Search Results - "FIDLER, Jonathan A"

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats by Mansouri, Mohammed Taghi, Fidler, Jonathan A., Meng, Qing Cheng, Eckenhoff, Roderic G., García, Paul S.

“…Clinical studies have demonstrated sex-related differences in recovery from surgical anesthesia. This study aimed to characterize the emergence pattern…”
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Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis by Dodge, James C., Treleaven, Christopher M., Fidler, Jonathan A., Tamsett, Thomas J., Bao, Channa, Searles, Michelle, Taksir, Tatyana V., Misra, Kuma, Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.

“…Metabolic dysfunction is an important modulator of disease course in amyotrophic lateral sclerosis (ALS). We report here that a familial mouse model…”
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AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice by Dodge, James C, Treleaven, Christopher M, Fidler, Jonathan A, Hester, Mark, Haidet, Amanda, Handy, Chalonda, Rao, Meghan, Eagle, Amy, Matthews, Jennifer C, Taksir, Tatyana V, Cheng, Seng H, Shihabuddin, Lamya S, Kaspar, Brian K

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron cell death in the cortex, brainstem, and spinal cord…”
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Combination Brain and Systemic Injections of AAV Provide Maximal Functional and Survival Benefits in the Niemann-Pick Mouse by Passini, Marco A., Bu, Jie, Fidler, Jonathan A., Ziegler, Robin J., Foley, Joseph W., Dodge, James C., Yang, Wendy W., Clarke, Jennifer, Taksir, Tatyana V., Griffiths, Denise A., Zhao, Michael A., O'Riordan, Catherine R., Schuchman, Edward H., Shihabuddin, Lamya S., Cheng, Seng H.

“…Niemann-Pick disease (NPD) is caused by the loss of acid sphingomyelinase (ASM) activity, which results in widespread accumulation of undegraded lipids in…”
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Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery by Treleaven, Christopher M, Tamsett, Thomas, Fidler, Jonathan A, Taksir, Tatyana V, Cheng, Seng H, Shihabuddin, Lamya S, Dodge, James C

“…Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we reported that…”
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Effects of γ-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia by Safavynia, Seyed A, Keating, Glenda, Speigel, Iris, Fidler, Jonathan A, Kreuzer, Matthias, Rye, David B, Jenkins, Andrew, García, Paul S

“…BACKGROUND:Transitions into conscious states are partially mediated by inactivation of sleep networks and activation of arousal networks. Pharmacologic…”
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Concentration-Dependent Dual Role of Thrombin in Protection of Cultured Rat Cortical Neurons by García, Paul S., Ciavatta, Vincent T., Fidler, Jonathan A., Woodbury, Anna, Levy, Jerrold H., Tyor, William R.

“…Thrombin’s role in the nervous system is not well understood. Under conditions of blood–brain barrier compromise (e.g., neurosurgery or stroke), thrombin can…”
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Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann–Pick A disease by Dodge, James C., Clarke, Jennifer, Treleaven, Christopher M., Taksir, Tatyana V., Griffiths, Denise A., Yang, Wendy, Fidler, Jonathan A., Passini, Marco A., Karey, Kenneth P., Schuchman, Edward H., Cheng, Seng H., Shihabuddin, Lamya S.

“…Niemann–Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we showed that…”
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Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse by Yang, Wendy W, Sidman, Richard L, Taksir, Tatyana V, Treleaven, Christopher M, Fidler, Jonathan A, Cheng, Seng H, Dodge, James C, Shihabuddin, Lamya S

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. However,…”
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Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone by Fidler, Jonathan A., Treleaven, Christopher M., Frakes, Ashley, Tamsett, Thomas J., McCrate, Mary, Cheng, Seng H., Shihabuddin, Lamya S., Kaspar, Brian K., Dodge, James C.

“…ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron cell loss, muscular atrophy, and a…”
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Gene Transfer to the CNS Is Efficacious in Immune-primed Mice Harboring Physiologically Relevant Titers of Anti-AAV Antibodies by Treleaven, Christopher M, Tamsett, Thomas J, Bu, Jie, Fidler, Jonathan A, Sardi, S Pablo, Hurlbut, Gregory D, Woodworth, Lisa A, Cheng, Seng H, Passini, Marco A, Shihabuddin, Lamya S, Dodge, James C

“…Central nervous system (CNS)-directed gene therapy with recombinant adeno-associated virus (AAV) vectors has been used effectively to slow disease course in…”
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Relationship between neuropathology and disease progression in the SOD1G93A ALS mouse by YANG, Wendy W, SIDMAN, Richard L, TAKSIR, Tatyana V, TRELEAVEN, Christopher M, FIDLER, Jonathan A, CHENG, Seng H, DODGE, James C, SHIHABUDDIN, Lamya S

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893. Second Generation Gene Therapy Vector for Classical Late Infantile Neuronal Ceroid Lipofuscinosis by Cabrera-Salazar, Mario A., Hodges, Bradley L., Yew, Nelson S., Bu, Jie, Fidler, Jonathan A., Roskelley, Eric M., Scheule, Ronald K., Sleat, David E., Lobel, Peter, Cheng, Seng H., Passini, Marco A.

“…Classical late infantile neuronal ceroid lipofuscinosis (cLINCL) is a neurodegenerative disorder that results from the loss of tripeptidyl peptidase I (TPP1)…”
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In Reply to MS # ALN-D-16-00854 and MS # ALN-D-16-00904 by Safavynia, Seyed A., Keating, Glenda, Speigel, Iris, Fidler, Jonathan A., Kreuzer, Matthias, Rye, David B., Jenkins, Andrew, García, Paul S.

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In Reply by Safavynia, Seyed A., Keating, Glenda, Speigel, Iris, Fidler, Jonathan A., Kreuzer, Matthias, Rye, David B., Jenkins, Andrew, García, Paul S.

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The effects of GABAA receptor modulation by flumazenil on emergence from general anesthesia by Safavynia, Seyed A., Keating, Glenda, Spiegel, Iris, Fidler, Jonathan A., Kreuzer, Matthias, Rye, David B., Jenkins, Andrew, García, Paul S.

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In Reply by Safavynia, Seyed A, Keating, Glenda, Speigel, Iris, Fidler, Jonathan A, Kreuzer, Matthias, Rye, David B, Jenkins, Andrew, García, Paul S

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In Reply by Safavynia, Seyed A, Keating, Glenda, Speigel, Iris, Fidler, Jonathan A, Kreuzer, Matthias, Rye, David B, Jenkins, Andrew, García, Paul S

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Relationship between neuropathology and disease progression in the SOD1 super(G93A) ALS mouse by Yang, Wendy W, Sidman, Richard L, Taksir, Tatyana V, Treleaven, Christopher M, Fidler, Jonathan A, Cheng, Seng H, Dodge, James C, Shihabuddin, Lamya S

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. However,…”
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Relationship between neuropathology and disease progression in the SOD1 G93A ALS mouse by Yang, Wendy W., Sidman, Richard L., Taksir, Tatyana V., Treleaven, Christopher M., Fidler, Jonathan A., Cheng, Seng H., Dodge, James C., Shihabuddin, Lamya S.

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. However,…”
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