Gorski, J P, Penniston, J T

“…The erythrocyte plasma membrane Ca2+-pumping ATPase is known to form an acyl-phosphate catalytic intermediate, but there is otherwise little structural…”
Get full text

The plasma membrane calcium pump displays memory of past calcium spikes. Differences between isoforms 2b and 4b by Caride, A J, Penheiter, A R, Filoteo, A G, Bajzer, Z, Enyedi, A, Penniston, J T

“…To understand how the plasma membrane Ca(2+) pump (PMCA) behaves under changing Ca(2+) concentrations, it is necessary to obtain information about the Ca(2+)…”
Get full text

Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells by Caride, A J, Filoteo, A G, Penheiter, A R, Pászty, K, Enyedi, A, Penniston, J T

“…There are four genes encoding isoforms of the plasma membrane Ca(2+) pump (PMCA). PMCA variability is increased by the presence of two splicing sites…”
Get full text

Plasma membrane Ca2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies by Filoteo, A G, Elwess, N L, Enyedi, A, Caride, A, Aung, H H, Penniston, J T

“…The expression at the protein level of plasma membrane calcium pump (PMCA) isoforms in rat brain was detected by new antibodies that distinguished the four…”
Get full text

A Model for the Activation of Plasma Membrane Calcium Pump Isoform 4b by Calmodulin by Penheiter, Alan R, Bajzer, Željko, Filoteo, Adelaida G, Thorogate, Richard, Török, Katalin, Caride, Ariel J

“…Overexpression of the plasma membrane calcium pump (PMCA) isoform 4b by means of the baculovirus system enabled us, for the first time, to study the kinetics…”
Get full text

Kinetic Analysis of the Calmodulin-Binding Region of the Plasma Membrane Calcium Pump Isoform 4b by Penheiter, Alan R., Filoteo, Adelaida G., Penniston, John T., Caride, Ariel J.

“…The sequence L1086RRGQILWFRGLNRIQTQIKVVKAFHSS1113 (peptide C28) is responsible for calmodulin binding to PMCA4b. In this work, peptides following the above…”
Get full text

Plasma Membrane Ca2+ Pump Isoforms 2a and 2b Are Unusually Responsive to Calmodulin and Ca2 by Elwess, Nancy L., Filoteo, Adelaida G., Enyedi, Agnes, Penniston, John T.

“…The full-length a and b variants of the rat plasma membrane calcium pump, isoform 2 (rPMCA2a and rPMCA2b), were constructed and expressed in COS-7 cells. To…”
Get full text

Intramolecular Interactions of the Regulatory Region with the Catalytic Core in the Plasma Membrane Calcium Pump by Padányi, Rita, Pászty, Katalin, Penheiter, Alan R., Filoteo, Adelaida G., Penniston, John T., Enyedi, Ágnes

“…The access of three proteases to their sites of cleavage was used as a measure of regulatory interactions in the plasma membrane Ca2+ pump isoform 4b (PMCA4b)…”
Get full text

Detection of isoform 4 of the plasma membrane calcium pump in human tissues by using isoform-specific monoclonal antibodies by Caride, A J, Filoteo, A G, Enyedi, A, Verma, A K, Penniston, J T

“…The epitope location and specificity of monoclonal antibodies JA9, 5F10 and JA3, raised against the human plasma membrane Ca2+ pump (hPMCA), were analysed by…”
Get full text