Search Results - "FILLINGER, Janos"

Current therapy of KRAS-mutant lung cancer by Ghimessy, Aron, Radeczky, Peter, Laszlo, Viktoria, Hegedus, Balazs, Renyi-Vamos, Ferenc, Fillinger, Janos, Klepetko, Walter, Lang, Christian, Dome, Balazs, Megyesfalvi, Zsolt

“…KRAS mutations are the most frequent gain-of-function alterations in patients with lung adenocarcinoma (LADC) in the Western world. Although they have been…”
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Proteomic Workflows for High-Quality Quantitative Proteome and Post-Translational Modification Analysis of Clinically Relevant Samples from Formalin-Fixed Paraffin-Embedded Archives by Kuras, Magdalena, Woldmar, Nicole, Kim, Yonghyo, Hefner, Max, Malm, Johan, Moldvay, Judit, Döme, Balázs, Fillinger, János, Pizzatti, Luciana, Gil, Jeovanis, Marko-Varga, György, Rezeli, Melinda

“…Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that…”
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Inter- and intratumoral proteomics and glycosaminoglycan characterization of ALK rearranged lung adenocarcinoma tissues: a pilot study by Balbisi, Mirjam, Sugár, Simon, Schlosser, Gitta, Szeitz, Beáta, Fillinger, János, Moldvay, Judit, Drahos, László, Szász, A. Marcell, Tóth, Gábor, Turiák, Lilla

“…Lung cancer is one of the most common types of cancer with limited therapeutic options, therefore a detailed understanding of the underlying molecular changes…”
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A clonal expression biomarker associates with lung cancer mortality by Biswas, Dhruva, Birkbak, Nicolai J., Rosenthal, Rachel, Hiley, Crispin T., Lim, Emilia L., Papp, Krisztian, Boeing, Stefan, Krzystanek, Marcin, Djureinovic, Dijana, La Fleur, Linnea, Greco, Maria, Döme, Balázs, Fillinger, János, Brunnström, Hans, Wu, Yin, Moore, David A., Skrzypski, Marcin, Abbosh, Christopher, Litchfield, Kevin, Al Bakir, Maise, Watkins, Thomas B. K., Veeriah, Selvaraju, Wilson, Gareth A., Jamal-Hanjani, Mariam, Moldvay, Judit, Botling, Johan, Chinnaiyan, Arul M., Micke, Patrick, Hackshaw, Allan, Bartek, Jiri, Csabai, Istvan, Szallasi, Zoltan, Herrero, Javier, McGranahan, Nicholas, Swanton, Charles

“…An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical…”
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Spatially Resolved Proteomic and Transcriptomic Profiling of Anaplastic Lymphoma Kinase-Rearranged Pulmonary Adenocarcinomas Reveals Key Players in Inter- and Intratumoral Heterogeneity by Szeitz, Beáta, Glasz, Tibor, Herold, Zoltán, Tóth, Gábor, Balbisi, Mirjam, Fillinger, János, Horváth, Szabolcs, Mohácsi, Réka, Kwon, Ho Jeong, Moldvay, Judit, Turiák, Lilla, Szász, Attila Marcell

“…Pulmonary adenocarcinomas (pADCs) with an rearrangement are a rare cancer subtype, necessitating comprehensive molecular investigations to unravel their…”
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Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients by Rojkó, Lívia, Reiniger, Lilla, Téglási, Vanda, Fábián, Katalin, Pipek, Orsolya, Vágvölgyi, Attila, Agócs, László, Fillinger, János, Kajdácsi, Zita, Tímár, József, Döme, Balázs, Szállási, Zoltán, Moldvay, Judit

“…Objectives While the predictive value of programmed cell death ligand-1 (PD-L1) protein expression for immune checkpoint inhibitor therapy of lung cancer has…”
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Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary disease and NSCLC by Gémes, Nikolett, Balog, József Á, Neuperger, Patrícia, Schlegl, Erzsébet, Barta, Imre, Fillinger, János, Antus, Balázs, Zvara, Ágnes, Hegedűs, Zoltán, Czimmerer, Zsolt, Manczinger, Máté, Balogh, Gergő Mihály, Tóvári, József, Puskás, László G, Szebeni, Gábor J

“…Tobacco smoking generates airway inflammation in chronic obstructive pulmonary disease (COPD), and its involvement in the development of lung cancer is still…”
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Comparative expression analysis of immune-related markers in surgically resected lung neuroendocrine neoplasms by Ferencz, Bence, Megyesfalvi, Zsolt, Csende, Kristóf, Fillinger, János, Poór, Valentin, Lantos, András, Pipek, Orsolya, Sólyom-Tisza, Anna, Rényi-Vámos, Ferenc, Schelch, Karin, Lang, Christian, Schwendenwein, Anna, Boettiger, Kristiina, László, Viktória, Hoetzenecker, Konrad, Döme, Balázs, Berta, Judit

“…•Atypical carcinoids are characterized by high tumor cell CD40 expression.•High CD70 and CD137 expression by tumor cells are characteristic for LCNEC.•SCLC has…”
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Expression patterns of novel immunotherapy targets in intermediate- and high-grade lung neuroendocrine neoplasms by Ferencz, Bence, Török, Klára, Pipek, Orsolya, Fillinger, János, Csende, Kristóf, Lantos, András, Černeková, Radoslava, Mitták, Marcel, Škarda, Jozef, Delongová, Patricie, Megyesfalvi, Evelyn, Schelch, Karin, Lang, Christian, Solta, Anna, Boettiger, Kristiina, Brcic, Luka, Lindenmann, Jörg, Rényi-Vámos, Ferenc, Aigner, Clemens, Berta, Judit, Megyesfalvi, Zsolt, Döme, Balázs

