Search Results - "FILLIT, Howard"

Aducanumab and the FDA — where are we now? by Fillit, Howard, Green, Allan

“…The amyloid antibody aducanumab is currently undergoing review by the FDA. The treatment would be the first disease-modifying drug to be approved for Alzheimer…”
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Translating the biology of aging into novel therapeutics for Alzheimer disease by Hara, Yuko, McKeehan, Nicholas, Fillit, Howard M

“…Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer disease (AD), a progressive neurodegenerative disease with…”
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Dementia Diagnosis Disparities by Race and Ethnicity by Lin, Pei-Jung, Daly, Allan T., Olchanski, Natalia, Cohen, Joshua T., Neumann, Peter J., Faul, Jessica D., Fillit, Howard M., Freund, Karen M.

“…Background: Dementia is often underdiagnosed and this problem is more common among some ethnoracial groups. Objective: The objective of this study was to…”
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Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis by Lin, Pei-Jung, Zhong, Yue, Fillit, Howard M., Chen, Er, Neumann, Peter J.

“…Objectives To characterize Medicare expenditure and usage trends in individuals with a coded diagnosis of Alzheimer's disease and related dementia (ADRD) or…”
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A Brain Capital Grand Strategy: toward economic reimagination by Smith, Erin, Ali, Diab, Wilkerson, Bill, Dawson, Walter D., Sobowale, Kunmi, Reynolds, Charles, Berk, Michael, Lavretsky, Helen, Jeste, Dilip, Ng, Chee H., Soares, Jair C., Aragam, Gowri, Wainer, Zoe, Manji, Husseini K., Licinio, Julio, Lo, Andrew W., Storch, Eric, Fu, Ernestine, Leboyer, Marion, Tarnanas, Ioannis, Ibanez, Agustin, Manes, Facundo, Caddick, Sarah, Fillit, Howard, Abbott, Ryan, Robertson, Ian H., Chapman, Sandra B., Au, Rhoda, Altimus, Cara M., Hynes, William, Brannelly, Patrick, Cummings, Jeffrey, Eyre, Harris A.

“…‘I have not found among my possessions anything which I hold more dear than, or value so much as, my knowledge of the actions of great people, acquired by long…”
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Developing novel blood-based biomarkers for Alzheimer's disease by Snyder, Heather M, Carrillo, Maria C, Grodstein, Francine, Henriksen, Kim, Jeromin, Andreas, Lovestone, Simon, Mielke, Michelle M, O'Bryant, Sid, Sarasa, Manual, Sjøgren, Magnus, Soares, Holly, Teeling, Jessica, Trushina, Eugenia, Ward, Malcolm, West, Tim, Bain, Lisa J, Shineman, Diana W, Weiner, Michael, Fillit, Howard M

“…Abstract Alzheimer's disease is the public health crisis of the 21st century. There is a clear need for a widely available, inexpensive and reliable method to…”
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The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease by Colom-Cadena, Martí, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T, Fillit, Howard, Harrison, John E, Schneider, Lon S, Scheltens, Phillip, de Haan, Willem, Grundman, Michael, van Dyck, Christopher H, Izzo, Nicholas J, Catalano, Susan M

“…Synapse damage and loss are fundamental to the pathophysiology of Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is…”
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A call for transparent reporting to optimize the predictive value of preclinical research by Landis, Story C., Amara, Susan G., Asadullah, Khusru, Austin, Chris P., Blumenstein, Robi, Bradley, Eileen W., Crystal, Ronald G., Darnell, Robert B., Ferrante, Robert J., Fillit, Howard, Finkelstein, Robert, Fisher, Marc, Gendelman, Howard E., Golub, Robert M., Goudreau, John L., Gross, Robert A., Gubitz, Amelie K., Hesterlee, Sharon E., Howells, David W., Huguenard, John, Kelner, Katrina, Koroshetz, Walter, Krainc, Dimitri, Lazic, Stanley E., Levine, Michael S., Macleod, Malcolm R., McCall, John M., Moxley III, Richard T., Narasimhan, Kalyani, Noble, Linda J., Perrin, Steve, Porter, John D., Steward, Oswald, Unger, Ellis, Utz, Ursula, Silberberg, Shai D.

“…Deficiencies in methods reporting in animal experimentation lead to difficulties in reproducing experiments; the authors propose a set of reporting standards…”
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Potentially avoidable hospitalizations among Medicare beneficiaries with Alzheimer’s disease and related disorders by Lin, Pei-Jung, Fillit, Howard M, Cohen, Joshua T, Neumann, Peter J

“…Abstract Background Individuals with Alzheimer's disease and related disorders (ADRD) have more frequent hospitalizations than individuals without ADRD, and…”
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Racial and Ethnic Differences in Knowledge About One's Dementia Status by Lin, Pei‐Jung, Emerson, Joanna, Faul, Jessica D., Cohen, Joshua T., Neumann, Peter J., Fillit, Howard M., Daly, Allan T., Margaretos, Nikoletta, Freund, Karen M.