“…Background Advancements in immunotherapeutic approaches only had a modest impact on the therapy of lung neuroendocrine neoplasms (LNENs). Our multicenter study…”
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Molecular profiles of small cell lung cancer subtypes: Therapeutic implications by Schwendenwein, Anna, Megyesfalvi, Zsolt, Barany, Nandor, Valko, Zsuzsanna, Bugyik, Edina, Lang, Christian, Ferencz, Bence, Paku, Sandor, Lantos, Andras, Fillinger, Janos, Rezeli, Melinda, Marko-Varga, Gyorgy, Bogos, Krisztina, Galffy, Gabriella, Renyi-Vamos, Ferenc, Hoda, Mir Alireza, Klepetko, Walter, Hoetzenecker, Konrad, Laszlo, Viktoria, Dome, Balazs

“…Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers) is an exceptionally lethal malignancy characterized by rapid doubling…”
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Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma by Gyulai, Marton, Harko, Tunde, Fabian, Katalin, Karsko, Luca, Agocs, Laszlo, Szigeti, Balazs, Fillinger, Janos, Szallasi, Zoltan, Pipek, Orsolya, Moldvay, Judit

“…Background: Although the expression of tight junction protein claudins (CLDNs) is well known in common histological subtypes of lung cancer, it has not been…”
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Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma by Bilecz, Agnes, Stockhammer, Paul, Theegarten, Dirk, Kern, Izidor, Jakopovic, Marko, Samarzija, Miroslav, Klikovits, Thomas, Hoda, Mir A, Döme, Balázs, Oberndorfer, Felicitas, Muellauer, Leonhard, Fillinger, János, Kovács, Ildikó, Pirker, Christine, Schuler, Martin, Plönes, Till, Aigner, Clemens, Klepetko, Walter, Berger, Walter, Brcic, Luka, Laszlo, Viktória, Hegedus, Balazs

“…Aims Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable…”
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Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited by Abdelwahab, ElHusseiny M. M., Bovari-Biri, Judit, Smuk, Gabor, Fillinger, Janos, McPhail, Donald, Krymskaya, Vera P., Pongracz, Judit E.

“…Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC…”
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A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures by Diossy, Miklos, Sztupinszki, Zsofia, Borcsok, Judit, Krzystanek, Marcin, Tisza, Viktoria, Spisak, Sandor, Rusz, Orsolya, Timar, Jozsef, Csabai, István, Fillinger, Janos, Moldvay, Judit, Pedersen, Anders Gorm, Szuts, David, Szallasi, Zoltan

“…PARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2…”
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PD-1 and PD-L1 expression in rare lung tumors by Gyulai, Marton, Megyesfalvi, Zsolt, Reiniger, Lilla, Harko, Tunde, Ferencz, Bence, Karsko, Luca, Agocs, Laszlo, Fillinger, Janos, Dome, Balazs, Szallasi, Zoltan, Moldvay, Judit

“…Our knowledge is still limited about the characteristics and treatment of rare lung tumors. The aim of our study was to determine programmed cell death…”
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C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer by Lang, Christian, Megyesfalvi, Zsolt, Lantos, Andras, Oberndorfer, Felicitas, Hoda, Mir Alireza, Solta, Anna, Ferencz, Bence, Fillinger, Janos, Solyom-Tisza, Anna, Querner, Alessandro Saeed, Egger, Felix, Boettiger, Kristiina, Klikovits, Thomas, Timelthaler, Gerald, Renyi-Vamos, Ferenc, Aigner, Clemens, Hoetzenecker, Konrad, Laszlo, Viktoria, Schelch, Karin, Dome, Balazs

“…By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might…”
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The landscape of small cell lung cancer metastases: Organ specificity and timing by Megyesfalvi, Zsolt, Tallosy, Bernadett, Pipek, Orsolya, Fillinger, Janos, Lang, Christian, Klikovits, Thomas, Schwendenwein, Anna, Hoda, Mir Alireza, Renyi‐Vamos, Ferenc, Laszlo, Viktoria, Rezeli, Melinda, Moldvay, Judit, Dome, Balazs

“…Background Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear…”
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Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations by Abdelwahab, Elhusseiny Mohamed Mahmoud, Bovari-Biri, Judit, Smuk, Gabor, Harko, Tunde, Fillinger, Janos, Moldvay, Judit, Krymskaya, Vera P, Pongracz, Judit E

“…Mutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular…”
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Lymphangiogenesis Correlates with Lymph Node Metastasis, Prognosis, and Angiogenic Phenotype in Human Non–Small Cell Lung Cancer by RENYI-VAMOS, Ferenc, TOVARI, Jozsef, FILLINGER, Janos, TIMAR, Jozsef, PAKU, Sandor, KENESSEY, Istvan, OSTOROS, Gyula, AGOCS, Laszlo, SOLTESZ, Ibolya, DOME, Balazs

“…Purpose: Recent experimental studies have revealed that lymphangiogenesis plays an important role in cancer progression, but its clinical significance in the…”
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Comparison of Predictive Immunohistochemical Marker Expression of Primary Breast Cancer and Paired Distant Metastasis using Surgical Material: A Practice-Based Study by Kulka, Janina, Székely, Borbála, Lukács, Lilla V., Kiss, Orsolya, Tőkés, Anna-Mária, Vincze, Eszter, Turányi, Eszter, Fillinger, János, Hanzély, Zoltán, Arató, Gabriella, Szendrői, Miklós, Győrffy, Balázs, Szász, A. Marcell

“…Parallel studies of primary breast carcinomas and corresponding distant metastases samples reveal considerable differences. Our aim was to highlight this issue…”
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