“…OBJECTIVES To examine racial and ethnic differences in knowledge about oneʼs dementia status. DESIGN Prospective cohort study. SETTING The 2000 to 2014 Health…”
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The Frailty Identity Crisis by Fillit, Howard, Butler, Robert N.

“…Frailty is a common and central problem of old age. Recent research has defined frailty as an accumulation of deficits or as a distinct clinical syndrome…”
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Racial and ethnic differences in disease course Medicare expenditures for beneficiaries with dementia by Olchanski, Natalia, Zhu, Yingying, Liang, Lichen, Cohen, Joshua T., Faul, Jessica D., Fillit, Howard M., Freund, Karen M., Lin, Pei‐Jung

“…Background Research on racial and ethnic disparities in costs of care during the course of dementia is sparse. We analyzed Medicare expenditures for…”
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Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis by Aigbogun, Myrlene Sanon, Stellhorn, Robert, Hartry, Ann, Baker, Ross A, Fillit, Howard

“…Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and…”
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Hospitalizations for ambulatory care sensitive conditions and unplanned readmissions among Medicare beneficiaries with Alzheimer's disease by Lin, Pei-Jung, Zhong, Yue, Fillit, Howard M., Cohen, Joshua T., Neumann, Peter J.

“…Medicare beneficiaries with Alzheimer's disease and related dementias (ADRDs) may have more potentially avoidable hospitalizations and readmissions than people…”
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Value-Generating Exploratory Trials in Neurodegenerative Dementias by Friedman, Lauren G., McKeehan, Nicholas, Hara, Yuko, Cummings, Jeffrey L., Matthews, Dawn C., Zhu, Jian, Mohs, Richard C., Wang, Deli, Hendrix, Suzanne B., Quintana, Melanie, Schneider, Lon S., Grundman, Michael, Dickson, Samuel P., Feldman, Howard H., Jaeger, Judith, Finger, Elizabeth C., Ryan, J. Michael, Niehoff, Debra, Dickinson, Susan L-J., Markowitz, Jessica T., Owen, Meriel, Travaglia, Alessio, Fillit, Howard M.

“…Drug development for Alzheimer disease and other neurodegenerative dementias, including frontotemporal dementia, has experienced a long history of phase 2 and…”
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Alzheimer's disease medication use and adherence patterns by race and ethnicity by Olchanski, Natalia, Daly, Allan T., Zhu, Yingying, Breslau, Rachel, Cohen, Joshua T., Neumann, Peter J., Faul, Jessica D., Fillit, Howard M., Freund, Karen M., Lin, Pei‐Jung

“…Background We examined racial and ethnic differences in medication use for a representative US population of patients with Alzheimer's disease and related…”
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Life-Sustaining Treatments Among Medicare Beneficiaries with and without Dementia at the End of Life by Zhu, Yingying, Olchanski, Natalia, Cohen, Joshua T, Freund, Karen M, Faul, Jessica D, Fillit, Howard M, Neumann, Peter J, Lin, Pei-Jung

“…Older adults with dementia including Alzheimer's disease may have difficulty communicating their treatment preferences and thus may receive intensive…”
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Improving dementia care: The role of screening and detection of cognitive impairment by Borson, Soo, Frank, Lori, Bayley, Peter J, Boustani, Malaz, Dean, Marge, Lin, Pei-Jung, McCarten, J. Riley, Morris, John C, Salmon, David P, Schmitt, Frederick A, Stefanacci, Richard G, Mendiondo, Marta S, Peschin, Susan, Hall, Eric J, Fillit, Howard, Ashford, J. Wesson

“…Abstract The value of screening for cognitive impairment, including dementia and Alzheimer's disease, has been debated for decades. Recent research on causes…”
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Artificial Intelligence–Powered Digital Health Platform and Wearable Devices Improve Outcomes for Older Adults in Assisted Living Communities: Pilot Intervention Study by Wilmink, Gerald, Dupey, Katherine, Alkire, Schon, Grote, Jeffrey, Zobel, Gregory, Fillit, Howard M, Movva, Satish

“…Background Wearables and artificial intelligence (AI)–powered digital health platforms that utilize machine learning algorithms can autonomously measure a…”
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End‐of‐life burdensome interventions among Medicare fee‐for‐service beneficiaries with no dementia, non‐advanced dementia, and advanced dementia by Zhu, Yingying, Olchanski, Natalia, Freund, Karen M, Faul, Jessica D, Fillit, Howard M, Breslau, Rachel M, Cohen, Joshua T, Neumann, Peter J, Lin, Pei‐Jung

“…Background Older adults with dementia have difficulties communicating their treatment preferences and experience end‐of‐life burdensome interventions with…”
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